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Article

Uncomplicated SARS-CoV-2 Infections with Preserved Lung Function in Pediatric Patients with Cystic Fibrosis: A Three-Year Single-Centre Experience

by
Justyna Sieber
1,†,
Nicole Martin
1,†,
Klara Schmidthaler
1,
René Gaupmann
1,
Eleonora Dehlink
1,
Alexandra Graf
2,
Zsolt Szépfalusi
1 and
Saskia Gruber
1,*
1
Division of Pediatric Pulmonology, Allergy and Endocrinology, Department of Pediatrics and Adolescent Medicine, Comprehensive Centre of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria
2
Institute of Medical Statistics, Centre for Medical Data Science, Medical University of Vienna, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2025, 14(9), 2979; https://doi.org/10.3390/jcm14092979
Submission received: 11 March 2025 / Revised: 20 April 2025 / Accepted: 22 April 2025 / Published: 25 April 2025
(This article belongs to the Special Issue Cystic Fibrosis: Clinical Manifestations and Treatment)
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Abstract

Background/Objectives: Patients with chronic lung diseases, such as cystic fibrosis, were considered a risk group for a severe course of coronavirus disease 2019 at the beginning of the pandemic. However, mounting evidence suggests that this group may not face an elevated risk for a severe SARS-CoV-2 infection. Methods: Here, we present data on the incidence and clinical course of SARS-CoV-2 infections in a single pediatric CF centre in Austria. Clinical variables were analyzed for their potential impact on disease acquisition and severity. A total of 135 young people with CF were assessed from February 2020 until December 2022. Results: Eighty-four patients were infected with SARS-CoV-2, out of which nine patients reported re-infection, resulting in 93 SARS-CoV-2 infections. Most infections, 76/93 (82%), occurred during the period of omicron variant predominance. Higher body mass index and respiratory colonization with Haemophilus influenzae before the beginning of the pandemic were significantly associated with the risk of acquiring SARS-CoV-2 infection. All patients had an uncomplicated COVID-19 course, regardless of the SARS-CoV-2 variant and COVID-19 vaccine status at infection. The most frequent symptoms were rhinitis (53%), fatigue (49%), cephalea (43%), and fever (38%). Neither oxygen therapy nor hospitalization were needed for any of the patients. Lung function parameters (FEV1, FVC, FEF50, LCI), both in the early post-viral as well as late post-viral stages, were not significantly impacted by SARS-CoV-2 infections. No long-term post-COVID-19 effects were reported. Conclusions: Our single-centre experience suggests that the course of SARS-CoV-2 infections in children and adolescents with CF is primarily mild and uncomplicated.
Keywords: cystic fibrosis; COVID-19; SARS-CoV-2; child; susceptibility cystic fibrosis; COVID-19; SARS-CoV-2; child; susceptibility

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MDPI and ACS Style

Sieber, J.; Martin, N.; Schmidthaler, K.; Gaupmann, R.; Dehlink, E.; Graf, A.; Szépfalusi, Z.; Gruber, S. Uncomplicated SARS-CoV-2 Infections with Preserved Lung Function in Pediatric Patients with Cystic Fibrosis: A Three-Year Single-Centre Experience. J. Clin. Med. 2025, 14, 2979. https://doi.org/10.3390/jcm14092979

AMA Style

Sieber J, Martin N, Schmidthaler K, Gaupmann R, Dehlink E, Graf A, Szépfalusi Z, Gruber S. Uncomplicated SARS-CoV-2 Infections with Preserved Lung Function in Pediatric Patients with Cystic Fibrosis: A Three-Year Single-Centre Experience. Journal of Clinical Medicine. 2025; 14(9):2979. https://doi.org/10.3390/jcm14092979

Chicago/Turabian Style

Sieber, Justyna, Nicole Martin, Klara Schmidthaler, René Gaupmann, Eleonora Dehlink, Alexandra Graf, Zsolt Szépfalusi, and Saskia Gruber. 2025. "Uncomplicated SARS-CoV-2 Infections with Preserved Lung Function in Pediatric Patients with Cystic Fibrosis: A Three-Year Single-Centre Experience" Journal of Clinical Medicine 14, no. 9: 2979. https://doi.org/10.3390/jcm14092979

APA Style

Sieber, J., Martin, N., Schmidthaler, K., Gaupmann, R., Dehlink, E., Graf, A., Szépfalusi, Z., & Gruber, S. (2025). Uncomplicated SARS-CoV-2 Infections with Preserved Lung Function in Pediatric Patients with Cystic Fibrosis: A Three-Year Single-Centre Experience. Journal of Clinical Medicine, 14(9), 2979. https://doi.org/10.3390/jcm14092979

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