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Medical Sciences, Volume 6, Issue 3

2018 September - 29 articles

Cover Story: Gut microbiota colonization during the first months of life is a complex and essential process that develops in parallel with the maturation of the immune system. Alterations during this period may have direct effects on health outcomes later in life. In this review, we summarize the influence of early gut microbiota colonization on the maturation of the immune system and health during the first 1000 days of life. Evidence of the influence of perinatal factors, such as antibiotic intake, mode of delivery, and breastfeeding, on balanced gut immunity development were also addressed.View Paper here.
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Articles (29)

  • Article
  • Open Access
5 Citations
3,824 Views
7 Pages

19 September 2018

Arrhythmogenic right ventricular dysplasia (ARVD) is an abnormality in the right side of the heart that may lead to sudden death. The study aims to compare cardiac MRI (magnetic resonance imaging findings) with echocardiography in patients with ARVD....

  • Feature Paper
  • Review
  • Open Access
144 Citations
12,257 Views
9 Pages

Gut–Liver Axis: How Do Gut Bacteria Influence the Liver?

  • Peter Christopher Konturek,
  • Igor Alexander Harsch,
  • Kathrin Konturek,
  • Monic Schink,
  • Thomas Konturek,
  • Markus F. Neurath and
  • Yurdaguel Zopf

17 September 2018

Chronic liver diseases are a major cause of morbidity and mortality worldwide. Recently, gut dysbiosis was identified as an important factor in the pathogenesis of liver diseases. The relationship between gut microbiota and the liver is still not wel...

  • Review
  • Open Access
4 Citations
4,890 Views
6 Pages

14 September 2018

Sleep disorders are common in several psychiatric disorders, including schizophrenia. In the pediatric population, the relationship between sleep and psychosis is not completely understood due to limited research studies investigating the link. Insom...

  • Review
  • Open Access
7 Citations
4,559 Views
10 Pages

14 September 2018

Sleep is essential to human development. Poor sleep can have significant effects on cognition, learning and memory, physical and behavioral health, and social-emotional well-being. This paper highlights the prevalence of common pediatric sleep proble...

  • Review
  • Open Access
14 Citations
17,235 Views
21 Pages

Apolipoprotein E Epsilon 4 Genotype, Mild Traumatic Brain Injury, and the Development of Chronic Traumatic Encephalopathy

  • Hansen Deng,
  • Angel Ordaz,
  • Pavan S. Upadhyayula,
  • Eva M. Gillis-Buck,
  • Catherine G. Suen,
  • Caroline G. Melhado,
  • Nebil Mohammed,
  • Troy Lam and
  • John K. Yue

14 September 2018

The annual incidence of mild traumatic brain injury (MTBI) is 3.8 million in the USA with 10–15% experiencing persistent morbidity beyond one year. Chronic traumatic encephalopathy (CTE), a neurodegenerative disease characterized by accumulatio...

  • Article
  • Open Access
1 Citations
3,510 Views
9 Pages

12 September 2018

In idiopathic pulmonary fibrosis (IPF) breathing pattern changes with disease progress. This study aims to determine if unsupervised hierarchal cluster analysis (HCA) can be used to define airflow profile differences in people with and without IPF. T...

  • Review
  • Open Access
12 Citations
5,579 Views
7 Pages

11 September 2018

In an era of precision medicine, it seems regressive that we do not use stratified approaches to direct treatment of oral corticosteroids during an exacerbation of chronic obstructive pulmonary disease (COPD). This is despite evidence suggesting that...

  • Review
  • Open Access
36 Citations
11,193 Views
20 Pages

Diagnosis of Idiopathic Pulmonary Fibrosis: Differential Diagnosis

  • Myriam Aburto,
  • Inmaculada Herráez,
  • David Iturbe and
  • Ana Jiménez-Romero

4 September 2018

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fibrotic interstitial lung disease of unknown origin with a characteristic imaging and histologic pattern called usual interstitial pneumonia (UIP). The diagnosis of IPF is a complex...

  • Review
  • Open Access
53 Citations
18,056 Views
12 Pages

Insomnia in Adolescence

  • Innessa Donskoy and
  • Darius Loghmanee

1 September 2018

Adolescent insomnia is a common condition that negatively impacts a developing young adult’s mental and physical health. While the treatment of adult insomnia has been standardized, the treatment of pediatric insomnia is very practitioner-depen...

  • Review
  • Open Access
4,153 Views
13 Pages

30 August 2018

A search for the “magic bullet”, a molecule, the targeting abilities of which could stop the migration of tumor cells, is currently underway, but remains in the early stages. There are still many unknowns regarding the cell migration. The...

