Next Article in Journal
Prediction of Postoperative Pulmonary Edema Risk Using Machine Learning
Previous Article in Journal
Precision Medicine and the future of Cardiovascular Diseases: A Clinically Oriented Comprehensive Review
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 12
Issue 5
10.3390/jcm12051803
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Communication

Expression of pH-Sensitive GPCRs in Peritoneal Carcinomatosis of Colorectal Cancer—First Results

by
Philipp von Breitenbuch
1,
Bernadett Kurz
2,
Susanne Wallner
2,
Florian Zeman
3,
Christoph Brochhausen
4,
Hans-Jürgen Schlitt
5 and
Stephan Schreml
2,*
1
Department of Surgery, Elblandklinikum Radebeul, 01445 Radebeul, Germany
2
Department of Dermatology, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
3
Center for Clinical Studies, University Medical Center Regensburg, 93053 Regensburg, Germany
4
Institute of Pathology, University Medical Center Regensburg, 93053 Regensburg, Germany
5
Department of Surgery, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(5), 1803; https://doi.org/10.3390/jcm12051803
Submission received: 27 December 2022 / Revised: 6 February 2023 / Accepted: 20 February 2023 / Published: 23 February 2023
(This article belongs to the Topic The Tumor Microenvironment and Immune Checkpoint: Implications for Current and Emergent Immunotherapies)
Browse Figure
Review Reports Versions Notes

Abstract

Solid tumors have an altered metabolism with a so-called inside-out pH gradient (decreased pHe < increased pHi). This also signals back to tumor cells via proton-sensitive ion channels or G protein-coupled receptors (pH-GPCRs) to alter migration and proliferation. Nothing, however, is known about the expression of pH-GPCRs in the rare form of peritoneal carcinomatosis. Paraffin-embedded tissue samples of a series of 10 patients with peritoneal carcinomatosis of colorectal (including appendix) origin were used for immunohistochemistry to study the expression of GPR4, GPR65, GPR68, GPR132, and GPR151. GPR4 was just expressed weakly in 30% of samples and expression was significantly reduced as compared to GPR56, GPR132, and GPR151. Furthermore, GPR68 was only expressed in 60% of tumors and showed significantly reduced expression as compared to GPR65 and GPR151. This is the first study on pH-GPCRs in peritoneal carcinomatosis, which shows lower expression of GPR4 and GPR68 as compared to other pH-GPCRs in this type of cancer. It may give rise to future therapies targeting either the TME or these GPCRs directly.
Keywords: colorectal; peritoneal carcinomatosis; tumor microenvironment colorectal; peritoneal carcinomatosis; tumor microenvironment

Share and Cite

MDPI and ACS Style

von Breitenbuch, P.; Kurz, B.; Wallner, S.; Zeman, F.; Brochhausen, C.; Schlitt, H.-J.; Schreml, S. Expression of pH-Sensitive GPCRs in Peritoneal Carcinomatosis of Colorectal Cancer—First Results. J. Clin. Med. 2023, 12, 1803. https://doi.org/10.3390/jcm12051803

AMA Style

von Breitenbuch P, Kurz B, Wallner S, Zeman F, Brochhausen C, Schlitt H-J, Schreml S. Expression of pH-Sensitive GPCRs in Peritoneal Carcinomatosis of Colorectal Cancer—First Results. Journal of Clinical Medicine. 2023; 12(5):1803. https://doi.org/10.3390/jcm12051803

Chicago/Turabian Style

von Breitenbuch, Philipp, Bernadett Kurz, Susanne Wallner, Florian Zeman, Christoph Brochhausen, Hans-Jürgen Schlitt, and Stephan Schreml. 2023. "Expression of pH-Sensitive GPCRs in Peritoneal Carcinomatosis of Colorectal Cancer—First Results" Journal of Clinical Medicine 12, no. 5: 1803. https://doi.org/10.3390/jcm12051803

APA Style

von Breitenbuch, P., Kurz, B., Wallner, S., Zeman, F., Brochhausen, C., Schlitt, H.-J., & Schreml, S. (2023). Expression of pH-Sensitive GPCRs in Peritoneal Carcinomatosis of Colorectal Cancer—First Results. Journal of Clinical Medicine, 12(5), 1803. https://doi.org/10.3390/jcm12051803

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop