Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties

Park, Sunho; Kim, Hyeran; Choi, Kyoung Soon; Ji, Min-Kyung; Kim, Sujin; Gwon, Yonghyun; Park, Chan; Kim, Jangho; Lim, Hyun-Pil

doi:10.3390/app10144888

Open AccessCommunication

Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties

by

Sunho Park

^1,†,

Hyeran Kim

^2,†,

Kyoung Soon Choi

³

,

Min-Kyung Ji

⁴,

Sujin Kim

¹,

Yonghyun Gwon

¹,

Chan Park

²

,

Jangho Kim

^1,* and

Hyun-Pil Lim

^2,*

¹

Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju 61186, Korea

²

Department of Prosthodontics, School of Dentistry, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju 61186, Korea

³

National Research Facilities & Equipment Center (NFEC), Korea Basic Science Institute (KBSI), 169-148 Gwahak-ro, Yuseong-gu, Daejeon 34133, Korea

⁴

Optoelectronics Convergence Research Center, Chonnam National University, Gwangju 61186, Korea

^*

Authors to whom correspondence should be addressed.

^†

S.P. and H.K. contributed equally to this work.

Appl. Sci. 2020, 10(14), 4888; https://doi.org/10.3390/app10144888

Submission received: 12 June 2020 / Revised: 7 July 2020 / Accepted: 13 July 2020 / Published: 16 July 2020

(This article belongs to the Special Issue Biomaterials and Biofabrication)

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Abstract

Dental implants are widely used tooth replacement tools owing to their good oral rehabilitation and reconstruction capacities. Since dental implants are designed as a replacement for natural teeth, multi-functional abilities are desired to achieve successful implant treatment with improved osseointegration through promotion of mammalian cell activity and prevention of bacterial cell activity. In this study, we developed a graphene–chitosan hybrid dental implant (GC hybrid implant) using various concentrations of graphene, which demonstrated the different surface properties including increased wettability and roughness. Importantly, the GC hybrid implant under the optimal condition (i.e., 1% GC hybrid implant) could significantly promote osteoblast proliferation while reducing biofilm formation and bacterial activity. Our study demonstrates the potential of using this GC hybrid implant as a new type of dental implant, which can offer an effective design for the fabrication of advanced dental implants.

Keywords: dental implant; graphene oxide; chitosan; titanium

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MDPI and ACS Style

Park, S.; Kim, H.; Choi, K.S.; Ji, M.-K.; Kim, S.; Gwon, Y.; Park, C.; Kim, J.; Lim, H.-P. Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties. Appl. Sci. 2020, 10, 4888. https://doi.org/10.3390/app10144888

AMA Style

Park S, Kim H, Choi KS, Ji M-K, Kim S, Gwon Y, Park C, Kim J, Lim H-P. Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties. Applied Sciences. 2020; 10(14):4888. https://doi.org/10.3390/app10144888

Chicago/Turabian Style

Park, Sunho, Hyeran Kim, Kyoung Soon Choi, Min-Kyung Ji, Sujin Kim, Yonghyun Gwon, Chan Park, Jangho Kim, and Hyun-Pil Lim. 2020. "Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties" Applied Sciences 10, no. 14: 4888. https://doi.org/10.3390/app10144888

APA Style

Park, S., Kim, H., Choi, K. S., Ji, M.-K., Kim, S., Gwon, Y., Park, C., Kim, J., & Lim, H.-P. (2020). Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties. Applied Sciences, 10(14), 4888. https://doi.org/10.3390/app10144888

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties

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