An Association between HTRA1 and TGF-β2 in the Vitreous Humor of Patients with Chorioretinal Vascular Diseases
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Participants
2.3. Ophthalmic Examinations
2.4. Collection of Vitreous Humor
2.5. Measurement of TGF-, TGF-, TGF- and VEGF in the Vitreous Humor
2.6. Measurement of HTRA1 in the Vitreous Humor
2.7. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
HTRA1 | Human high-temperature requirement A 1 |
AMD | Age-related macular degeneration |
TGF- | Transforming growth factor beta |
VEGF | Vascular endothelial growth factor |
DR | Diabetic retinopathy |
RVO | Optical coherence tomography |
FA | Fluorescein angiography |
non-PDR | Non-proliferative diabetic retinopathy |
DME | Diabetic macular edema |
BRVO | Branch retinal vein occlusion |
CI | Confidence interval |
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Characteristics | Control (n = 6) | Chorioretinal Vascular Disease (n = 7) | p Value |
---|---|---|---|
Male Gender no. (%) | 4 (66.67%) | 4 (57.14%) | 0.93 |
Age (years); mean ± SD 1 | 67.17 ± 2.79 | 71.57 ± 10.91 | 0.40 |
Disease Duration (mo); mean ± SD 1 | 11.50 ± 14.56 | 8.43 ± 10.91 | 0.70 |
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Fukushima, Y.; Takahashi, S.; Nakamura, M.; Inoue, T.; Fujieda, Y.; Sato, T.; Noguchi, S.; Tsujikawa, M.; Sakaguchi, H.; Nishida, K. An Association between HTRA1 and TGF-β2 in the Vitreous Humor of Patients with Chorioretinal Vascular Diseases. J. Clin. Med. 2024, 13, 5073. https://doi.org/10.3390/jcm13175073
Fukushima Y, Takahashi S, Nakamura M, Inoue T, Fujieda Y, Sato T, Noguchi S, Tsujikawa M, Sakaguchi H, Nishida K. An Association between HTRA1 and TGF-β2 in the Vitreous Humor of Patients with Chorioretinal Vascular Diseases. Journal of Clinical Medicine. 2024; 13(17):5073. https://doi.org/10.3390/jcm13175073
Chicago/Turabian StyleFukushima, Yoko, Shizuka Takahashi, Machiko Nakamura, Tatsuya Inoue, Yusuke Fujieda, Toshiyuki Sato, Shingo Noguchi, Motokazu Tsujikawa, Hirokazu Sakaguchi, and Kohji Nishida. 2024. "An Association between HTRA1 and TGF-β2 in the Vitreous Humor of Patients with Chorioretinal Vascular Diseases" Journal of Clinical Medicine 13, no. 17: 5073. https://doi.org/10.3390/jcm13175073