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Review

Recent Studies on the Healing Properties of Eicosapentaenoic Acid

by
Maria Dospra
1,
Panagoula Pavlou
1,2,
Spyridon Papageorgiou
1,2 and
Athanasia Varvaresou
1,2,*
1
Sector of Aesthetics and Cosmetic Science, Department of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, 28 Ag. Spyridonos Str., Panepistimioupolis Egaleo Park, 12243 Athens, Greece
2
Laboratory of Chemistry-Biochemistry-Cosmetic Science, Department of Biomedical Sciences, University of West Attica, 28 Ag. Spyridonos Str., Panepistimioupolis Egaleo Park, 12243 Athens, Greece
*
Author to whom correspondence should be addressed.
Appl. Sci. 2024, 14(13), 5884; https://doi.org/10.3390/app14135884
Submission received: 5 June 2024 / Revised: 25 June 2024 / Accepted: 2 July 2024 / Published: 5 July 2024
(This article belongs to the Special Issue Cosmetics Ingredients Research)

Abstract

Patients with diabetes, the elderly, and those who have certain inherited conditions are particularly vulnerable to atypical wound healing with lingering repercussions. Remarkably, the current remedies are insufficient since, despite the plethora of wound healing options, only limited efficacy is observed. This review is a bibliographic survey on eicosapentaenoic acid and its healing effects. It has been investigated in terms of its source of origin, structure, physico-chemical properties, and studies where healing action is demonstrated. Fatty acids, found in all layers of the skin, modify cell function and the synthesis of eicosanoids, reactive oxygen species, and cytokines, which affects skin structure and immunological condition. As a result, fatty acids influence both the inflammatory response and the wound-healing process. EPA is one of the dietary lipids that has a variety of health advantages. It functions in anti-inflammatory processes and the firmness of cell membranes and is integrated into numerous bodily parts. EPA has a crucial role in healthy fetal development and aging. It is a precursor to numerous metabolites that are powerful lipid mediators and are regarded by many researchers as being helpful in the treatment or prevention of several disorders. EPA supplement is used after surgery to lessen infections, accelerate wound healing, and speed up recovery, although, according to other researchers, the oral administration of omega-3 fatty acids, particularly the DHA and EPA combination, significantly slows down the healing of wounds and disrupts the structure of collagen through several mechanisms. The controversy in the reported literature is discussed and new technologies useful for the improvement of the wound healing process are also reported.
Keywords: eicosapentaenoic acid; wound healing; diabetes; skin; oral administration eicosapentaenoic acid; wound healing; diabetes; skin; oral administration

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MDPI and ACS Style

Dospra, M.; Pavlou, P.; Papageorgiou, S.; Varvaresou, A. Recent Studies on the Healing Properties of Eicosapentaenoic Acid. Appl. Sci. 2024, 14, 5884. https://doi.org/10.3390/app14135884

AMA Style

Dospra M, Pavlou P, Papageorgiou S, Varvaresou A. Recent Studies on the Healing Properties of Eicosapentaenoic Acid. Applied Sciences. 2024; 14(13):5884. https://doi.org/10.3390/app14135884

Chicago/Turabian Style

Dospra, Maria, Panagoula Pavlou, Spyridon Papageorgiou, and Athanasia Varvaresou. 2024. "Recent Studies on the Healing Properties of Eicosapentaenoic Acid" Applied Sciences 14, no. 13: 5884. https://doi.org/10.3390/app14135884

APA Style

Dospra, M., Pavlou, P., Papageorgiou, S., & Varvaresou, A. (2024). Recent Studies on the Healing Properties of Eicosapentaenoic Acid. Applied Sciences, 14(13), 5884. https://doi.org/10.3390/app14135884

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