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Microorganisms
Volume 11
Issue 2
10.3390/microorganisms11020470
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Review

Local and Systemic Effects of Porphyromonas gingivalis Infection

by
William A. Chen
1,
Yuetan Dou
2,
Hansel M. Fletcher
2 and
Danilo S. Boskovic
1,*
1
Division of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
2
Division of Microbiology and Molecular Genetics, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
*
Author to whom correspondence should be addressed.
Microorganisms 2023, 11(2), 470; https://doi.org/10.3390/microorganisms11020470
Submission received: 28 December 2022 / Revised: 31 January 2023 / Accepted: 2 February 2023 / Published: 13 February 2023
(This article belongs to the Special Issue Customized Minimally Invasive Protocols for the Clinical and Microbiological Management of the Oral Microbiota)
Versions Notes

Abstract

Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and oral microbiota. It is advantageous for P. gingivalis to avoid complete host immunosuppression, as inflammation-induced tissue damage provides essential nutrients necessary for robust bacterial proliferation. In this context, P. gingivalis can gain access to the systemic circulation, where it can promote a prothrombotic state. P. gingivalis expresses a number of virulence factors, which aid this pathogen toward infection of a variety of host cells, evasion of detection by the host immune system, subversion of the host immune responses, and activation of several humoral and cellular hemostatic factors.
Keywords: dentistry; inflammation; neutrophils; periodontitis; periodontology; platelets; Porphyromonas gingivalis dentistry; inflammation; neutrophils; periodontitis; periodontology; platelets; Porphyromonas gingivalis

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MDPI and ACS Style

Chen, W.A.; Dou, Y.; Fletcher, H.M.; Boskovic, D.S. Local and Systemic Effects of Porphyromonas gingivalis Infection. Microorganisms 2023, 11, 470. https://doi.org/10.3390/microorganisms11020470

AMA Style

Chen WA, Dou Y, Fletcher HM, Boskovic DS. Local and Systemic Effects of Porphyromonas gingivalis Infection. Microorganisms. 2023; 11(2):470. https://doi.org/10.3390/microorganisms11020470

Chicago/Turabian Style

Chen, William A., Yuetan Dou, Hansel M. Fletcher, and Danilo S. Boskovic. 2023. "Local and Systemic Effects of Porphyromonas gingivalis Infection" Microorganisms 11, no. 2: 470. https://doi.org/10.3390/microorganisms11020470

APA Style

Chen, W. A., Dou, Y., Fletcher, H. M., & Boskovic, D. S. (2023). Local and Systemic Effects of Porphyromonas gingivalis Infection. Microorganisms, 11(2), 470. https://doi.org/10.3390/microorganisms11020470

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