  • Review
  • Open Access
21 Citations
8,236 Views
13 Pages

Comorbidities and Complications in Idiopathic Pulmonary Fibrosis

  • Esteban Cano-Jiménez,
  • Fernanda Hernández González and
  • Guadalupe Bermudo Peloche

30 August 2018

Though idiopathic pulmonary fibrosis (IPF) is characterized by single-organ involvement, many comorbid conditions occur within other organ systems. Patients with IPF may present during evolution different complications and comorbidities that influenc...

  • Review
  • Open Access
95 Citations
17,491 Views
20 Pages

24 August 2018

Recently, there has been a substantial increase in the number of studies focused upon connecting the gut microbiome with cases of central nervous system (CNS) autoimmunity. Multiple sclerosis (MS) is a neurodegenerative autoimmune disorder of the CNS...

  • Review
  • Open Access
57 Citations
8,181 Views
16 Pages

Lung Transplantation in Idiopathic Pulmonary Fibrosis

  • Rosalía Laporta Hernandez,
  • Myriam Aguilar Perez,
  • María Teresa Lázaro Carrasco and
  • Piedad Ussetti Gil

23 August 2018

Despite the advances in recent years in the treatment of idiopathic pulmonary fibrosis (IPF), it continues to be a progressive disease with poor prognosis. In selected patients, lung transplantation may be a treatment option, with optimal results in...

  • Perspective
  • Open Access
14 Citations
4,595 Views
15 Pages

22 August 2018

Cultural changes are needed in medicine if the benefits of technological advances are to benefit healthcare users. The Digital Health Manifesto of ‘medical futurist’ doctor Bertalan Meskó and ‘e-patient’ Dave deBronkart...

  • Brief Report
  • Open Access
7 Citations
5,541 Views
6 Pages

Improving Blood Transfusion Practices in a Community Hospital Setting: Our Experience with Real-Time Clinical Decision Support

  • Muhammad Sardar,
  • Muhammad Azharuddin,
  • Ananta Subedi,
  • Prateek Ghatage,
  • Doantarang Du and
  • Arpad Szallasi

22 August 2018

There is good evidence that 50% or more of red blood cell (RBC) transfusions are unnecessary. To curtail inappropriate RBC transfusions at our hospital, real-time clinical decision support was implemented in our electronic medical record (EMR) that a...

  • Article
  • Open Access
15 Citations
4,389 Views
10 Pages

Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy

  • Rebecca R. Weicht,
  • Chad R. Schultz,
  • Dirk Geerts,
  • Katie L. Uhl and
  • André S. Bachmann

16 August 2018

Osteosarcoma (OS) is the most common bone tumor in children. Polyamines (PAs) are ubiquitous cations involved in many cell processes including tumor development, invasion and metastasis. In other pediatric cancer models, inhibition of the PA biosynth...

  • Article
  • Open Access
5 Citations
6,364 Views
8 Pages

Should Mumps Be Higher Up on the Public Health Agenda in India? A Concern for Global Health Security

  • Syed Manzoor Kadri,
  • Saleem-ur Rehman,
  • Kausar Rehana,
  • Ailbhe Helen Brady and
  • Vijay Kumar Chattu

7 August 2018

Mumps is a public health problem on a global scale caused by mumps virus, a member of family paramyxoviridae. An effective form of vaccination exists and is incorporated into routine immunization schedules in over 100 countries, usually in the form o...

  • Review
  • Open Access
13 Citations
5,073 Views
8 Pages

7 August 2018

Chronic obstructive pulmonary disease (COPD) is the second leading cause of emergency department (ED) admissions to hospital, and nearly a third of patients with acute exacerbation (AE) of COPD are re-admitted to hospital within 28 days after dischar...

  • Review
  • Open Access
3 Citations
5,857 Views
13 Pages

3 August 2018

The devastating growth in the worldwide frequency of neurocognitive disorders and its allied difficulties, such as decline in memory, spatial competency, and ability to focus, poses a significant psychological public health problem. Inhibitor of diff...

  • Article
  • Open Access
22 Citations
6,416 Views
10 Pages

Occurrence of Surgical Site Infections at a Tertiary Healthcare Facility in Abuja, Nigeria: A Prospective Observational Study

  • Ahmed Olowo-okere,
  • Yakubu Kokori Enevene Ibrahim,
  • Ali Samuel Sani and
  • Busayo Olalekan Olayinka

Surgical site infection (SSI) is one of the most frequent complications of surgical interventions. Several factors have been identified as major determinants of occurrence of SSIs. The present study determined the occurrence and possible risk factors...

