Efficacy, Tolerability, and Face Lipidomic Modification of New Regimen with Cleanser and Corrective Serum in Women with Acne-Prone Skin
Abstract
:1. Introduction
1.1. Adult Female Acne
1.2. Etiopathogenesis of AFA
1.3. Skin Barrier Alteration in A. vulgaris
1.4. Quantitative and Qualitative Change in Sebum
1.5. Study Aim
2. Materials and Methods
2.1. Study Design
2.2. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Tanghetti, E.A.; Kawata, A.K.; Daniels, S.R.; Yeomans, K.; Burk, C.T.; Callender, V.D. Understanding the Burden of Adult Female Acne. J. Clin. Aesthetic Dermatol. 2014, 7, 22–30. [Google Scholar]
- Rocha, M.A.; Bagatin, E. Adult-Onset Acne: Prevalence, Impact, and Management Challenges. Clin. Cosmet. Investig. Dermatol. 2018, 11, 59–69. [Google Scholar] [CrossRef] [PubMed]
- Kutlu, Ö.; Karadağ, A.S.; Wollina, U. Adult Acne versus Adolescent Acne: A Narrative Review with a Focus on Epidemiology to Treatment. Bras. Dermatol. 2023, 98, 75–83. [Google Scholar] [CrossRef] [PubMed]
- Bhate, K.; Williams, H.C. Epidemiology of Acne Vulgaris. Br. J. Dermatol. 2013, 168, 474–485. [Google Scholar] [CrossRef]
- Collier, C.N.; Harper, J.C.; Cantrell, W.C.; Wang, W.; Foster, K.W.; Elewski, B.E. The Prevalence of Acne in Adults 20 Years and Older. J. Am. Acad. Dermatol. 2008, 58, 56–59. [Google Scholar] [CrossRef] [PubMed]
- Tan, A.U.; Schlosser, B.J.; Paller, A.S. A Review of Diagnosis and Treatment of Acne in Adult Female Patients. Int. J. Womens Dermatol. 2018, 4, 56–71. [Google Scholar] [CrossRef]
- Bagatin, E.; de Freitas, T.H.P.; Rivitti-Machado, M.C.; Ribeiro, B.M.; Nunes, S.; da Rocha, M.A.D. Adult Female Acne: A Guide to Clinical Practice. Bras. Dermatol. 2019, 94, 62–75. [Google Scholar] [CrossRef]
- Kamangar, F.; Shinkai, K. Acne in the Adult Female Patient: A Practical Approach. Int. J. Dermatol. 2012, 51, 1162–1174. [Google Scholar] [CrossRef]
- Dréno, B.; Thiboutot, D.; Layton, A.M.; Berson, D.; Perez, M.; Kang, S. Large-scale International Study Enhances Understanding of an Emerging Acne Population: Adult Females. J. Eur. Acad. Dermatol. Venereol. 2015, 29, 1096–1106. [Google Scholar] [CrossRef]
- Kim, H.J.; Kim, Y.H. Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies. Int. J. Mol. Sci. 2024, 25, 5302. [Google Scholar] [CrossRef]
- Bhat, Y.; Latief, I.; Hassan, I. Update on Etiopathogenesis and Treatment of Acne. Indian. J. Dermatol. Venereol. Leprol. 2017, 83, 298. [Google Scholar] [CrossRef]
- Zouboulis, C.C.; Picardo, M.; Ju, Q.; Kurokawa, I.; Törőcsik, D.; Bíró, T.; Schneider, M.R. Beyond Acne: Current Aspects of Sebaceous Gland Biology and Function. Rev. Endocr. Metab. Disord. 2016, 17, 319–334. [Google Scholar] [CrossRef] [PubMed]
- Ramasamy, S.; Barnard, E.; Dawson, T.L.; Li, H. The Role of the Skin Microbiota in Acne Pathophysiology. Br. J. Dermatol. 2019, 181, 691–699. [Google Scholar] [CrossRef]
- Rocha, M.A.; Bagatin, E. Skin Barrier and Microbiome in Acne. Arch. Dermatol. Res. 2018, 310, 181–185. [Google Scholar] [CrossRef]
- Schachner, L.A.; Alexis, A.F.; Andriessen, A.; Berson, D.; Gold, M.; Goldberg, D.J.; Hu, S.; Keri, J.; Kircik, L.; Woolery-Lloyd, H. Insights into Acne and the Skin Barrier: Optimizing Treatment Regimens with Ceramide-containing Skincare. J. Cosmet. Dermatol. 2023, 22, 2902–2909. [Google Scholar] [CrossRef] [PubMed]
- Kurokawa, I.; Layton, A.M.; Ogawa, R. Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis. Dermatol. Ther. 2021, 11, 1129–1139. [Google Scholar] [CrossRef]
- Del Rosso JQ, L.J. The Clinical Relevance of Maintaining the Functional Integrity of the Stratum Corneum in Both Healthy and Disease-Affected Skin. J. Clin. Aesthet. Dermatol. 2011, 4, 22–42. [Google Scholar]
- Yamamoto, A.; Takenouchi, K.; Ito, M. Impaired Water Barrier Function in Acne Vulgaris. Arch. Dermatol. Res. 1995, 287, 214–218. [Google Scholar] [CrossRef]
