Bacteria, Fungi, and Scalp Psoriasis: Understanding the Role of the Microbiome in Disease Severity
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Subjects and Sample Collection
2.2. Definition of PASI and Scalp PASI
2.3. DNA Extraction
2.4. Fungal Identification by Internal Transcribed Spacer (ITS) Sequencing Analysis
2.5. Bacterial Identification
2.6. Prediction of Functional Profiling
2.7. Statistical Analysis
3. Results
3.1. Demographics of the Patients with Scalp Psoriasis
3.2. Biodiversity According to the Severity of Scalp Psoriasis
3.2.1. Fungal Biodiversity According to Scalp Psoriasis Severity
3.2.2. Bacterial Biodiversity According to Scalp Psoriasis Severity
3.3. Taxonomical Compositions of Each Severity Group
3.3.1. Fungal Taxonomical Compositions of Each Severity Group
3.3.2. Bacterial Taxonomical Compositions of Each Severity Group
3.3.3. Functional Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total (n = 11) | Mild Scalp Psoriasis (n = 2) | Moderate Scalp Psoriasis (n = 4) | Severe Scalp Psoriasis (n = 5) | |
---|---|---|---|---|
Age, years (mean ± SD *) | 41.36 ± 19.77 | 39.25 ± 23.44 | 41.6 ± 20.82 | 42.13 ± 19.61 |
Gender (Male/Female) | 9:2 | 2:0 | 4:0 | 3:2 |
Scalp PASI (mean ± SD *) | 1.87 ± 0.93 | 0.55 ± 0.35 | 1.4 ± 0.28 | 2.62 ± 0.54 |
PASI (mean ± SD *) | 7.53 ± 6.29 | 1.95 ± 0.07 | 8.13 ± 8.35 | 9 ± 5.47 |
Current treatment | ||||
Biologics | 7 | 2 | 3 | 2 |
Cyclosporine | 3 | 0 | 1 | 2 |
Topical steroid/calcipotriol | 1 | 0 | 0 | 1 |
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Choi, J.-Y.; Kim, H.; Min, K.-H.; Song, W.-H.; Yu, D.-S.; Lee, M.; Lee, Y.-B. Bacteria, Fungi, and Scalp Psoriasis: Understanding the Role of the Microbiome in Disease Severity. J. Clin. Med. 2024, 13, 4846. https://doi.org/10.3390/jcm13164846
Choi J-Y, Kim H, Min K-H, Song W-H, Yu D-S, Lee M, Lee Y-B. Bacteria, Fungi, and Scalp Psoriasis: Understanding the Role of the Microbiome in Disease Severity. Journal of Clinical Medicine. 2024; 13(16):4846. https://doi.org/10.3390/jcm13164846
Chicago/Turabian StyleChoi, Jin-Young, Hyunseong Kim, Kyung-Hyun Min, Woo-Hyun Song, Dong-Soo Yu, Minho Lee, and Young-Bok Lee. 2024. "Bacteria, Fungi, and Scalp Psoriasis: Understanding the Role of the Microbiome in Disease Severity" Journal of Clinical Medicine 13, no. 16: 4846. https://doi.org/10.3390/jcm13164846