  • Review
  • Open Access
20 Citations
6,940 Views
13 Pages

Causes of Pulmonary Fibrosis in the Elderly

  • Cecilia López-Ramírez,
  • Lionel Suarez Valdivia and
  • Jose Antonio Rodríguez Portal

Idiopathic pulmonary fibrosis (IPF) is the most common and most lethal type of idiopathic interstitial pneumonia. It is a chronic, aging-associated lung disease characterized by fibrotic foci and inflammatory infiltrates, with no cure and very limite...

  • Review
  • Open Access
20 Citations
9,057 Views
18 Pages

Comorbidities, Complications and Non-Pharmacologic Treatment in Idiopathic Pulmonary Fibrosis

  • Paloma Millan-Billi,
  • Candela Serra,
  • Ana Alonso Leon and
  • Diego Castillo

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. The treatment is challenging and nowadays a comprehensive approach based not only in pharmacological strategies is necessary. Identification and control of comorbidities...

  • Article
  • Open Access
6 Citations
4,465 Views
9 Pages

The Use of Biochemical and Biophysical Markers in Early Screening for Preeclampsia in Mongolia

  • Urjindelger Tserensambuu,
  • Ariunbold Chuluun-Erdene,
  • Munkhtsetseg Janlav and
  • Erkhembaatar Tudevdorj

Preeclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality, particularly in developing countries. In Mongolia, preeclampsia and eclampsia have occurred among pregnancy complications at a rate of 25% in recent years. Recent s...

  • Feature Paper
  • Review
  • Open Access
108 Citations
15,930 Views
23 Pages

Gut Microbiota and Mucosal Immunity in the Neonate

  • Majda Dzidic,
  • Alba Boix-Amorós,
  • Marta Selma-Royo,
  • Alex Mira and
  • Maria Carmen Collado

Gut microbiota colonization is a complex, dynamic, and step-wise process that is in constant development during the first years of life. This microbial settlement occurs in parallel with the maturation of the immune system, and alterations during thi...

  • Article
  • Open Access
12 Citations
4,649 Views
11 Pages

Prediabetes is the precursor stage of diabetes mellitus and is also considered to be a risk factor for the development of cardiovascular disease. Atherogenic indices have been used for assessment of risk for cardiovascular disease development. To dat...

  • Review
  • Open Access
44 Citations
8,950 Views
21 Pages

Apoptosis: Activation and Inhibition in Health and Disease

  • Sandra Georgina Solano-Gálvez,
  • Jack Abadi-Chiriti,
  • Luis Gutiérrez-Velez,
  • Eduardo Rodríguez-Puente,
  • Enrique Konstat-Korzenny,
  • Diego-Abelardo Álvarez-Hernández,
  • Giorgio Franyuti-Kelly,
  • Laila Gutiérrez-Kobeh and
  • Rosalino Vázquez-López

There are many types of cell death, each involving multiple and complex molecular events. Cell death can occur accidentally when exposed to extreme physical, chemical, or mechanical conditions, or it can also be regulated, which involves a geneticall...

  • Article
  • Open Access
9 Citations
4,674 Views
9 Pages

Elevated Proangiogenic Markers are Associated with Vascular Complications within Ghanaian Sickle Cell Disease Patients

  • Charles Antwi-Boasiako,
  • Emmanuel Frimpong,
  • Ben Gyan,
  • Eric Kyei-Baafour,
  • Fredericka Sey,
  • Bartholomew Dzudzor,
  • Mubarak Abdul-Rahman,
  • Gifty B. Dankwah,
  • Kate H. Otu and
  • Eric S. Donkor
  • + 3 authors

Sickle cell disease (SCD) is an inherited blood disorder that can result in vasculopathy and end organ damage. Angiogenesis has been implicated as a key contributing factor to vascular mediated tissue injury in SCD. The relative plasma levels of angi...

  • Review
  • Open Access
94 Citations
14,489 Views
26 Pages

Circadian Rhythm and Alzheimer’s Disease

  • Jan Homolak,
  • Monika Mudrovčić,
  • Barbara Vukić and
  • Karlo Toljan

Alzheimer’s disease (AD) is a neurodegenerative disorder with a growing epidemiological importance characterized by significant disease burden. Sleep-related pathological symptomatology often accompanies AD. The etiology and pathogenesis of disrupted...

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Med. Sci. - ISSN 2076-3271