High Numbers of CD163-Positive Macrophages in the Fibrotic Region of Exuberant Granulation Tissue in Horses
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Horses
2.2. Wounds
2.2.1. Experimental Wounds
2.2.2. EGT Wounds
2.3. Histology
2.3.1. Histological Staining
2.3.2. Immunohistochemical Stainings
2.4. Image Acquisition and Analysis
2.5. Statistics
3. Results
3.1. MAC387 Staining
3.2. CD163 Staining
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Horse | Wound Age (Days) | Affected Limb | Localization EGT | Horse Age | Horse Weight (kg) |
---|---|---|---|---|---|
1 | 23 | RH | Distal dorsal tarsus | ~8 years | 600 |
2 | 26 | LH | Distal plantar tarsus | ~2 years | 405 |
3 | 16 | RH | Distal dorsal tarsus | ~6 years | 610 |
4 | 26 | LH | Metatarsus both lateral and medial | ~2 months | / |
5 | Presented at the clinic with an old wound, exact age of wound was unknown | RH | Medial tibia | ~1 year | 340 |
6 | 30 | RF | Carpus | ~11 years | 635 |
7 | Presented at the clinic with an old wound, exact age of wound was unknown | RH | Tarsus + metatarsus | ~11 years | 593 |
8 | 66 | LF | Fetlock | ~14 years | 480 |
9 | 17 | LH | Fetlock | ~11 years | / |
10 | Presented at the clinic with an old wound, exact age of wound was unknown | RF | Metacarpus | ~9 years | / |
11 | 9 | LH | Metacarpus | ~5 years | 520 |
12 | 20 | RH | Tarsus | ~5 years | 465 |
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Du Cheyne, C.; Martens, A.; De Spiegelaere, W. High Numbers of CD163-Positive Macrophages in the Fibrotic Region of Exuberant Granulation Tissue in Horses. Animals 2021, 11, 2728. https://doi.org/10.3390/ani11092728
Du Cheyne C, Martens A, De Spiegelaere W. High Numbers of CD163-Positive Macrophages in the Fibrotic Region of Exuberant Granulation Tissue in Horses. Animals. 2021; 11(9):2728. https://doi.org/10.3390/ani11092728
Chicago/Turabian StyleDu Cheyne, Charis, Ann Martens, and Ward De Spiegelaere. 2021. "High Numbers of CD163-Positive Macrophages in the Fibrotic Region of Exuberant Granulation Tissue in Horses" Animals 11, no. 9: 2728. https://doi.org/10.3390/ani11092728