Neurological Validation of ASD Diagnostic Criteria Using Frontal Alpha and Theta Asymmetry
Abstract
:1. Introduction
1.1. Autism Spectrum Disorder
1.2. EEG, FAA, and ASD
1.3. EEG and ASD Symptomatology
1.4. Study Aims
2. Materials and Methods
2.1. Participants
2.2. Instruments
2.3. EEG
2.4. Procedure
2.4.1. Data Acquisition and Pre-Processing
2.4.2. EEG Signal Processing
2.5. Statistical Analysis
3. Results
3.1. Data
3.2. Asymmetry Data
3.3. Associations between ADOS-2 Scores and Asymmetry Data
4. Discussion
4.1. Major Findings
4.2. Clinical Implications
4.3. Limitations and Future Research
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ADOS-2: Social Affect | |||||||||
---|---|---|---|---|---|---|---|---|---|
Reporting Events | Conversation | Descriptive Gestures | Eye Contact | Facial Expressions | Shared Enjoyment | Social Overtures | Social Response | Reciprocal Social Comm. | Quality of Rapport |
1.80 (0.40) | 1.71 (0.46) | 1.95 (0.22) | 1.80 (0.61) | 1.61 (0.49) | 1.56 (0.50) | 1.66 (0.48) | 1.49 (0.55) | 1.88 (0.33) | 1.59 (0.55) |
ADOS-2: Restricted and Repetitive Behavior | |||||||||
Stereotypic words | Sensory interest | Hand, finger mannerisms | Excessive interest/Repetitive behaviors | ||||||
0.85 (0.65) | 0.29 (0.12) | 0.51 (0.23) | 0.39 (0.32) |
Site | FP1 | FP2 | F3 | F4 | F7 | F8 | FT7 | FT8 | FC3 | FC4 |
---|---|---|---|---|---|---|---|---|---|---|
Alpha | 1.56 (0.96) | 1.56 (1.01) | 1.45 (0.91) | 1.51 (0.88) | 1.51 (0.92) | 1.55 (0.91) | 1.43 (0.83) | 1.47 (0.87) | 1.55 (1.23) | 1.54 (0.95) |
Theta | 2.22 (1.60) | 2.27 (1.76) | 1.77 (1.20) | 1.88 (1.26) | 1.96 (1.38) | 1.97 (1.31) | 1.81 (1.10) | 1.72 (1.16) | 1.41 (1.03) | 1.47 (1.00) |
ADOS-2/EEG | SA: Reporting Events | SA: Conversation | SA: Eye Contact | SA: Shared Enjoyment | SA: Social Overtures | SA: Reciprocal Social | RRB: Hand, Finger Mannerisms | RRB: Excessive Interest/Repetitive Behaviors | Totals |
---|---|---|---|---|---|---|---|---|---|
FP2–FP1: theta | 0 | ||||||||
FP2–FP1: alpha | 0.363 | 1 | |||||||
F8–F7: theta | 0.311 | 1 | |||||||
F8–F7: alpha | 0.385 | 0.333 | 0.345 | 0.608 | 4 | ||||
F4–F3: theta | 0.356 | 1 | |||||||
F4–F3: alpha | 0.421 | 0.327 | 0.346 | 3 | |||||
FT8–FT7: theta | 0.335 | −0.329 | 2 | ||||||
FT8–FT7: alpha | 0.417 | 1 | |||||||
FC4–FC3: theta | 0.426 | 0.415 | 0.335 | 3 | |||||
FC4–FC3: alpha | 0.456 | 1 |
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Bitsika, V.; Sharpley, C.F.; Evans, I.D.; Vessey, K.A. Neurological Validation of ASD Diagnostic Criteria Using Frontal Alpha and Theta Asymmetry. J. Clin. Med. 2024, 13, 4876. https://doi.org/10.3390/jcm13164876
Bitsika V, Sharpley CF, Evans ID, Vessey KA. Neurological Validation of ASD Diagnostic Criteria Using Frontal Alpha and Theta Asymmetry. Journal of Clinical Medicine. 2024; 13(16):4876. https://doi.org/10.3390/jcm13164876
Chicago/Turabian StyleBitsika, Vicki, Christopher F. Sharpley, Ian D. Evans, and Kirstan A. Vessey. 2024. "Neurological Validation of ASD Diagnostic Criteria Using Frontal Alpha and Theta Asymmetry" Journal of Clinical Medicine 13, no. 16: 4876. https://doi.org/10.3390/jcm13164876