- Pappas, A.; Kendall, A.C.; Brownbridge, L.C.; Batchvarova, N.; Nicolaou, A. Seasonal Changes in Epidermal Ceramides Are Linked to Impaired Barrier Function in Acne Patients. Exp. Dermatol. 2018, 27, 833–836. [Google Scholar] [CrossRef] [PubMed]
- Ottaviani, M.; Camera, E.; Picardo, M. Lipid Mediators in Acne. Mediat. Inflamm. 2010, 2010, 858176. [Google Scholar] [CrossRef]
- Carmina, E.; Dreno, B.; Lucky, W.A.; Agak, W.G.; Dokras, A.; Kim, J.J.; Lobo, R.A.; Ramezani Tehrani, F.; Dumesic, D. Female Adult Acne and Androgen Excess: A Report from the Multidisciplinary Androgen Excess and PCOS Committee. J. Endocr. Soc. 2022, 6, bvac003. [Google Scholar] [CrossRef]
- McGinley, K.J.; Webster, G.F.; Ruggieri, M.R.; Leyden, J.J. Regional Variations in Density of Cutaneous Propionibacteria: Correlation of Propionibacterium Acnes Populations with Sebaceous Secretion. J. Clin. Microbiol. 1980, 12, 672–675. [Google Scholar] [CrossRef]
- Csak, T.; Ganz, M.; Pespisa, J.; Kodys, K.; Dolganiuc, A.; Szabo, G. Fatty Acid and Endotoxin Activate Inflammasomes in Mouse Hepatocytes That Release Danger Signals to Stimulate Immune Cells. Hepatology 2011, 54, 133–144. [Google Scholar] [CrossRef] [PubMed]
- Li, Q.; Fang, H.; Dang, E.; Wang, G. The Role of Ceramides in Skin Homeostasis and Inflammatory Skin Diseases. J. Dermatol. Sci. 2020, 97, 2–8. [Google Scholar] [CrossRef] [PubMed]
- Ding, W.; Hu, Y.; Yu, X.; He, C.; Tian, Y. Analysis on the Difference of Skin Surface Lipids during Blue Light Therapy for Acne by Lipidomics. Biomed. Opt. Express 2022, 13, 3434. [Google Scholar] [CrossRef] [PubMed]
- Dias da Rocha, M.A.; Saint Aroman, M.; Mengeaud, V.; Carballido, F.; Doat, G.; Coutinho, A.; Bagatin, E. Unveiling the Nuances of Adult Female Acne: A Comprehensive Exploration of Epidemiology, Treatment Modalities, Dermocosmetics, and the Menopausal Influence. Int. J. Womens Health 2024, 16, 663–678. [Google Scholar] [CrossRef]
- Del Rosso, J.Q.; Harper, J.C.; Graber, E.M.; Thiboutot, D.; Silverberg, N.B.; Eichenfield, L.F. Status Report from the American Acne & Rosacea Society on Medical Management of Acne in Adult Women, Part 2: Topical Therapies. Cutis 2015, 96, 321–325. [Google Scholar]
- Hammill, C.; Vaillancourt, T. Acne and Its Association with Internalizing Problems. Dermatol. Rev. 2023, 4, 228–238. [Google Scholar] [CrossRef]
- Altunay, I.; Özkur, E.; Dalgard, F.; Gieler, U.; Aragones, L.; Lien, L.; Poot, F.; Jemec, G.; Misery, L.; Szabó, C.; et al. Psychosocial Aspects of Adult Acne: Data from 13 European Countries. Acta Derm. Venereol. 2020, 100, 5671. [Google Scholar] [CrossRef]
- Branisteanu, D.; Toader, M.; Porumb, E.; Serban, I.; Pinzariu, A.; Branisteanu, C.; Vicovan, A.; Dimitriu, A.; Fartusnic, I.-A.; Boda, D.; et al. Adult Female Acne: Clinical and Therapeutic Particularities (Review). Exp. Ther. Med. 2021, 23, 151. [Google Scholar] [CrossRef]
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Vitale, M.; Gómez-Sánchez, M.J.; Vicente, M.H.; Colombo, F.; Milani, M. Efficacy, Tolerability, and Face Lipidomic Modification of New Regimen with Cleanser and Corrective Serum in Women with Acne-Prone Skin. Appl. Sci. 2024, 14, 7799. https://doi.org/10.3390/app14177799
Vitale M, Gómez-Sánchez MJ, Vicente MH, Colombo F, Milani M. Efficacy, Tolerability, and Face Lipidomic Modification of New Regimen with Cleanser and Corrective Serum in Women with Acne-Prone Skin. Applied Sciences. 2024; 14(17):7799. https://doi.org/10.3390/app14177799
Chicago/Turabian StyleVitale, Maria, María José Gómez-Sánchez, Mencía Hermosa Vicente, Francesca Colombo, and Massimo Milani. 2024. "Efficacy, Tolerability, and Face Lipidomic Modification of New Regimen with Cleanser and Corrective Serum in Women with Acne-Prone Skin" Applied Sciences 14, no. 17: 7799. https://doi.org/10.3390/app14177799