Sars-CoV-2 Virus Infection May Interfere CD34+ Hematopoietic Stem Cells and Megakaryocyte–Erythroid Progenitors Differentiation Contributing to Platelet Defection towards Insurgence of Thrombocytopenia and Thrombophilia
Abstract
:1. The CD-34+ Hematopoietic Stem Cells and the Risk of Thrombocytopenia and Thrombotic Events in COVID-19 Infection, the Hypotheses of the Disturbances in the Myeloid Trait
2. Validating the Premises
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Zhou, P.; Yang, X.-L.; Wang, X.-G.; Hu, B.; Zhang, L.; Zhang, W.; Si, H.-R.; Zhu, Y.; Li, B.; Huang, C.-L.; et al. A Pneumonia Outbreak Associated with a New Coronavirus of Probable Bat Origin. Nature 2020, 579, 270–273. [Google Scholar] [CrossRef] [Green Version]
- Wu, F.; Zhao, S.; Yu, B.; Chen, Y.-M.; Wang, W.; Song, Z.-G.; Hu, Y.; Tao, Z.-W.; Tian, J.-H.; Pei, Y.-Y.; et al. A New Coronavirus Associated with Human Respiratory Disease in China. Nature 2020, 579, 265–269. [Google Scholar] [CrossRef] [Green Version]
- Ratajczak, M.Z.; Kucia, M. SARS-CoV-2 Infection and Overactivation of Nlrp3 Inflammasome as a Trigger of Cytokine “Storm” and Risk Factor for Damage of Hematopoietic Stem Cells. Leukemia 2020, 34, 1726–1729. [Google Scholar] [CrossRef]
- Mantefardo, B.; Gube, A.A.; Awlachew, E.; Sisay, G. Novel Coronavirus (COVID-19)-Associated Guillain–Barre’ Syndrome: Case Report. IMCRJ 2021, 14, 251–253. [Google Scholar] [CrossRef]
- Caress, J.B.; Castoro, R.J.; Simmons, Z.; Scelsa, S.N.; Lewis, R.A.; Ahlawat, A.; Narayanaswami, P. COVID-19-Associated Guillain-Barré Syndrome: The Early Pandemic Experience. Muscle Nerve 2020, 62, 485–491. [Google Scholar] [CrossRef] [PubMed]
- Coronavirus Disease (COVID-19) Situation Reports. Available online: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports (accessed on 23 July 2021).
- Nur, E.; Gaartman, A.E.; Tuijn, C.F.J.; Tang, M.W.; Biemond, B.J. Vaso-occlusive Crisis and Acute Chest Syndrome in Sickle Cell Disease Due to 2019 Novel Coronavirus Disease (COVID-19). Am. J. Hematol. 2020, 95, 725–726. [Google Scholar] [CrossRef]
- Bieber, E. Erythropoietin, the Biology of Erythropoiesis and Epoetin Alfa. An Overview. J. Reprod. Med. 2001, 46, 521–530. [Google Scholar] [PubMed]
- Kaushansky, K. The Molecular Mechanisms That Control Thrombopoiesis. J. Clin. Investig. 2005, 115, 3339–3347. [Google Scholar] [CrossRef]
- Luck, L.; Zeng, L.; Hiti, A.L.; Weinberg, K.I.; Malik, P. Human CD34+ and CD34+CD38− Hematopoietic Progenitors in Sickle Cell Disease Differ Phenotypically and Functionally from Normal and Suggest Distinct Subpopulations That Generate F Cells. Exp. Hematol. 2004, 32, 483–493. [Google Scholar] [CrossRef] [PubMed]
- Kratz-Albers, K.; Scheding, S.; Möhle, R.; Bühring, H.J.; Baum, C.M.; Mc Kearn, J.P.; Büchner, T.; Kanz, L.; Brugger, W. Effective Ex Vivo Generation of Megakaryocytic Cells from Mobilized Peripheral Blood CD34+ Cells with Stem Cell Factor and Promegapoietin. Exp. Hematol. 2000, 28, 335–346. [Google Scholar] [CrossRef]
- Attar, A. Changes in the Cell Surface Markers during Normal Hematopoiesis: A Guide to Cell Isolation. Glob. J. Hematol. Blood Transfus. 2014, 1, 20–28. [Google Scholar] [CrossRef]
