Actinomycetes from the Red Sea Sponge Coscinoderma mathewsi: Isolation, Diversity, and Potential for Bioactive Compounds Discovery
Abstract
:1. Introduction
2. Materials and Methods
2.1. Description of the Area for Sponge Collection
2.2. Chemicals and Reagents
2.3. Actinomycetes Isolation
2.4. Molecular Identification and Phylogenetic Analysis
2.5. Co-cultivation and Extract Preparation
2.6. Metabolic Profiling
2.7. Mycolic Acid Detection
2.8. Antibacterial Activity
2.9. Antifungal Activity
2.10. Anti-Trypanosomal Activity
2.11. Statistical Analysis
3. Results and Discussion
3.1. Molecular Identification and Phylogenetic Analysis
3.2. Metabolomic Profiling of Monoculture and Co-Culture Crude Extracts
3.2.1. Chemical Dereplication of Micromonospora sp. UA17
3.2.2. Chemical Dereplication of Gordonia sp. UA19
3.2.3. Chemical Dereplication of Nocardia sp. UA 23
3.2.4. Chemical Dereplication of Strains UA17 + UA19
3.2.5. Chemical Dereplication of Strains UA17 + UA23
3.2.6. Chemical Dereplication of Strain UA17 with Mycolic Acid
3.3. Antibacterial, Antifungal, and Anti-Trypanosomal Activities
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Isolate | Accession ID | Identity [%] | Source | Ref |
---|---|---|---|---|
Micromonospora terminaliae DSM 101760 | CP045309.1 | 96.678 | Surface sterilized stem of Thai medicinal plant Terminalia mucronata | [51] |
Micromonospora inositola DSM 43819 | LT607754.1 | 96.263 | forest soil | [52] |
Micromonospora cremea CR30 | NR_108478.1 | 96.258 | rhizosphere of Pisum sativum | [53] |
Micromonospora rosaria DSM 803 | NR_026282.1 | 96.125 | unknown | [54] |
Micromonospora palomenae NEAU-CX1 | NR_136848.1 | 96.055 | Nymphs of stinkbug (Palomena viridissima Poda) | [55] |
Isolate | Accession ID | Identity [%] | Source | Ref |
---|---|---|---|---|
Gordonia hongkongensis HKU50 | NR_152023.1 | 95.386 | human blood culture | [56] |
Gordonia terrae 3612 | CP016594.1 | 95.320 | soil | [57] |
Gordonia bronchialis DSM 43247 | NR_074529.1 | 94.470 | human sputum | [58] |
Gordonia desulfuricans 213E | NR_028734.1 | 94.412 | soil | [59] |
Gordonia rubripertincta DSM 43248 | NR_043330.1 | 94.345 | soil | [60] |
Isolate | Accession ID | Identity [%] | Source | Ref |
---|---|---|---|---|
Nocardia xestospongiae ST01-07 | NR_156866.1 | 96.972 | Xestospongia sp. | [61] |
Nocardia amikacinitolerans NBRC 108937 | NR_117564.1 | 96.972 | human eye (clinical isolate) | [62] |
Nocardia arthritidis DSM 44731 | NR_115824.1 | 96.898 | human sputum | [63] |
Nocardia araoensis NBRC 100135 | NR_118199.1 | 96.677 | human | [64] |
Nocardia beijingensis DSM 44636 | NR_118618.1 | 96.529 | mud from a sewage ditch | NA |
Sample Code | MIC (µg/mL) | MIC (µg/mL, 72 h.) Trypanosoma brucei TC 221 | ||
---|---|---|---|---|
Staphylococcus aureus NCTC 8325 | Enterococcus faecalis | Candida albicans 5314 | ||
Micromonospora sp. UA17 | 15.6 | 14.3 | 13.2 | >100 |
Gordonia sp. UA19 | 35.7 | 31.9 | 16.8 | >100 |
Nocardia sp. UA 23 | 38.9 | 39.2 | 25.7 | 7.2 * |
UA17 + UA19 | 8.6 * | 7.4 * | 6.4 * | >100 |
UA17 + UA23 | 4.2 * | 3.9 * | 3.8 * | >100 |
UA17 + Myc | 4.7 * | 3.8 * | 5.9 * | >100 |
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Shamikh, Y.I.; El Shamy, A.A.; Gaber, Y.; Abdelmohsen, U.R.; Madkour, H.A.; Horn, H.; Hassan, H.M.; Elmaidomy, A.H.; Alkhalifah, D.H.M.; Hozzein, W.N. Actinomycetes from the Red Sea Sponge Coscinoderma mathewsi: Isolation, Diversity, and Potential for Bioactive Compounds Discovery. Microorganisms 2020, 8, 783. https://doi.org/10.3390/microorganisms8050783
Shamikh YI, El Shamy AA, Gaber Y, Abdelmohsen UR, Madkour HA, Horn H, Hassan HM, Elmaidomy AH, Alkhalifah DHM, Hozzein WN. Actinomycetes from the Red Sea Sponge Coscinoderma mathewsi: Isolation, Diversity, and Potential for Bioactive Compounds Discovery. Microorganisms. 2020; 8(5):783. https://doi.org/10.3390/microorganisms8050783
Chicago/Turabian StyleShamikh, Yara I., Aliaa A. El Shamy, Yasser Gaber, Usama Ramadan Abdelmohsen, Hashem A. Madkour, Hannes Horn, Hossam M. Hassan, Abeer H. Elmaidomy, Dalal Hussien M. Alkhalifah, and Wael N. Hozzein. 2020. "Actinomycetes from the Red Sea Sponge Coscinoderma mathewsi: Isolation, Diversity, and Potential for Bioactive Compounds Discovery" Microorganisms 8, no. 5: 783. https://doi.org/10.3390/microorganisms8050783