Tau Protein Accumulation Trajectory-Based Brain Age Prediction in the Alzheimer’s Disease Continuum
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Image Acquisition and Processing
2.3. Brain Age Estimation
2.4. Statistical Analyses
3. Results
3.1. Subject Characteristics
3.2. Pathologic Tau Accumulation in AD Continuum
3.3. Brain Age Prediction and Its Gap
3.4. Associations between Brain Age Gap and Neuropsychological Assessments and the AD Biomarker
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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NC | MCI | AD | p | Post Hoc p | |||
---|---|---|---|---|---|---|---|
p1 | p2 | p3 | |||||
Number | 418 | 306 | 86 | - | - | - | - |
Sex (M/F) | 259/159 | 170/136 | 54/32 | 0.203 | 0.083 | 0.885 | 0.232 |
Age (years) | 72.7 ± 7.6 | 74.6 ± 7.3 | 76.9 ± 7.9 | <0.001 | 0.0014 | <0.001 | 0.341 |
Education (years) | 16.7 ± 2.2 | 16.4 ± 2.5 | 15.4 ± 2.5 | <0.001 | 0.231 | <0.001 | 0.003 |
APOE4 carriers (%) | 32.3 | 53.9 | 61.6 | - | - | - | - |
ADAS11 | 5.2 ± 2.5 | 9.7 ± 4.4 | 20.6 ± 8.6 | <0.001 | <0.001 | <0.001 | <0.001 |
ADAS13 | 8.2 ± 3.9 | 15.8 ± 6.8 | 31.5 ± 10.1 | <0.001 | <0.001 | <0.001 | <0.001 |
MMSE | 29.2 ± 1.0 | 27.3 ± 2.3 | 21.5 ± 4.2 | <0.001 | <0.001 | <0.001 | <0.001 |
MOCA | 26.2 ± 2.6 | 22.9 ± 3.2 | 16.3 ± 4.4 | <0.001 | <0.001 | <0.001 | <0.001 |
Merged tau SUVR | 1.14 ± 0.12 | 1.42 ± 0.45 | 1.71 ± 0.63 | <0.001 | <0.001 | <0.001 | <0.001 |
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Wang, M.; Wei, M.; Wang, L.; Song, J.; Rominger, A.; Shi, K.; Jiang, J., on behalf of the Alzheimer’s Disease Neuroimaging Initiative. Tau Protein Accumulation Trajectory-Based Brain Age Prediction in the Alzheimer’s Disease Continuum. Brain Sci. 2024, 14, 575. https://doi.org/10.3390/brainsci14060575
Wang M, Wei M, Wang L, Song J, Rominger A, Shi K, Jiang J on behalf of the Alzheimer’s Disease Neuroimaging Initiative. Tau Protein Accumulation Trajectory-Based Brain Age Prediction in the Alzheimer’s Disease Continuum. Brain Sciences. 2024; 14(6):575. https://doi.org/10.3390/brainsci14060575
Chicago/Turabian StyleWang, Min, Min Wei, Luyao Wang, Jun Song, Axel Rominger, Kuangyu Shi, and Jiehui Jiang on behalf of the Alzheimer’s Disease Neuroimaging Initiative. 2024. "Tau Protein Accumulation Trajectory-Based Brain Age Prediction in the Alzheimer’s Disease Continuum" Brain Sciences 14, no. 6: 575. https://doi.org/10.3390/brainsci14060575