Clinical and Laboratory Features of Three Rare Chinese V210I gCJD Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethics Statement
2.2. Data Collection
2.3. Routine Laboratory Tests for CJD
2.4. RT-QuIC Assays
3. Results
3.1. Clinical Data
3.2. Laboratory Tests
3.3. Family History
3.4. PRNP Sequencing
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Gender, on Set Age | Dementia 1 | Other Major CJD-Associated Problems 2 | EEG | CSF | MRI | Polymorphism | Duration | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
I | II | III | VI | PSWCs | 14-3-3 | RT-QuIC | Ribbon-like signal | High signals in caudate/putamen | Codon 129 | Codon 219 | Interval from onset to mutism | Situation | |||
Case 1 | M, 69 y | + | + | + | + | + | untypical | + | - | + | + | M/M | E/E | app. 30 days | Died 75 days after onset |
Case 2 | M, 64 y | + | + | + | + | + | typical | + | + | + | - | M/M | E/E | app. 50 days | Alive with mutism |
Case 3 | M, 59 y | + | - | + | + | + | typical | + | - | + | + | M/M | E/E | app. 40 days | Died 9 months after onset |
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Xiao, K.; Zhou, W.; Gao, L.-P.; Wu, Y.-Z.; Wang, Y.; Chen, C.; Gao, C.; Shi, Q.; Dong, X.-P. Clinical and Laboratory Features of Three Rare Chinese V210I gCJD Patients. Pathogens 2020, 9, 800. https://doi.org/10.3390/pathogens9100800
Xiao K, Zhou W, Gao L-P, Wu Y-Z, Wang Y, Chen C, Gao C, Shi Q, Dong X-P. Clinical and Laboratory Features of Three Rare Chinese V210I gCJD Patients. Pathogens. 2020; 9(10):800. https://doi.org/10.3390/pathogens9100800
Chicago/Turabian StyleXiao, Kang, Wei Zhou, Li-Ping Gao, Yue-Zhang Wu, Yuan Wang, Cao Chen, Chen Gao, Qi Shi, and Xiao-Ping Dong. 2020. "Clinical and Laboratory Features of Three Rare Chinese V210I gCJD Patients" Pathogens 9, no. 10: 800. https://doi.org/10.3390/pathogens9100800