Box-Jenkins Transfer Function Modelling for Reliable Determination of VO2 Kinetics in Patients with COPD
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Exercise Testing
2.3. Data Pre-Processing
2.4. Kinetic Analyses
2.5. Statistical Analysis
3. Results
3.1. Exponential Modelling
3.2. Box-Jenkins Transfer Function Modelling
3.3. Kinetic Features
4. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Value Mean (SD) | |
---|---|
Age (years) | 63 (7) |
Body mass index (kg/m2) | 26 (5) |
Forced expiratory volume in 1 second (FEV1) % predicted | 48 (14) |
Forced vital capacity (FVC) % predicted | 105 (18) |
FEV1/FVC (%) | 37 (13) |
Transfer factor for carbon monoxide % predicted | 55 (15) |
Partial pressure of oxygen (kPa) | 8.8 (1.8) |
Partial pressure of carbon dioxide (kPa) | 5.3 (0.7) |
Modified Medical Research Council dyspnoea scores (scores 1-2-3) | 2-14-2 |
CPET maximal cycling load % predicted [18] | 50 (23) |
CPET maximal oxygen uptake (ml/min) | 1133 (231) |
CPET maximal oxygen uptake % predicted [18] | 55 (21) |
CWRT cycling load (W) | 57 (16) |
CWRT endurance time (s) | 243 (81) |
Order D(z−1) | ||||
---|---|---|---|---|
1 | 2 | 3 | ||
Order C(z−1) | 0 | −6.94 (2.31) | −5.69 (2.12) | |
2.8 (1.3) | 2.1 (1.1) | |||
1 | −6.82 (2.91) | −6.20 (2.11) | ||
2.5 (1.7) | 2.0 (2.6) | |||
2 | −6.75 (2.63) | −6.21 (2.69) | ||
2.1 (1.6) | 2.0 (1.6) | |||
3 |
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Buekers, J.; Theunis, J.; Peña Fernández, A.; Wouters, E.F.M.; Spruit, M.A.; De Boever, P.; Aerts, J.-M. Box-Jenkins Transfer Function Modelling for Reliable Determination of VO2 Kinetics in Patients with COPD. Appl. Sci. 2019, 9, 1822. https://doi.org/10.3390/app9091822
Buekers J, Theunis J, Peña Fernández A, Wouters EFM, Spruit MA, De Boever P, Aerts J-M. Box-Jenkins Transfer Function Modelling for Reliable Determination of VO2 Kinetics in Patients with COPD. Applied Sciences. 2019; 9(9):1822. https://doi.org/10.3390/app9091822
Chicago/Turabian StyleBuekers, Joren, Jan Theunis, Alberto Peña Fernández, Emiel F. M. Wouters, Martijn A. Spruit, Patrick De Boever, and Jean-Marie Aerts. 2019. "Box-Jenkins Transfer Function Modelling for Reliable Determination of VO2 Kinetics in Patients with COPD" Applied Sciences 9, no. 9: 1822. https://doi.org/10.3390/app9091822