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Article

Attenuation Imaging with Ultrasound as a Novel Evaluation Method for Liver Steatosis

by
Po-Ke Hsu
1,2,
Li-Sha Wu
3,
Hsu-Heng Yen
1,
Hsiu Ping Huang
1,
Yang-Yuan Chen
1,
Pei-Yuan Su
1 and
Wei-Wen Su
1,*
1
Department of Gastroenterology, Changhua Christian Hospital, Changhua 50006, Taiwan
2
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
3
Department of Ultrasound, Changhua Christian Hospital, Changhua 50006, Taiwan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(5), 965; https://doi.org/10.3390/jcm10050965
Submission received: 24 January 2021 / Revised: 18 February 2021 / Accepted: 18 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue Challenges in Nonalcoholic Steatohepatitis)
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Abstract

In recent years, ultrasound attenuation imaging (ATI) has emerged as a new method to detect liver steatosis. However, thus far, no studies have confirmed the clinical utility of this technology. Using a retrospective database analysis of 28 patients with chronic liver disease who underwent ultrasound liver biopsy and ATI, we compared the presence and degree of steatosis measured by ATI with the results obtained through liver biopsy. The area under the receiver operating characteristic curve (AUROC) of the ATI for differentiating between normal and hepatic steatosis was 0.97 (95% confidence interval: 0.83–1.00). The AUROC of the ATI was 0.99 (95% confidence interval: 0.86–1.00) in grade ≥2 liver steatosis and 0.97 (95% confidence interval: 0.82–1.00) in grade 3. ATI showed good consistency and accuracy for the steatosis grading of liver biopsy. Therefore, ATI represents a novel diagnostic measurement to support the diagnosis of liver steatosis in non-invasive clinical practice.
Keywords: attenuation imaging; ultrasound; liver steatosis attenuation imaging; ultrasound; liver steatosis

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MDPI and ACS Style

Hsu, P.-K.; Wu, L.-S.; Yen, H.-H.; Huang, H.P.; Chen, Y.-Y.; Su, P.-Y.; Su, W.-W. Attenuation Imaging with Ultrasound as a Novel Evaluation Method for Liver Steatosis. J. Clin. Med. 2021, 10, 965. https://doi.org/10.3390/jcm10050965

AMA Style

Hsu P-K, Wu L-S, Yen H-H, Huang HP, Chen Y-Y, Su P-Y, Su W-W. Attenuation Imaging with Ultrasound as a Novel Evaluation Method for Liver Steatosis. Journal of Clinical Medicine. 2021; 10(5):965. https://doi.org/10.3390/jcm10050965

Chicago/Turabian Style

Hsu, Po-Ke, Li-Sha Wu, Hsu-Heng Yen, Hsiu Ping Huang, Yang-Yuan Chen, Pei-Yuan Su, and Wei-Wen Su. 2021. "Attenuation Imaging with Ultrasound as a Novel Evaluation Method for Liver Steatosis" Journal of Clinical Medicine 10, no. 5: 965. https://doi.org/10.3390/jcm10050965

APA Style

Hsu, P.-K., Wu, L.-S., Yen, H.-H., Huang, H. P., Chen, Y.-Y., Su, P.-Y., & Su, W.-W. (2021). Attenuation Imaging with Ultrasound as a Novel Evaluation Method for Liver Steatosis. Journal of Clinical Medicine, 10(5), 965. https://doi.org/10.3390/jcm10050965

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