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Open AccessArticle
Efficacy and Tolerability of a Microneedling Device Plus Exosomes for Treating Melasma
by
Ilaria Proietti
Ilaria Proietti 1,†
,
Chiara Battilotti
Chiara Battilotti 1,*,†
,
Francesca Svara
Francesca Svara 1,†,
Carlotta Innocenzi
Carlotta Innocenzi 1,
Alessandra Spagnoli
Alessandra Spagnoli 2 and
Concetta Potenza
Concetta Potenza 1
1
Dermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, Italy
2
Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Appl. Sci. 2024, 14(16), 7252; https://doi.org/10.3390/app14167252 (registering DOI)
Submission received: 12 July 2024
/
Revised: 31 July 2024
/
Accepted: 16 August 2024
/
Published: 17 August 2024
Abstract
Melasma is a challenging skin condition which involves both structural and functional skin alterations. Despite the availability of various treatment options, the management remains complex. This is the first study to investigate topical application of Rosa Damascena stem cell exosomes when used concomitantly with microneedling in women and men with facial melasma. We recruited 20 subjects with Fitzpatrick skin types I-III, exhibiting melasma of varying severity. The modified Melasma Area and Severity Index (mMASI) and Global Aesthetic Improvement Scale (GAIS) were utilized to evaluate treatment response. The treatment protocol involved microneedling followed by exosome application over four or five sessions, at 4-week intervals. Ninety percent of subjects demonstrated a significant improvement in mMASI scores, while only 10% showed no change. GAIS assessment further supports overall improvement, with just 10% categorized as “not changed”. Tolerability was favorable, with mild, transient side effects. Our findings suggest promising outcomes with this combined therapy, underscoring its potential as a safe and effective approach for treating melasma, particularly in severe and moderate cases. However, further research with larger sample sizes and control arms is warranted to validate these findings and explore long-term efficacy.
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MDPI and ACS Style
Proietti, I.; Battilotti, C.; Svara, F.; Innocenzi, C.; Spagnoli, A.; Potenza, C.
Efficacy and Tolerability of a Microneedling Device Plus Exosomes for Treating Melasma. Appl. Sci. 2024, 14, 7252.
https://doi.org/10.3390/app14167252
AMA Style
Proietti I, Battilotti C, Svara F, Innocenzi C, Spagnoli A, Potenza C.
Efficacy and Tolerability of a Microneedling Device Plus Exosomes for Treating Melasma. Applied Sciences. 2024; 14(16):7252.
https://doi.org/10.3390/app14167252
Chicago/Turabian Style
Proietti, Ilaria, Chiara Battilotti, Francesca Svara, Carlotta Innocenzi, Alessandra Spagnoli, and Concetta Potenza.
2024. "Efficacy and Tolerability of a Microneedling Device Plus Exosomes for Treating Melasma" Applied Sciences 14, no. 16: 7252.
https://doi.org/10.3390/app14167252
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