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Open AccessArticle
Ameliorative Effects of HT074-Inula and Paeonia Extract Mixture on Acute Reflux Esophagitis in Rats via Antioxidative Activity
by
Young-Sik Kim
Young-Sik Kim 1
,
Yeonjin Park
Yeonjin Park 2,
Yongbin Kim
Yongbin Kim 1,
Hyo-Eun Son
Hyo-Eun Son 1,
Jinhui Rhee
Jinhui Rhee 1,
Chang-Won Pyun
Chang-Won Pyun 3,
Chanoh Park
Chanoh Park 2 and
Hocheol Kim
Hocheol Kim 4,*
1
Department of Herbology, College of Korean Medicine, Woosuk University, Jeonju 54986, Republic of Korea
2
Department of Herbal Pharmacology, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
3
NEUMED R&BD Institute, NeuMed Inc., 88 Imun-ro, Dongdaemun-gu, Seoul 02440, Republic of Korea
4
Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
*
Author to whom correspondence should be addressed.
Antioxidants 2024, 13(8), 891; https://doi.org/10.3390/antiox13080891 (registering DOI)
Submission received: 12 June 2024
/
Revised: 16 July 2024
/
Accepted: 18 July 2024
/
Published: 23 July 2024
Abstract
HT074, a multiherbal mixture containing extracts from Inula britannica flowers and Paeonia lactiflora roots, is used in Korean medicine for gastric disorders. This study investigated the protective mechanisms of HT074 against acute reflux esophagitis (RE) in rats. Nitric oxide (NO) production and mRNA expression of antioxidant-related genes (Nrf2, HO-1, SOD, CAT, and GPx2) were evaluated in LPS-induced RAW 264.7 cells. Gastroesophageal reflux (GER) was induced in rats, followed by HT074 (100, 300 mg/kg) or ranitidine (50 mg/kg) administration. Esophageal damage and histological changes were assessed. Gastric pH and protein expression levels of Nrf2, HO-1, SOD, CAT, and GPx-1/2 were measured. HT074 pretreatment reduced NO production and increased the expression of HO-1, CAT, and GPx2 in LPS-induced RAW 264.7 cells. In GER-induced rats, HT074 significantly decreased esophageal lesions and increased the expression of HO-1, SOD, GPx-1/2, and Nrf2. HT074 did not affect gastric pH. These findings suggest that HT074 protects against GER-induced esophagitis by inhibiting NO production and enhancing antioxidant activity. Therefore, HT074 could be a promising therapeutic agent for GER disease.
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MDPI and ACS Style
Kim, Y.-S.; Park, Y.; Kim, Y.; Son, H.-E.; Rhee, J.; Pyun, C.-W.; Park, C.; Kim, H.
Ameliorative Effects of HT074-Inula and Paeonia Extract Mixture on Acute Reflux Esophagitis in Rats via Antioxidative Activity. Antioxidants 2024, 13, 891.
https://doi.org/10.3390/antiox13080891
AMA Style
Kim Y-S, Park Y, Kim Y, Son H-E, Rhee J, Pyun C-W, Park C, Kim H.
Ameliorative Effects of HT074-Inula and Paeonia Extract Mixture on Acute Reflux Esophagitis in Rats via Antioxidative Activity. Antioxidants. 2024; 13(8):891.
https://doi.org/10.3390/antiox13080891
Chicago/Turabian Style
Kim, Young-Sik, Yeonjin Park, Yongbin Kim, Hyo-Eun Son, Jinhui Rhee, Chang-Won Pyun, Chanoh Park, and Hocheol Kim.
2024. "Ameliorative Effects of HT074-Inula and Paeonia Extract Mixture on Acute Reflux Esophagitis in Rats via Antioxidative Activity" Antioxidants 13, no. 8: 891.
https://doi.org/10.3390/antiox13080891
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