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Microorganisms
Volume 12
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10.3390/microorganisms12061037
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Article

Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children

by
Maria Daniel
1,
Hanna Szymanik-Grzelak
1,*,
Janusz Sierdziński
2 and
Małgorzata Pańczyk-Tomaszewska
1
1
Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland
2
Department of Medical Informatics and Telemedicine, Medical University of Warsaw, 02-091 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Microorganisms 2024, 12(6), 1037; https://doi.org/10.3390/microorganisms12061037
Submission received: 10 April 2024 / Revised: 3 May 2024 / Accepted: 17 May 2024 / Published: 21 May 2024
(This article belongs to the Special Issue Effects of Probiotics on Health, 2nd Edition)
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Abstract

Urinary tract infections (UTIs) rank among the most prevalent bacterial infections in children. Probiotics appear to reduce the risk of recurrence of UTIs. This study aimed to evaluate whether probiotics containing Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 therapy prevent UTIs in the pediatric population compared to a placebo. A superiority, double-blind, randomized, controlled trial was conducted. In total, 54 children aged 3–18 years with recurrent UTIs or ≥one acute pyelonephritis and ≥one risk factor of recurrence of UTIs were randomly assigned (27 patients in each arm) to a 90-day probiotic or placebo arm. The age, sex, diagnosis, renal function, risk factors, and etiology of UTIs did not vary between the groups. During the intervention, 26% of children taking the probiotic had episodes of UTI, and it was not significantly less than in the placebo group. The number of UTI episodes during the intervention and the follow-up period decreased significantly in both groups, but the difference between them was insignificant. We observed a decrease in UTIs during the study of almost 50% in the probiotic group compared to the placebo group. Probiotics can be used as natural, safe prophylaxis for children with risk factors for UTIs in whom antibiotic prevention is not indicated.
Keywords: probiotics; prophylaxis; urinary tract infection; Lactobacillus probiotics; prophylaxis; urinary tract infection; Lactobacillus

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MDPI and ACS Style

Daniel, M.; Szymanik-Grzelak, H.; Sierdziński, J.; Pańczyk-Tomaszewska, M. Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children. Microorganisms 2024, 12, 1037. https://doi.org/10.3390/microorganisms12061037

AMA Style

Daniel M, Szymanik-Grzelak H, Sierdziński J, Pańczyk-Tomaszewska M. Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children. Microorganisms. 2024; 12(6):1037. https://doi.org/10.3390/microorganisms12061037

Chicago/Turabian Style

Daniel, Maria, Hanna Szymanik-Grzelak, Janusz Sierdziński, and Małgorzata Pańczyk-Tomaszewska. 2024. "Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children" Microorganisms 12, no. 6: 1037. https://doi.org/10.3390/microorganisms12061037

APA Style

Daniel, M., Szymanik-Grzelak, H., Sierdziński, J., & Pańczyk-Tomaszewska, M. (2024). Lactobacillus rhamnosus PL1 and Lactobacillus plantarum PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children. Microorganisms, 12(6), 1037. https://doi.org/10.3390/microorganisms12061037

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