The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Assays
2.2.1. Antibody-Secreting Cell ELISpot Assay
2.2.2. Hemagglutination Inhibition (HAI) Assay
2.2.3. Statistical Analysis
3. Results
3.1. Demographics
3.2. Imprinting
3.2.1. Antibody Secreting Cells (ASC)
3.2.2. HAI Results
3.3. The Effects of Repeated Vaccination
3.3.1. ASC Results
3.3.2. HAI Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Influenza A(H1N1) | Influenza A(H3N2) | Influenza B (Victoria Lineage) | Influenza B (Yamagata Lineage) |
---|---|---|---|
A/Michigan/45/2015-like virus | A/Singapore/INFIMH-16-0019/2016-like virus | B/Colorado/06/2017-like virus | B/Phuket/3073/2013-like virus |
H3N2 Birth Cohort, Born between 1968 and 1977 (n = 10) | H1N1 Birth Cohort, Born between 1948 and 1957 (n = 10) | |
---|---|---|
Mean Age (SD) | 43.3 (2.3) | 65.5 (2.1) |
Mean Birth Year (range) | 1974 (1968–1977) | 1953 (1949–1955) |
Female sex—no. (%) | 3 (30) | 6 (60) |
Minimally Vaccinated—no. (%) | 5 (50) | 5 (50) |
Repeatedly Vaccinated—no. (%) | 5 (50) | 5 (50) |
Race or Ethnic Group—no. (%) | ||
White | 5 (50) | 6 (60) |
Black or African American | 1 (10) | 3 (30) |
Asian | 2 (20) | 0 (0) |
More than one race | 1 (10) | 0 (0) |
Choose not to report | 1 (10) | 1 (10) |
Hispanic | 0 (0) | 0 (0) |
Mean BMI (SD) | 26.53 (4.4) | 25.97 (5.2) |
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Sherman, A.C.; Lai, L.; Bower, M.; Natrajan, M.S.; Huerta, C.; Karmali, V.; Kleinhenz, J.; Xu, Y.; Rouphael, N.; Mulligan, M.J. The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination. Vaccines 2020, 8, 663. https://doi.org/10.3390/vaccines8040663
Sherman AC, Lai L, Bower M, Natrajan MS, Huerta C, Karmali V, Kleinhenz J, Xu Y, Rouphael N, Mulligan MJ. The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination. Vaccines. 2020; 8(4):663. https://doi.org/10.3390/vaccines8040663
Chicago/Turabian StyleSherman, Amy C., Lilin Lai, Mary Bower, Muktha S. Natrajan, Christopher Huerta, Vinit Karmali, Jennifer Kleinhenz, Yongxian Xu, Nadine Rouphael, and Mark J. Mulligan. 2020. "The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination" Vaccines 8, no. 4: 663. https://doi.org/10.3390/vaccines8040663