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Article
Peer-Review Record

Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder

J. Clin. Med. 2021, 10(22), 5414; https://doi.org/10.3390/jcm10225414
by Sooyeoun You 1,†, Kyoung Sook Won 2,†, Keun Tae Kim 1, Hyang Woon Lee 3,* and Yong Won Cho 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
J. Clin. Med. 2021, 10(22), 5414; https://doi.org/10.3390/jcm10225414
Submission received: 29 October 2021 / Revised: 15 November 2021 / Accepted: 16 November 2021 / Published: 19 November 2021
(This article belongs to the Special Issue Sleep Disorders: Latest Advances and Prospects)

Round 1

Reviewer 1 Report

This paper is very important. cardiac MIBG is lower even in patients with isolated RBD.

1) How was the relationship between the other autonomic parameters and MIBC findings?

2) Could you show MOCA (cognitive function measure) or olfactory function of the subject patients?

3) Some iRBD patients with normal MIBG finding develop to multiple system atrophy but not to PD. Do you have some comment about this?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

We have to congratulate the authors for a well written manuscript.

We agree with authors the main limitations of this study the small sample studied,and the lack of matching between control and cases.

I miss the posibiity to include a Dopamine Dat Scan to exclude silence prevalence PD  in cases or controls.

We believe this manuscript deserved to be published as it is original in the correlation of both tests.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

I feel that this paper is well written.

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