SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death
Abstract
:1. Introduction
2. Similarities of the Clinical Course of Influenza- and the Clinical Course of Symptomatic SARS-CoV-2 Infections
3. SARS-CoV-2 Infection, Clinical Course in Hospitalized Patients, and Serum Cytokine/Chemokine Levels
Possible Explanation for Increased Serum Levels of Acute-Phase Cytokines/Chemokines as a Sign of Tissue Damage during Hospitalization
4. Mortality Risk Scores in Symptomatic, Hospitalized, SARS-CoV-2-Infected Patients
5. How to Define the Cause of Death
6. Importance of Fluid Homeostasis for Pulmonal Physiology
- (a)
- Dehydration when the total body fluid is significantly reduced compared to the age-specific hydration status (which is already reduced compared to that of the young);
- (b)
- Excess of body fluid (overhydration) when the amount of fluid in the body is higher than normal.
7. First Clinical and Experimental Report of the Consequences of Dehydration for Pulmonary and Systemic Circulation
8. Other Experimental Models of Pulmonary Distress and Hyaline Membrane Diseases
9. First Viral Acute Respiratory Distress Syndrome as Post-Influenza “Pneumonia”
10. Respiratory Distress Syndrome, Pulmonary Hyaline Membrane Disease, Becomes Acute Respiratory Distress Syndrome (ARDS)
- ARDS due to underlying (assumed) pulmonary disease.
- ARDS secondary to extrapulmonary disease which manifests with interstitial edema and alveolar collapse.
11. Modern Developments on Morphological Diagnosis of ARDS as a Pulmonary Distress Status from a Different Origin: The Combination of New Imaging Techniques and Pathology
12. How SARS-CoV-2 Infection of the Nose Leads to ARDS, Cardiac Arrest, and Death
- Primary.
- Contributing.
13. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Ramadori, G.P. SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death. Med. Sci. 2022, 10, 58. https://doi.org/10.3390/medsci10040058
Ramadori GP. SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death. Medical Sciences. 2022; 10(4):58. https://doi.org/10.3390/medsci10040058
Chicago/Turabian StyleRamadori, Giuliano Pasquale. 2022. "SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death" Medical Sciences 10, no. 4: 58. https://doi.org/10.3390/medsci10040058