Lactobacillus reuteri DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethics Statement
2.2. Investigational Products
2.3. Patient Recruitment and Sampling
2.4. Appraisal of the Cutaneous Acceptability by the Dermatologist Investigator and Cosmetic Acceptability
2.5. Clinical Evaluation by the Dermatologist Investigator
2.6. Determination of Number of Subject’s Sample Size
2.7. Statistical Analysis
2.8. Adverse Events
3. Results
3.1. Subject Characteristics
3.2. Cutaneous Acceptability of the Investigational Products
3.3. The Effect of the Products on SCORAD from Baseline to End of Study (Time Effect)
3.4. The Effect of the Products on Local SCORAD from Baseline to End of Study (Time Effect)
3.5. Adverse Events
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Appendix A
Frequency of the Reactions | Number of Subjects with Reactions | |
---|---|---|
Probiotic (n = 17) | Control (n = 17) | |
Reactions during the whole study | 7 | 5 |
Reactions observed by the dermatologist | 3 | 1 |
Reactions observed by the subject | ||
(per type of reaction) | ||
- Discomfort | 7 | 5 |
- Irritation | 3 | 2 |
- Edema | 0 | 0 |
- Dryness | 2 | 3 |
- Desquamation | 0 | 0 |
- “small pimples” | 0 | 2 |
Reactions that needed to modify the application modalities significantly | 0 | 0 |
Reactions which can be considered as relevant * | 0 | 0 |
Reactions considered as adverse events related to the investigational products | 0 | 0 |
Reactions considered as serious adverse events linked to the investigational products | 0 | 0 |
Cosmetic acceptability by the dermatologist investigator Very good—good | 17 | 17 |
Cosmetic acceptability by the subjects | ||
Very good-good | 11 | 9 |
Rather good -mediocre | 4 | 6 |
Bad | 2 | 1 |
Conclusion on Cutaneous Acceptability | GOOD | GOOD |
Means and Standard Deviations (SD) | ||||
---|---|---|---|---|
n | Probiotic | n | Control | |
Baseline (day 0) | 17 | 41.74 ± 14.66 | 16 | 36.69 ± 10.75 |
Visit 2 (day 28) | 17 | 30.20 ± 15.83 | 16 | 24.98 ± 11.06 |
Visit 3 (day 56) | 17 | 22.68 ± 15.38 | 16 | 23.96 ± 9.58 |
Means and Standard Deviations (SD) | ||||
---|---|---|---|---|
n | Probiotic | n | Control | |
Baseline (day 0) | 17 | 9.00 ± 3.95 | 16 | 8.19 ± 3.56 |
Visit 2 (day 28) | 17 | 6.76 ± 4.07 | 16 | 5.38 ± 2.92 |
Visit 3 (day 56) | 17 | 4.94 ± 4.25 | 16 | 4.94 ± 2.82 |
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Parameter | Probiotic Group (n = 17) | Control Group (n = 17) |
---|---|---|
Age in years (range) | 40.7 (19–66) | 33.1 (19–57) |
Female (n) | 17 | 15 |
Ethnicity (n) | ||
Caucasian | 7 | 6 |
Black | 10 | 11 |
Skin Appearance | ||
Normal | 2 | 2 |
Dry | 12 | 9 |
Very Dry | 3 | 6 |
AD severity at recruitment (SCORAD index) (x ± s.d) | 41.7 ± 14.7 | 36.7 ± 10.7 |
Subjects with other allergies | ||
Sinusitis | 2 | 2 |
Hay fever, pollen, dust, pets | 3 | 6 |
Average volume of product used during study duration (g) | 82.2 g | 62.9 g |
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Butler, É.; Lundqvist, C.; Axelsson, J. Lactobacillus reuteri DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis. Microorganisms 2020, 8, 1026. https://doi.org/10.3390/microorganisms8071026
Butler É, Lundqvist C, Axelsson J. Lactobacillus reuteri DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis. Microorganisms. 2020; 8(7):1026. https://doi.org/10.3390/microorganisms8071026
Chicago/Turabian StyleButler, Éile, Christoffer Lundqvist, and Jakob Axelsson. 2020. "Lactobacillus reuteri DSM 17938 as a Novel Topical Cosmetic Ingredient: A Proof of Concept Clinical Study in Adults with Atopic Dermatitis" Microorganisms 8, no. 7: 1026. https://doi.org/10.3390/microorganisms8071026