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Antioxidants
Volume 14
Issue 2
10.3390/antiox14020126
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Review

Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways

by
Xiaofan Wei
†,
Laxman Manandhar
†,
Hyunsoo Kim
,
Arun Chhetri
,
Jaetaek Hwang
,
Gyuho Jang
,
Channy Park
and
Raekil Park
*
Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antioxidants 2025, 14(2), 126; https://doi.org/10.3390/antiox14020126
Submission received: 19 December 2024 / Revised: 20 January 2025 / Accepted: 21 January 2025 / Published: 23 January 2025
(This article belongs to the Special Issue Crosstalk between Autophagy and Oxidative Stress)
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Abstract

Peroxisomes generate reactive oxygen species (ROS) and also play a role in protecting cells from the damaging effects of such radicals. Dysfunctional peroxisomes are recognized by receptors and degraded by a selective type of macroautophagy called pexophagy. Oxidative stress is one of the signals that activates pexophagy through multiple signaling pathways. Conversely, impaired pexophagy results in the accumulation of damaged peroxisomes, which in turn leads to elevated ROS levels and oxidative stress, resulting as cellular dysfunction and the progression of diseases such as neurodegeneration, cancer, and metabolic disorders. This review explores the molecular mechanisms driving pexophagy and its regulation by oxidative stress with a particular focus on ROS. This highlights the role of peroxisomal proteins and ROS-mediated signaling pathways in regulating pexophagy. In addition, emerging evidence suggests that the dysregulation of pexophagy is closely linked to neurological disorders, underscoring its potential as a therapeutic target. Understanding the intricate crosstalk between pexophagy and oxidative stress provides new insights into the maintenance of cellular homeostasis and offers promising directions for addressing neurological disorders that are tightly associated with pexophagy and oxidative stress.
Keywords: peroxisome; pexophagy; autophagy; ROS peroxisome; pexophagy; autophagy; ROS

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MDPI and ACS Style

Wei, X.; Manandhar, L.; Kim, H.; Chhetri, A.; Hwang, J.; Jang, G.; Park, C.; Park, R. Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways. Antioxidants 2025, 14, 126. https://doi.org/10.3390/antiox14020126

AMA Style

Wei X, Manandhar L, Kim H, Chhetri A, Hwang J, Jang G, Park C, Park R. Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways. Antioxidants. 2025; 14(2):126. https://doi.org/10.3390/antiox14020126

Chicago/Turabian Style

Wei, Xiaofan, Laxman Manandhar, Hyunsoo Kim, Arun Chhetri, Jaetaek Hwang, Gyuho Jang, Channy Park, and Raekil Park. 2025. "Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways" Antioxidants 14, no. 2: 126. https://doi.org/10.3390/antiox14020126

APA Style

Wei, X., Manandhar, L., Kim, H., Chhetri, A., Hwang, J., Jang, G., Park, C., & Park, R. (2025). Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways. Antioxidants, 14(2), 126. https://doi.org/10.3390/antiox14020126

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