Resolvin D5 Protects Female Hairless Mouse Skin from Pathological Alterations Caused by UVB Irradiation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. Animals
2.3. Experimental Protocol
2.4. Irradiation Protocol
2.5. Skin Edema
2.6. Total Antioxidant Capacity: FRAP and ABTS Assays
2.7. Quantification of Endogenous Antioxidant: Reduced Glutathione (GSH)
2.8. Catalase Assay
2.9. Superoxide Anion Production
2.10. Lipid Peroxidation Assay (LPO)
2.11. Cytokine Measurement by ELISA
2.12. Real-Time and Quantitative Polymerase Chain Reaction (RT-qPCR)
2.13. Skin Histologic Evaluation
2.14. Fluorescence Assay
2.15. Matrix Metalloproteinase (MMP)-9 Activity Measurement
2.16. Statistical Analysis
3. Results
3.1. Effect of Resolvin D5 (RvD5) against Skin Edema Caused by UVB Irradiation
3.2. RvD5 Inhibits UVB Irradiation-Induced Depletion of Skin Antioxidants
3.3. RvD5 Interferes with ROS Metabolization, Production and Generation of Lipid Peroxidation End-Products in UVB Irradiation
3.4. RvD5 Up-Regulates the mRNA Expression of Genes Involved in Skin Endogenous Antioxidant Response during UVB Irradiation Inflammation
3.5. RvD5 Inhibits UVB Irradiation-Induced Cytokine Production
3.6. RvD5 Reduces Mast Cell Counts in UVB Irradiation
3.7. RvD5 Treatment Inhibits Skin Recruitment of LysM+ Neutrophils/Macrophages in UVB Irradiation
3.8. RvD5 Inhibits MMP-9 Activity and Collagen Fibers Degradation in UVB Irradiation
3.9. RvD5 Inhibits UVB Irradiation-Induced Apoptosis of Keratinocytes
3.10. RvD5 Inhibits UVB Irradiation-Induced Epidermal Thickening
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Saito, P.; Pinto, I.C.; Rodrigues, C.C.A.; de Matos, R.L.N.; Vale, D.L.; Melo, C.P.B.; Fattori, V.; Saraiva-Santos, T.; Mendes-Pierotti, S.; Bertozzi, M.M.; et al. Resolvin D5 Protects Female Hairless Mouse Skin from Pathological Alterations Caused by UVB Irradiation. Antioxidants 2024, 13, 1008. https://doi.org/10.3390/antiox13081008
Saito P, Pinto IC, Rodrigues CCA, de Matos RLN, Vale DL, Melo CPB, Fattori V, Saraiva-Santos T, Mendes-Pierotti S, Bertozzi MM, et al. Resolvin D5 Protects Female Hairless Mouse Skin from Pathological Alterations Caused by UVB Irradiation. Antioxidants. 2024; 13(8):1008. https://doi.org/10.3390/antiox13081008
Chicago/Turabian StyleSaito, Priscila, Ingrid C. Pinto, Camilla C. A. Rodrigues, Ricardo L. N. de Matos, David L. Vale, Cristina P. B. Melo, Victor Fattori, Telma Saraiva-Santos, Soraia Mendes-Pierotti, Mariana M. Bertozzi, and et al. 2024. "Resolvin D5 Protects Female Hairless Mouse Skin from Pathological Alterations Caused by UVB Irradiation" Antioxidants 13, no. 8: 1008. https://doi.org/10.3390/antiox13081008