Effectiveness and Tolerability of Anti-Calcitonin Gene-Related Peptide Therapy for Migraine and Other Chronic Headaches in Adolescents and Young Adults: A Retrospective Study in the USA
Abstract
:1. Main Manuscript
2. Methodology
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Column (Variables) | Summary |
---|---|
Age Group | n—out of 23 (%) |
12–15 Y | 9 (39.1) |
16–18 Y | 12 (52.2) |
>18 Y | 2 (8.7) |
Indication | |
Episodic Migraine (EM) | 3 (13) |
Chronic migraine (CM) | 18 (78.3) |
NDPH (CM) | 1 (4.3) |
Post-traumatic (CM, NDPH) | 1 (4.3) |
1st line preventive failures | |
1–2 meds | 13 (56.5) |
3–4 meds | 7 (30.4) |
>4 meds | 3 (13) |
History of concussion | |
Yes | 8 (34.8) |
No | 15 (65.2) |
Psychiatric conditions | |
Yes | 21 (91.3) |
No | 2 (8.7) |
Sleep disorder | |
Yes | 16 (69.6) |
No | 7 (30.4) |
Other neurological problems | |
Yes | 5 (21.7) |
No | 18 (78.3) |
Column (Variables) | Summary |
---|---|
Treatment | n—out of 23 (%) |
Anti-CGRP + Traditional | 9 (39.1) |
Anti-CGRP + OnabotulinumtoxinA | 3 (13) |
Anti-CGRP + OnabotulinumtoxinA + Traditional | 6 (26.1) |
Anti-CGRP alone | 5 (21.8) |
Months of use | |
<3 months | 3 (13) |
4–6 months | 2 (8.7) |
>6 months | 18 (78.3) |
Anti-CGRP therapy for rescue or prevention or both | |
Rescue | |
Prevention | 14 (60.9) |
Both | 9 (39.1) |
Column (Variables) | Summary |
---|---|
Response to rescue meds | n—out of 23 (%) |
Improved | 17 (73.9) |
No change | 6 (26.1) |
Reduction in rescue med use in a week | |
Yes (>50%) | 18 (78.3) |
No (<50%) | 5 (21.7) |
ER visit reduction | |
Yes | 13 (56.5) |
No | 10 (43.5) |
Duration of migraine reduced | |
A lot | 7 (30.4) |
Some | 14 (60.9) |
None | 2 (8.7) |
Intensity of migraine reduced | |
A lot | 9 (39.1) |
Some | 12 (52.2) |
None | 2 (8.7) |
Other bothersome symptom improvement | |
A lot | 9 (39.1) |
Some | 10 (43.5) |
None | 4 (17.4) |
Number of headache days reduction after 1 month | |
>50% | 9 (39.1) |
<50% | 10 (43.5) |
same | 4 (17.4) |
Number of headache days reduction after 3 months | |
>50% | 9 (39.1) |
<50% | 11 (47.8) |
Same | 3 (13) |
Adverse effects | |
Few | 1 (4.3) |
None | 22 (95.7) |
Discontinued for any reason | |
Yes | 7 (30.4) |
No | 16 (69.6) |
Patient satisfaction | |
Strongly | 16 (69.6) |
Doesn’t matter | 5 (21.7) |
No | 2 (8.7) |
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Bandatmakur, A.S.M.; Dave, P.; Kerr, M.; Brunick, C.; Wen, S.; Hansen, N. Effectiveness and Tolerability of Anti-Calcitonin Gene-Related Peptide Therapy for Migraine and Other Chronic Headaches in Adolescents and Young Adults: A Retrospective Study in the USA. Brain Sci. 2024, 14, 879. https://doi.org/10.3390/brainsci14090879
Bandatmakur ASM, Dave P, Kerr M, Brunick C, Wen S, Hansen N. Effectiveness and Tolerability of Anti-Calcitonin Gene-Related Peptide Therapy for Migraine and Other Chronic Headaches in Adolescents and Young Adults: A Retrospective Study in the USA. Brain Sciences. 2024; 14(9):879. https://doi.org/10.3390/brainsci14090879
Chicago/Turabian StyleBandatmakur, Anjaneya Shankar Madhav, Pooja Dave, Melissa Kerr, Colin Brunick, Sijin Wen, and Nicholas Hansen. 2024. "Effectiveness and Tolerability of Anti-Calcitonin Gene-Related Peptide Therapy for Migraine and Other Chronic Headaches in Adolescents and Young Adults: A Retrospective Study in the USA" Brain Sciences 14, no. 9: 879. https://doi.org/10.3390/brainsci14090879