- Huerga Encabo, H.; Grey, W.; Garcia-Albornoz, M.; Wood, H.; Ulferts, R.; Aramburu, I.V.; Kulasekararaj, A.G.; Mufti, G.; Papayannopoulos, V.; Beale, R.; et al. Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients. Stem Cell Rep. 2021, 16, 428–436. [Google Scholar] [CrossRef] [PubMed]
- Odak, I.; Barros-Martins, J.; Bošnjak, B.; Stahl, K.; David, S.; Wiesner, O.; Busch, M.; Hoeper, M.M.; Pink, I.; Welte, T.; et al. Reappearance of Effector T Cells Is Associated with Recovery from COVID-19. EBioMedicine 2020, 57, 102885. [Google Scholar] [CrossRef]
- Shahbaz, S.; Xu, L.; Osman, M.; Sligl, W.; Shields, J.; Joyce, M.; Tyrrell, L.; Oyegbami, O.; Elahi, S. Erythroid Precursors and Progenitors Suppress Adaptive Immunity and Get Invaded by SARS-CoV-2. Stem Cell Rep. 2021, 16, 1165–1181. [Google Scholar] [CrossRef]
- Balzanelli, M.; Distratis, P.; Catucci, O.; Amatulli, F.; Cefalo, A.; Lazzaro, R.; Aityan, K.S.; Dalagni, G.; Nico, A.; De Michele, A.; et al. Clinical and Diagnostic Findings in COVID-19 Patients: An Original Research from SG Moscati Hospital in Taranto Italy. J. Biol. Regul. Homeost. Agents 2021, 35, 171–183. [Google Scholar] [CrossRef]
- Cavezzi, A.; Troiani, E.; Corrao, S. COVID-19: Hemoglobin, Iron, and Hypoxia beyond Inflammation. A Narrative Review. Clin. Pract. 2020, 10, 24–30. [Google Scholar] [CrossRef]
- Di Castelnuovo, A.; Costanzo, S.; Antinori, A.; Berselli, N.; Blandi, L.; Bonaccio, M.; Cauda, R.; Guaraldi, G.; Menicanti, L.; Mennuni, M.; et al. Heparin in COVID-19 Patients Is Associated with Reduced In-Hospital Mortality: The Multicenter Italian CORIST Study. Thromb. Haemost. 2021, 121, 1054–1065. [Google Scholar] [CrossRef]
- Zhang, S.; Liu, Y.; Wang, X.; Yang, L.; Li, H.; Wang, Y.; Liu, M.; Zhao, X.; Xie, Y.; Yang, Y.; et al. SARS-CoV-2 Binds Platelet ACE2 to Enhance Thrombosis in COVID-19. J. Hematol. Oncol. 2020, 13, 120. [Google Scholar] [CrossRef]
- Roth, H.; Schneider, L.; Eberle, R.; Lausen, J.; Modlich, U.; Blümel, J.; Baylis, S.A. Zika Virus Infection Studies with CD34+ Hematopoietic and Megakaryocyte-Erythroid Progenitors, Red Blood Cells and Platelets. Transfusion 2020, 60, 561–574. [Google Scholar] [CrossRef] [Green Version]
- Balzanelli, G.M.; Distratis, P.; Amatulli, F.; Lazzaro, R.; Cefalo, A.; Dangela, G.; Catucci, O.; Palazzo, D.; Tomassone, D.; Pham, S.A.; et al. Would The End Of COVID-19 Infection As A Chronic Disease? J. Stem Cells Res. Dev. Ther. 2020, 6, 1–3. [Google Scholar] [CrossRef]
- Balzanelli, M.G.; Distratis, P.; Aityan, S.K.; Amatulli, F.; Catucci, O.; Cefalo, A.; De Michele, A.; Dipalma, G.; Inchingolo, F.; Lazzaro, R.; et al. An Alternative “Trojan Horse” Hypothesis for COVID-19: Immune Deficiency of IL-10 and SARS-CoV-2 Biology. Endocr. Metab. Immune Disord. Drug Targets 2021, 21, 1. [Google Scholar] [CrossRef]
- Balzanelli, G.M.; Distratis, P.; Amatulli, F.; Catucci, O.; Cefalo, A.; Lazzaro, R.; Palazzo, D.; Aityan, K.S.; Dipalma, G.; Inchingolo, F. Clinical Features in Predicting COVID-19. Biomed. J. Sci. Tech. Res. 2020, 29, 22921–22926. [Google Scholar]
