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10.3390/jcm12134351
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Review

Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications

by
Simone La Padula
1,2,*,
Martina Ponzo
1,
Mariagiovanna Lombardi
1,
Vincenzo Iazzetta
1,
Concetta Errico
1,
Gianmarco Polverino
1,
Francesca Russo
1,
Luca D’Andrea
1,
Barbara Hersant
2,
Jean Paul Meningaud
2,
Giovanni Salzano
3 and
Rosita Pensato
1
1
Department of Plastic and Reconstructive Surgery, Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy
2
Department of Plastic, Reconstructive and Maxillo-Facial Surgery, Henri Mondor Hospital, University Paris, XII, 51 Avenue du Maréchal de Lattre de Tassigny, 94000 Créteil, France
3
Maxillofacial Surgery Unit, Federico II University of Naples, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(13), 4351; https://doi.org/10.3390/jcm12134351
Submission received: 11 April 2023 / Revised: 19 June 2023 / Accepted: 25 June 2023 / Published: 28 June 2023
(This article belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
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Abstract

Nanofat is a relatively novel technique in fat grafting that has gained significant interest in the fields of regenerative medicine, aesthetic and translational research. It involves the extraction of autologous fat from a patient, which is then transformed into “nanofat”, consisting of small fat particles with a diameter of less than 0.1 mm and containing high concentrations of stem cells and growth factors. This article focuses on the use of nanofat in facial rejuvenation and its potential for lipomodelling. Fat tissue is a “stem cell depot” and nanofat contains many stem cells that can differentiate into various cell types. The Lipogem technology, developed in 2013, enables the isolation of nanofat with an intact perivascular structure, utilizing the high concentration of mesenchymal stromal cells near the pericytes of the adipose vascular system. Nowadays nanofat is used primarily for cosmetic purposes particularly in rejuvenating and improving the appearance of the skin, especially the face. Indeed, it has wide applicability; it can be used to treat fine lines, wrinkles, acne scars, sun-damaged skin, scar repair, and as an alopecia treatment. However, further studies are needed to assess the long-term efficacy and safety of this technique. In conclusion, nanofat is a safe and minimally invasive option for tissue regeneration with considerable therapeutic potential. This study reviews the application and effects of nanofat in regenerative medicine and facial cosmetic surgery.
Keywords: nanofat; stromal vascular tissue; regenerative medicine; fat graft; facial rejuvenation; lipomodelling; a review nanofat; stromal vascular tissue; regenerative medicine; fat graft; facial rejuvenation; lipomodelling; a review

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MDPI and ACS Style

La Padula, S.; Ponzo, M.; Lombardi, M.; Iazzetta, V.; Errico, C.; Polverino, G.; Russo, F.; D’Andrea, L.; Hersant, B.; Meningaud, J.P.; et al. Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications. J. Clin. Med. 2023, 12, 4351. https://doi.org/10.3390/jcm12134351

AMA Style

La Padula S, Ponzo M, Lombardi M, Iazzetta V, Errico C, Polverino G, Russo F, D’Andrea L, Hersant B, Meningaud JP, et al. Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications. Journal of Clinical Medicine. 2023; 12(13):4351. https://doi.org/10.3390/jcm12134351

Chicago/Turabian Style

La Padula, Simone, Martina Ponzo, Mariagiovanna Lombardi, Vincenzo Iazzetta, Concetta Errico, Gianmarco Polverino, Francesca Russo, Luca D’Andrea, Barbara Hersant, Jean Paul Meningaud, and et al. 2023. "Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications" Journal of Clinical Medicine 12, no. 13: 4351. https://doi.org/10.3390/jcm12134351

APA Style

La Padula, S., Ponzo, M., Lombardi, M., Iazzetta, V., Errico, C., Polverino, G., Russo, F., D’Andrea, L., Hersant, B., Meningaud, J. P., Salzano, G., & Pensato, R. (2023). Nanofat in Plastic Reconstructive, Regenerative, and Aesthetic Surgery: A Review of Advancements in Face-Focused Applications. Journal of Clinical Medicine, 12(13), 4351. https://doi.org/10.3390/jcm12134351

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