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Open AccessArticle
Quantitative Magnetic Resonance Cholangiopancreatography Scoring and Its Predictive Value for Outcomes in Adults with Primary Sclerosing Cholangitis
by
Matei Mandea
Matei Mandea 1,2,3,†
,
Speranta Maria Iacob
Speranta Maria Iacob 1,2,3,†
,
Mugur Cristian Grasu
Mugur Cristian Grasu 2,4,*
,
Cristian Anghel
Cristian Anghel 2,4
,
Razvan Andrei Iacob
Razvan Andrei Iacob 1,2,3
,
Mihaela Corina Ghioca
Mihaela Corina Ghioca 1,2,3,
Cristian Gheorghe
Cristian Gheorghe 1,2,3 and
Liliana Simona Gheorghe
Liliana Simona Gheorghe 1,2,3
1
Department of Internal Medicine, Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy Carol Davila, 050474 Bucharest, Romania
2
Department of Radiology, Medical Imaging and Interventional Radiology I, University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, Romania
3
Digestive Diseases and Liver Transplant Center, Fundeni Clinical Institute, 022328 Bucharest, Romania
4
Laboratory of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2024, 13(15), 4548; https://doi.org/10.3390/jcm13154548 (registering DOI)
Submission received: 26 May 2024
/
Revised: 13 July 2024
/
Accepted: 1 August 2024
/
Published: 3 August 2024
Abstract
Background: Primary sclerosing cholangitis (PSC) is an immune-mediated disease that has an unfavorable prognosis and needs a liver transplant (LT). The aim of this paper was to show the usefulness of the Majoie classification on magnetic resonance cholangiopancreatography (MRCP) images in assessing the prognosis in adult patients with PSC. Methods: Our work presents a retrospective monocentric study performed on 64 adult patients with PSC of the large bile ducts. Two radiologists evaluated the MRCP of diagnosis and calculated MRCP scores using the Majoie classification. Liver-related outcome (LT or liver-related death) was marked as a primary endpoint. Results: Univariate analysis showed that patients with more severe lesions (sum score of intrahepatic and extrahepatic ducts > 3) had a lower age at diagnosis, of 37.2 years, complicated with liver cirrhosis (53.1% of patients) and recurrent cholangitis (28.1%) p < 0.05, without significant differences in mortality, association with IBD or LT. Concordance analysis between MRCP prognostic scores and progression to a PSC-related event showed a moderate relationship (c-statistic 0.662), and a good AUROC was observed for the UKPSC score (0.893) and the MRS (0.936). Conclusions: In the study, we observed a good correlation between the imaging scores based on the Majoie classification and the evolution of the patients. These scores were outperformed by the UKPSC, MRS, and PREsTo clinical models. Their utility was best in predicting recurrent cholangitis.
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MDPI and ACS Style
Mandea, M.; Iacob, S.M.; Grasu, M.C.; Anghel, C.; Iacob, R.A.; Ghioca, M.C.; Gheorghe, C.; Gheorghe, L.S.
Quantitative Magnetic Resonance Cholangiopancreatography Scoring and Its Predictive Value for Outcomes in Adults with Primary Sclerosing Cholangitis. J. Clin. Med. 2024, 13, 4548.
https://doi.org/10.3390/jcm13154548
AMA Style
Mandea M, Iacob SM, Grasu MC, Anghel C, Iacob RA, Ghioca MC, Gheorghe C, Gheorghe LS.
Quantitative Magnetic Resonance Cholangiopancreatography Scoring and Its Predictive Value for Outcomes in Adults with Primary Sclerosing Cholangitis. Journal of Clinical Medicine. 2024; 13(15):4548.
https://doi.org/10.3390/jcm13154548
Chicago/Turabian Style
Mandea, Matei, Speranta Maria Iacob, Mugur Cristian Grasu, Cristian Anghel, Razvan Andrei Iacob, Mihaela Corina Ghioca, Cristian Gheorghe, and Liliana Simona Gheorghe.
2024. "Quantitative Magnetic Resonance Cholangiopancreatography Scoring and Its Predictive Value for Outcomes in Adults with Primary Sclerosing Cholangitis" Journal of Clinical Medicine 13, no. 15: 4548.
https://doi.org/10.3390/jcm13154548
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