Next Article in Journal
Lumpy Skin Disease Virus Infection Activates Autophagy and Endoplasmic Reticulum Stress-Related Cell Apoptosis in Primary Bovine Embryonic Fibroblast Cells
Next Article in Special Issue
Personalized Response of Parkinson’s Disease Gut Microbiota to Nootropic Medicinal Herbs In Vitro: A Proof of Concept
Previous Article in Journal
Whole-Genome Sequencing of Mycobacterium tuberculosis Isolates from Diabetic and Non-Diabetic Patients with Pulmonary Tuberculosis
Previous Article in Special Issue
The Potential Value of Probiotics after Dental Implant Placement
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Microorganisms
Volume 11
Issue 8
10.3390/microorganisms11081882
microorganisms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Effect of Oral Administration of Polyethylene Glycol 400 on Gut Microbiota Composition and Diet-Induced Obesity in Mice

by
Riko Ishibashi
1,
Rio Matsuhisa
1,
Mio Nomoto
1,
Seita Chudan
2,
Miyu Nishikawa
2,
Yoshiaki Tabuchi
3,
Shinichi Ikushiro
2,
Yoshinori Nagai
1 and
Yukihiro Furusawa
1,*
1
Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Toyama 939-0398, Japan
2
Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Kurokawa, Toyama 939-0398, Japan
3
Division of Molecular Genetics Research, Life Science Research Center, University of Toyama, Sugitani, Toyama 930-0194, Japan
*
Author to whom correspondence should be addressed.
Microorganisms 2023, 11(8), 1882; https://doi.org/10.3390/microorganisms11081882
Submission received: 23 June 2023 / Revised: 20 July 2023 / Accepted: 24 July 2023 / Published: 26 July 2023
(This article belongs to the Special Issue Gut Microbiota: Health, Clinical & Beyonds)
Browse Figures
Review Reports Versions Notes

Abstract

Polyethylene glycol (PEG) is a commonly used dispersant for oral administration of hydrophobic agents. PEG is partly absorbed in the small intestine, and the unabsorbed fraction reaches the large intestine; thus, oral administration of PEG may impact the gut microbial community. However, to the best of our knowledge, no study evaluated the effects of PEG on gut commensal bacteria. Herein, we aimed to determine whether oral administration of PEG modifies the gut microbiota. Administration of PEG400 and PEG4000 altered gut microbial diversity in a concentration-dependent manner. Taxonomic analysis revealed that Akkermansia muciniphila and particularly Parabacteroides goldsteinii were overrepresented in mice administered with 40% PEG. PEG400 administration ameliorated the high-fat diet (HFD)-induced obesity and adipose tissue inflammation. Fecal microbiome transplantation from PEG400-administered donors counteracted the HFD-induced body and epididymal adipose tissue weight gain, indicating that PEG400-associated bacteria are responsible for the anti-obesity effect. Conversely, carboxymethyl cellulose, also used as a dispersant, did not affect the abundance of these two bacterial species or HFD-induced obesity. In conclusion, we demonstrated that oral administration of a high concentration of PEG400 (40%) alters the gut microbiota composition and ameliorates HFD-induced obesity.
Keywords: polyethylene glycol (PEG); carboxymethyl cellulose (CMC); gut microbiota; obesity; Parabacteroides goldsteinii; Akkermansia muciniphila polyethylene glycol (PEG); carboxymethyl cellulose (CMC); gut microbiota; obesity; Parabacteroides goldsteinii; Akkermansia muciniphila

Share and Cite

MDPI and ACS Style

Ishibashi, R.; Matsuhisa, R.; Nomoto, M.; Chudan, S.; Nishikawa, M.; Tabuchi, Y.; Ikushiro, S.; Nagai, Y.; Furusawa, Y. Effect of Oral Administration of Polyethylene Glycol 400 on Gut Microbiota Composition and Diet-Induced Obesity in Mice. Microorganisms 2023, 11, 1882. https://doi.org/10.3390/microorganisms11081882

AMA Style

Ishibashi R, Matsuhisa R, Nomoto M, Chudan S, Nishikawa M, Tabuchi Y, Ikushiro S, Nagai Y, Furusawa Y. Effect of Oral Administration of Polyethylene Glycol 400 on Gut Microbiota Composition and Diet-Induced Obesity in Mice. Microorganisms. 2023; 11(8):1882. https://doi.org/10.3390/microorganisms11081882

Chicago/Turabian Style

Ishibashi, Riko, Rio Matsuhisa, Mio Nomoto, Seita Chudan, Miyu Nishikawa, Yoshiaki Tabuchi, Shinichi Ikushiro, Yoshinori Nagai, and Yukihiro Furusawa. 2023. "Effect of Oral Administration of Polyethylene Glycol 400 on Gut Microbiota Composition and Diet-Induced Obesity in Mice" Microorganisms 11, no. 8: 1882. https://doi.org/10.3390/microorganisms11081882

APA Style

Ishibashi, R., Matsuhisa, R., Nomoto, M., Chudan, S., Nishikawa, M., Tabuchi, Y., Ikushiro, S., Nagai, Y., & Furusawa, Y. (2023). Effect of Oral Administration of Polyethylene Glycol 400 on Gut Microbiota Composition and Diet-Induced Obesity in Mice. Microorganisms, 11(8), 1882. https://doi.org/10.3390/microorganisms11081882

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop