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Volume 14
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10.3390/jcm14092971
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Background:
Systematic Review

The Use of Integra Dermal Regeneration Template in Exposed Bone Reconstruction: A Case Report with Systematic Literature Review

by
Marko S. Jović
1,2,*,†,
Branko J. Suđecki
1,†,
Ivan Ljubiša Radosavljević
1,
Milan D. Jovanović
1,2,
Milan T. Stojičić
1,2,
Jelena D. Isaković Subotić
1,
Nataša D. Nejković
3,
Zorka M. Inić
2,4,
Marina M. Stojanović
2,3 and
Jelena V. Jeremić
1,2
1
Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia
2
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
3
Center for Anesthesiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia
4
Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2025, 14(9), 2971; https://doi.org/10.3390/jcm14092971
Submission received: 19 March 2025 / Revised: 10 April 2025 / Accepted: 11 April 2025 / Published: 25 April 2025
(This article belongs to the Special Issue Clinical Management and Outcomes in Wound Healing)
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Abstract

Background/Objectives: Integra Dermal Regeneration Template (IDRT) has emerged as a viable reconstructive option in exposed avascular structures, such as exposed bone devoid of periosteum. This systematic review aimed at examining success rates by comparing different wound types and their characteristics, as well as the surgical methods involved. Methods: A systematic review was conducted to identify studies using IDRT in the reconstruction of defects with exposed bone devoid of periosteum. Primary outcomes of interest were IDRT and skin graft success rates, followed by patient and wound characteristics, and different surgical methods used. The results were accompanied by an illustrative case report of IDRT-based hand reconstruction after a deep burn injury. Results: The review included 40 studies, with a total of 202 individual defects. The primary indication for IDRT-based reconstruction was post-oncologic defects in the elderly population. Although surgeons mostly used burring/fenestration as a bone preparation method prior to IDRT placement, decorticated bones showed faster grafting time (23.8 vs. 27.9 days). The average success rate of IDRT was 87.54% (±25.9), with an excellent IDRT take rate (100%) observed in more than 50% of cases. In the majority of cases (95.5%), the skin graft acceptance rate was deemed to be higher than 95%, with an average graft take of 98.8%. Conclusions: The results of this review support the use of IDRT in managing complex defects involving exposed bone, offering fast coverage with good functional restoration, without any donor site morbidity. Additionally, bone preparation methods also play an important role in IDRT-based reconstruction by shortening the grafting time.
Keywords: Integra; burns; bone devoid of periosteum; burring; dermal regeneration template; bone; scalp; skin grafting Integra; burns; bone devoid of periosteum; burring; dermal regeneration template; bone; scalp; skin grafting

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MDPI and ACS Style

Jović, M.S.; Suđecki, B.J.; Radosavljević, I.L.; Jovanović, M.D.; Stojičić, M.T.; Isaković Subotić, J.D.; Nejković, N.D.; Inić, Z.M.; Stojanović, M.M.; Jeremić, J.V. The Use of Integra Dermal Regeneration Template in Exposed Bone Reconstruction: A Case Report with Systematic Literature Review. J. Clin. Med. 2025, 14, 2971. https://doi.org/10.3390/jcm14092971

AMA Style

Jović MS, Suđecki BJ, Radosavljević IL, Jovanović MD, Stojičić MT, Isaković Subotić JD, Nejković ND, Inić ZM, Stojanović MM, Jeremić JV. The Use of Integra Dermal Regeneration Template in Exposed Bone Reconstruction: A Case Report with Systematic Literature Review. Journal of Clinical Medicine. 2025; 14(9):2971. https://doi.org/10.3390/jcm14092971

Chicago/Turabian Style

Jović, Marko S., Branko J. Suđecki, Ivan Ljubiša Radosavljević, Milan D. Jovanović, Milan T. Stojičić, Jelena D. Isaković Subotić, Nataša D. Nejković, Zorka M. Inić, Marina M. Stojanović, and Jelena V. Jeremić. 2025. "The Use of Integra Dermal Regeneration Template in Exposed Bone Reconstruction: A Case Report with Systematic Literature Review" Journal of Clinical Medicine 14, no. 9: 2971. https://doi.org/10.3390/jcm14092971

APA Style

Jović, M. S., Suđecki, B. J., Radosavljević, I. L., Jovanović, M. D., Stojičić, M. T., Isaković Subotić, J. D., Nejković, N. D., Inić, Z. M., Stojanović, M. M., & Jeremić, J. V. (2025). The Use of Integra Dermal Regeneration Template in Exposed Bone Reconstruction: A Case Report with Systematic Literature Review. Journal of Clinical Medicine, 14(9), 2971. https://doi.org/10.3390/jcm14092971

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