This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessArticle
Prognostic Factors of Pulmonary Metastasectomy for Oligometastatic Hepatocellular Carcinoma Spread to the Lungs
by
Bohyun Kim
Bohyun Kim 1,
Mi Hyoung Moon
Mi Hyoung Moon 2,* and
Seok Whan Moon
Seok Whan Moon 2
1
Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
2
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(14), 4241; https://doi.org/10.3390/jcm13144241 (registering DOI)
Submission received: 1 July 2024
/
Revised: 17 July 2024
/
Accepted: 19 July 2024
/
Published: 20 July 2024
(This article belongs to the Section
Oncology)
Abstract
Background/Objectives: Pulmonary metastasis is the most prevalent type of extrahepatic hepatocellular carcinoma (HCC) metastasis. International guidelines recommend systemic treatment for patients with HCC having pulmonary metastases. However, the role of pulmonary metastasectomy (PM) remains relatively unexplored. Therefore, we assessed the survival outcomes and the factors influencing them in patients who underwent PM for metastatic HCC. Methods: Clinical data were collected from patients with HCC who underwent PM for metastasis at a single tertiary center between January 2004 and December 2022. Recurrence-free survival and overall survival were assessed using Kaplan–Meier curves. The Cox proportional hazards model was used to identify factors associated with survival outcomes. Results: Overall, 63 patients underwent PM with a median follow-up time of 84.0 months. The cumulative survival rates after the initial PM at 1, 2, and 5 years were 79.1%, 63.9%, and 35.6%, respectively. In multivariate analysis, early intrathoracic recurrence < 6 months, number and size of metastases, resection margin status, and PM bilaterality were significantly associated with overall survival. A larger size of the primary HCC, increased number of repeated PM, and frequent lobectomy were more common in patients with early (<6 months) recurrence after PM than in those without early recurrence. Conclusions: PM in patients with metastatic HCC may provide acceptable survival outcomes for those with smaller, unilateral lung metastases that can be resected with generous surgical margins. However, early recurrence with reduced overall survival is likely in patients with a larger-size initial HCC after prior PM and lobectomy.
Share and Cite
MDPI and ACS Style
Kim, B.; Moon, M.H.; Moon, S.W.
Prognostic Factors of Pulmonary Metastasectomy for Oligometastatic Hepatocellular Carcinoma Spread to the Lungs. J. Clin. Med. 2024, 13, 4241.
https://doi.org/10.3390/jcm13144241
AMA Style
Kim B, Moon MH, Moon SW.
Prognostic Factors of Pulmonary Metastasectomy for Oligometastatic Hepatocellular Carcinoma Spread to the Lungs. Journal of Clinical Medicine. 2024; 13(14):4241.
https://doi.org/10.3390/jcm13144241
Chicago/Turabian Style
Kim, Bohyun, Mi Hyoung Moon, and Seok Whan Moon.
2024. "Prognostic Factors of Pulmonary Metastasectomy for Oligometastatic Hepatocellular Carcinoma Spread to the Lungs" Journal of Clinical Medicine 13, no. 14: 4241.
https://doi.org/10.3390/jcm13144241
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.