- Greco, E.; Lupia, E.; Bosco, O.; Vizio, B.; Montrucchio, G. Platelets and Multi-Organ Failure in Sepsis. Int. J. Mol. Sci. 2017, 18, 2200. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Vardon-Bounes, F.; Ruiz, S.; Gratacap, M.-P.; Garcia, C.; Payrastre, B.; Minville, V. Platelets Are Critical Key Players in Sepsis. Int. J. Mol. Sci. 2019, 20, 3494. [Google Scholar] [CrossRef] [Green Version]
- Ballini, A.; Dipalma, G.; Isacco, C.G.; Boccellino, M.; Di Domenico, M.; Santacroce, L.; Nguyễn, K.C.D.; Scacco, S.; Calvani, M.; Boddi, A.; et al. Oral Microbiota and Immune System Crosstalk: A Translational Research. Biology 2020, 9, 131. [Google Scholar] [CrossRef] [PubMed]
- Cazzolla, A.P.; Lovero, R.; Lo Muzio, L.; Testa, N.F.; Schirinzi, A.; Palmieri, G.; Pozzessere, P.; Procacci, V.; Di Comite, M.; Ciavarella, D. Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6. ACS Chem. Neurosci. 2020, 11, 2774–2781. [Google Scholar] [CrossRef]
- Fernández-de-Las-Peñas, C.; Palacios-Ceña, D.; Gómez-Mayordomo, V.; Cuadrado, M.L.; Florencio, L.L. Defining Post-COVID Symptoms (Post-Acute COVID, Long COVID, Persistent Post-COVID): An Integrative Classification. Int. J. Environ. Res. Public Health 2021, 18, 2621. [Google Scholar] [CrossRef] [PubMed]
- Nejad, J.H.; Heiat, M.; Hosseini, M.J.; Allahyari, F.; Lashkari, A.; Torabi, R.; Ranjbar, R. Guillain-Barré Syndrome Associated with COVID-19: A Case Report Study. J. Neurovirol. 2021. [Google Scholar] [CrossRef] [PubMed]
- Gargiulo, C.; Hai, N.T.; Nguyen, K.C.; Kim, N.D.; Van, T.N.; Tuan, A.L.; Abe, K.; Flores, V.; Shiffman, M. Autologous Peripheral Blood Stem Cells and γ/δ T Cells May Improve Immunity in Treating Secondary Bacteremic Infection in HIV Infected Patient. Stem Cell Discov. 2015, 5, 48. [Google Scholar] [CrossRef] [Green Version]
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Balzanelli, M.G.; Distratis, P.; Dipalma, G.; Vimercati, L.; Inchingolo, A.D.; Lazzaro, R.; Aityan, S.K.; Maggiore, M.E.; Mancini, A.; Laforgia, R.; et al. Sars-CoV-2 Virus Infection May Interfere CD34+ Hematopoietic Stem Cells and Megakaryocyte–Erythroid Progenitors Differentiation Contributing to Platelet Defection towards Insurgence of Thrombocytopenia and Thrombophilia. Microorganisms 2021, 9, 1632. https://doi.org/10.3390/microorganisms9081632
Balzanelli MG, Distratis P, Dipalma G, Vimercati L, Inchingolo AD, Lazzaro R, Aityan SK, Maggiore ME, Mancini A, Laforgia R, et al. Sars-CoV-2 Virus Infection May Interfere CD34+ Hematopoietic Stem Cells and Megakaryocyte–Erythroid Progenitors Differentiation Contributing to Platelet Defection towards Insurgence of Thrombocytopenia and Thrombophilia. Microorganisms. 2021; 9(8):1632. https://doi.org/10.3390/microorganisms9081632
Chicago/Turabian StyleBalzanelli, Mario Giosuè, Pietro Distratis, Gianna Dipalma, Luigi Vimercati, Alessio Danilo Inchingolo, Rita Lazzaro, Sergey Khachatur Aityan, Maria Elena Maggiore, Antonio Mancini, Rita Laforgia, and et al. 2021. "Sars-CoV-2 Virus Infection May Interfere CD34+ Hematopoietic Stem Cells and Megakaryocyte–Erythroid Progenitors Differentiation Contributing to Platelet Defection towards Insurgence of Thrombocytopenia and Thrombophilia" Microorganisms 9, no. 8: 1632. https://doi.org/10.3390/microorganisms9081632