Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort
, Koo Han Yoo 1,†, Sinyeong Lee 1, Jin Kyu Oh 1, Hyuk Jin Cho 1, Sang Youn Kim 1, Gyeong Eun Min 1, Sang Hyub Lee 1, Wansuk Kim 1, Shufeng Li 1,2, Wuran Wei 1, Jianlin Huang 1, David R. Brown 1, Kyle Spradling 1, Satvir Basran 1, Federico Belladelli 1, Riccardo Autorino 3, Savio Domenico Pandolfo 3, Simone Crivellaro 4, Felice Crocetto 5, Matteo Ferro 6, Vincenzo Asero 2, Carlo Maria Scornajenghi 2, Eugenio Bologna 2, Alessandro Sciarra 2, Stefano Salciccia 2, add
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Round 1
Reviewer 1 Report
Del Giudice and co-authors conducted a retrospective observational cohort-study with the purpose to identify the main characteristics of septic patients with urinary tract obstruction due to urinary stones and analyze risk factors.
This is an interesting topic, and considering the burden of sepsis on healthcare systems, I believe that the results here described may have a clinical guidance significance.
Therefore, I recommend the Editor consider publishing Del Giudice and co-authors' work.
Author Response
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Author Response File: 
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Reviewer 2 Report
This retrospective Analysis explain the risk factors and characteristics of sepsis or APN combined with ureteral stone.
This is useful information and I accept in current format.
Author Response
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Reviewer 3 Report
Dear Authors,
I would like to congratulate you on very interesting work. Before recommending it to the further editing process I would like to ask you about developing financial aspect in ‘Results’ section and writing a separate paragraph on it in ‘Discussion’ section as well as adding relevant literature.
Best regards.
Author Response
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Reviewer 4 Report
Characteristics of Sepsis or Acute Pyelonephritis Combined 2 with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort
Summary
This is an interesting retrospective cohort study of the characteristics of sepsis or acute pyelonephritis combined with ureteral stone in the United States. The author reviewed about 467,502 patients from a database. The conclusion is that a history of urinary tract infection and the female gender are the highest individual risk factors for the development of sepsis or APN in patients with ureteral calculi—the high odds ratio of 11.31 for a history of UTI and 2.73 for female gender establishes this fact .
Strength
· Very detailed presentation
· Statistical analysis is adequate
· Robust database – this is the major strength in this paper that gives it scientific soundness
Weakness
· Lacks originality. The conclusion is already a well-known fact. The paper is just to buttress an already-established fact. I will suggest that the authors make a case for the uniqueness of this research in terms of the conclusion drawn from the data.
Author Response
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Author Response File: Author Response.pdf
