A Narrative Review of the Association between Dental Abnormalities and Chemotherapy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Inclusion Criteria
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- Articles that could be viewed in their entirety;
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- Articles with their full text in English;
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- Clinical investigations that were not case reports or reviews;
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- Studies that investigated the prevalence of dental abnormalities using panoramic radiography.
2.3. Exclusion Criteria
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- Articles that were not suitable for the objective of this review or used the wrong study design;
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- Studies that investigated the prevalence of dental abnormalities using cone beam computed tomography imaging;
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- Articles about congenital diseases such as syndromes or those with a limited number of subjects or insufficient data; however, a control group was only included when the prevalence of a healthy group was described.
2.4. Study Selection
2.5. Data Extraction
2.6. Quality Assessment
3. Results
4. Discussion
4.1. Dental Anomalies
4.2. Tooth Agenesis and Hypodontia
4.3. Microdonts
4.4. Dental Abnormalities in the General Population
4.5. Dental Abnormalities in Patients Who Have Undergone Cancer Treatment or Chemotherapy
4.6. Oral Care during Cancer Treatment
4.7. Oral Care after Cancer Treatment
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Author | Quality of Evidence | Subject | Mean Age [Years (Range)] | Dental Abnormalities (%) | Tooth Agenesis or Hypodontia (%) | Microdonts (%) |
---|---|---|---|---|---|---|
Lexner MO, 2007 [15] | Low | Female controls (n = 73) | 29 * (15–58) | - | 9 * | - |
Chung CJ, 2008 [16] | High | Patients with mixed to permanent dentition (n = 1622) | - | - | 11.2 | - |
Paulsson L, 2008 [17] | Low | Control group with full-term normal birth weight (n = 41) | 9.5 | - | 4.9 | - |
Abe R, 2010 [18] | Low | Control group (n = 32) | 8.8 | - | 6.3 | - |
Ajami BA, 2010 [19] | Moderate | Children aged 9–14 years (n = 600) | 10.6 | - | 9.0 | - |
Gupta SK, 2011 [20] | Moderate | Indian subjects (n = 1123) | - | 34.3 | 4.5 | 2.6 |
Kim YH, 2011 [21] | High | Korean orthodontic patients (n = 3055) | 15.1 (9–30) | - | 11.3 | - |
Lauritano D, 2012 [22] | Low | Control group (n = 52) | 11.0 | - | 3.8 | 7.6 |
Mukhopadhyay S, 2014 [23] | Low | Bengali-speaking nursery children (n = 2757) | - (4–6) | 1.8 | 0.5 | - |
Fekonja A, 2015 [24] | Moderate | Caucasian subjects born in 1966, 1976, 1986, and 1996 (n = 2546) | - | 11.5 | 6.9 | - |
Medina AC, 2016 [25] | Low | Healthy Venezuelan children (n = 1188) | - (5–12) | - | 5.6 | - |
Yassin SM, 2016 [26] | Low | Saudi children (n = 1252) | - (5–12) | 25.4 | 9.7 | 2.6 |
Fekonja A, 2017 [27] | Moderate | Patients treated at the orthodontic department (n = 473) | 14.2 | 16.7 | 7.2 | 2.5 |
Gracco ALT, 2017 [28] | High | Caucasian orthodontic patients (n = 4006) | - (9–16) | - | 9.0 | - |
Park MK, 2017 [29] | Moderate | Patients with no systemic diseases (n = 4611) | - (6.0–12.9) | - | 9.1 | - |
Dallel I, 2018 [30] | Moderate | Orthodontic patients (n = 1000) | 20 * | - | 7.8 | - |
Fernandez CCA, 2018 [31] | Moderate | Orthodontic records of patients (n = 1047) | 16.4 | 15.7 | 9.7 | 5.3 |
Septer S, 2018 [32] | Low | Control group (n = 46) | 13.7 | 54.3 | 6.5 | - |
Kılınç G, 2019 [33] | Low | Healthy siblings of pediatric patients treated for cancer (n = 93) | 10.6 (8–16) | 9.7 | 0.0 | 0.0 |
MacDonald D, 2020 [34] | High | New patient examination (n = 6252) | - (7–90) | 32.1 | 1.5 | - |
Wagner VP, 2020 [35] | Moderate | Patients who received panoramic examination 2014–2016 (n = 512) | 8.8 (6–12) | 61.3 | 29.3 | 0.6 |
Jankowski T, 2021 [36] | Low | Control group (n = 100) | 10.3 (6–15) | 3.0 | 1.0 | - |
Aboujaoude S, 2023 [37] | Low | Lebanese children (n = 112) | 10.5 (8–15) | 75.0 | 16.1 | - |
AlHudaithi FS, 2023 [38] | Moderate | Orthodontic patients (n = 384) | - (12–) | - | 7.3 | - |
Alanzi A, 2024 [39] | Moderate | Pediatric patients (n = 586) | - (8–12) | 20.1 | 9.3 | 0.5 |
Matošić Ž, 2024 [40] | Moderate | Female control group (n = 424) | - (20–40) | - | 3.5 | 0.9 |
Mohan R, 2024 [41] | Moderate | Non-syndromic pediatric patients (n = 581) | - (6–18) | 73.8 | 15.1 | 1.0 |
Author | Quality of Evidence | Subject | Mean Age [Years (Range)] | Dental Abnormalities (%) | Tooth Agenesis or Hypodontia (%) | Microdonts (%) |
---|---|---|---|---|---|---|
Lauritano D, 2012 [22] | Moderate | Children in long-term remission after leukemia treatment (n = 52) | 11.5 | - | 13.4 | 23.1 |
Tanaka M, 2017 [42] | Low | Childhood cancer survivors (n = 56) | 13.9 (4.6–32.7) | 46.4 | 16.1 | 21.4 |
Kang CM, 2018 [43] | Moderate | Childhood cancer survivors (n = 196) | 15.6 | 55.6 | 20.4 | 30.6 |
Kılınç G, 2019 [33] | Moderate | Pediatric patients diagnosed with cancer and treated (n = 93) | 9.5 (8–13) | 83.9 | 22.6 | 64.5 |
Immonen E, 2021 [44] | Moderate | Leukemia survivors (n = 178) | 5.0 | 39.3 | - | - |
Akitomo T, 2024 [45] | Moderate | Patients who received chemotherapy (n = 32) | - (7–) | 46.9 | 25.0 | 9.4 |
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Akitomo, T.; Tsuge, Y.; Mitsuhata, C.; Nomura, R. A Narrative Review of the Association between Dental Abnormalities and Chemotherapy. J. Clin. Med. 2024, 13, 4942. https://doi.org/10.3390/jcm13164942
Akitomo T, Tsuge Y, Mitsuhata C, Nomura R. A Narrative Review of the Association between Dental Abnormalities and Chemotherapy. Journal of Clinical Medicine. 2024; 13(16):4942. https://doi.org/10.3390/jcm13164942
Chicago/Turabian StyleAkitomo, Tatsuya, Yasuko Tsuge, Chieko Mitsuhata, and Ryota Nomura. 2024. "A Narrative Review of the Association between Dental Abnormalities and Chemotherapy" Journal of Clinical Medicine 13, no. 16: 4942. https://doi.org/10.3390/jcm13164942