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Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay
by
Konstantinos Arvanitakis
Konstantinos Arvanitakis 1,2,
Elena Chatzikalil
Elena Chatzikalil 3,
Georgios Kalopitas
Georgios Kalopitas 1,2,
Dimitrios Patoulias
Dimitrios Patoulias 4,
Djordje S. Popovic
Djordje S. Popovic 5,6,
Symeon Metallidis
Symeon Metallidis 1,7,
Kalliopi Kotsa
Kalliopi Kotsa 7,
Georgios Germanidis
Georgios Germanidis 1,2 and
Theocharis Koufakis
Theocharis Koufakis 4,*
1
Division of Gastroenterology and Hepatology, First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636 Thessaloniki, Greece
2
Basic and Translational Research Unit, Special Unit for Biomedical Research and Education, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece
3
Athens Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
4
Second Propaedeutic Department of Internal Medicine, Hippokration General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
5
Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Vojvodina, 21000 Novi Sad, Serbia
6
Medical Faculty, University of Novi Sad, 21000 Novi Sad, Serbia
7
Division of Endocrinology, First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(14), 4243; https://doi.org/10.3390/jcm13144243 (registering DOI)
Submission received: 8 June 2024
/
Revised: 17 July 2024
/
Accepted: 18 July 2024
/
Published: 20 July 2024
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary syndrome (PCOS) are prevalent conditions that have been correlated with infertility through overlapped pathophysiological mechanisms. MASLD is associated with metabolic syndrome and is considered among the major causes of chronic liver disease, while PCOS, which is characterized by ovulatory dysfunction and hyperandrogenism, is one of the leading causes of female infertility. The pathophysiological links between PCOS and MASLD have not yet been fully elucidated, with insulin resistance, hyperandrogenemia, obesity, and dyslipidemia being among the key pathways that contribute to liver lipid accumulation, inflammation, and fibrosis, aggravating liver dysfunction. On the other hand, MASLD exacerbates insulin resistance and metabolic dysregulation in women with PCOS, creating a vicious cycle of disease progression. Understanding the intricate relationship between MASLD and PCOS is crucial to improving clinical management, while collaborative efforts between different medical specialties are essential to optimize fertility and liver health outcomes in individuals with MASLD and PCOS. In this review, we summarize the complex interplay between MASLD and PCOS, highlighting the importance of increasing clinical attention to the prevention, diagnosis, and treatment of both entities.
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MDPI and ACS Style
Arvanitakis, K.; Chatzikalil, E.; Kalopitas, G.; Patoulias, D.; Popovic, D.S.; Metallidis, S.; Kotsa, K.; Germanidis, G.; Koufakis, T.
Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay. J. Clin. Med. 2024, 13, 4243.
https://doi.org/10.3390/jcm13144243
AMA Style
Arvanitakis K, Chatzikalil E, Kalopitas G, Patoulias D, Popovic DS, Metallidis S, Kotsa K, Germanidis G, Koufakis T.
Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay. Journal of Clinical Medicine. 2024; 13(14):4243.
https://doi.org/10.3390/jcm13144243
Chicago/Turabian Style
Arvanitakis, Konstantinos, Elena Chatzikalil, Georgios Kalopitas, Dimitrios Patoulias, Djordje S. Popovic, Symeon Metallidis, Kalliopi Kotsa, Georgios Germanidis, and Theocharis Koufakis.
2024. "Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay" Journal of Clinical Medicine 13, no. 14: 4243.
https://doi.org/10.3390/jcm13144243
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