This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessArticle
Comparative Genomics of Limosilactobacillus reuteri YLR001 Reveals Genetic Diversity and Probiotic Properties
by
Lihong Zhang
Lihong Zhang 1,*
,
Md. F. Kulyar
Md. F. Kulyar 2
,
Tian Niu
Tian Niu 1,
Shuai Yang
Shuai Yang 1 and
Wenjing Chen
Wenjing Chen 1
1
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China
2
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
*
Author to whom correspondence should be addressed.
Microorganisms 2024, 12(8), 1636; https://doi.org/10.3390/microorganisms12081636 (registering DOI)
Submission received: 25 June 2024
/
Revised: 3 August 2024
/
Accepted: 7 August 2024
/
Published: 10 August 2024
Abstract
To gain deeper insights into the genomic characteristics of Limosilactobacillus reuteri (L. reuteri) YLR001 and uncover its probiotic properties, in the current study, a comprehensive analysis of its whole genome was conducted, explicitly exploring the genetic variations associated with different host organisms. The genome of YLR001 consisted of a circular 2,242,943 bp chromosome with a GC content of 38.84%, along with three circular plasmids (24,864, 38, 926, and 132,625 bp). Among the 2183 protein-coding sequences (CDSs), the specific genes associated with genetic adaptation and stress resistance were identified. We predicted the function of COG protein genes and analyzed the KEGG pathways. Comparative genome analysis revealed that the pan-genome contained 5207 gene families, including 475 core gene families and 941 strain-specific genes. Phylogenetic analysis revealed distinct host specificity among 20 strains of L. reuteri, highlighting substantial genetic diversity across different hosts. This study enhanced our comprehension of the genetic diversity of L. reuteri YLR001, demonstrated its potential probiotic characteristics, and established more solid groundwork for future applications.
Share and Cite
MDPI and ACS Style
Zhang, L.; Kulyar, M.F.; Niu, T.; Yang, S.; Chen, W.
Comparative Genomics of Limosilactobacillus reuteri YLR001 Reveals Genetic Diversity and Probiotic Properties. Microorganisms 2024, 12, 1636.
https://doi.org/10.3390/microorganisms12081636
AMA Style
Zhang L, Kulyar MF, Niu T, Yang S, Chen W.
Comparative Genomics of Limosilactobacillus reuteri YLR001 Reveals Genetic Diversity and Probiotic Properties. Microorganisms. 2024; 12(8):1636.
https://doi.org/10.3390/microorganisms12081636
Chicago/Turabian Style
Zhang, Lihong, Md. F. Kulyar, Tian Niu, Shuai Yang, and Wenjing Chen.
2024. "Comparative Genomics of Limosilactobacillus reuteri YLR001 Reveals Genetic Diversity and Probiotic Properties" Microorganisms 12, no. 8: 1636.
https://doi.org/10.3390/microorganisms12081636
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.