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Journal of Functional Biomaterials, Volume 10, Issue 1

2019 March - 16 articles

Cover Story: Brushite (DCPD) is among the possible precursors of the inorganic phase of the hard tissues of vertebrates. Herein, we investigated the role of aspartic acid (ASP) and poly-aspartic acid (PASP), as models of the acidic macromolecules of biomineralized tissues, on the synthesis and hydrolysis of DCPD. The results indicate that ASP is not significantly incorporated into DCPD, whereas functionalization with PASP occurs up to about 2.3 wt.%. PASP shows a greater influence than ASP also on the hydrolysis of DCPD into more stable phases, thanks to the cooperative action of the carboxylate groups and to its good fit with DCPD structure. View this paper.
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Articles (16)

  • Review
  • Open Access
37 Citations
10,521 Views
18 Pages

The conventional applicability of biomaterials in the field of bone tissue engineering takes into consideration several key parameters to achieve desired results for prospective translational use. Hence, several engineering strategies have been devel...

  • Article
  • Open Access
43 Citations
9,854 Views
14 Pages

Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass

  • Jonathan Hatton,
  • Graham Roy Davis,
  • Abdel-Hamid I. Mourad,
  • Nizamudeen Cherupurakal,
  • Robert G. Hill and
  • Sahar Mohsin

Porous composite scaffold using an alginate and bioactive glass ICIE16M was synthesized by a simple freeze-drying technique. The scaffold was characterized using compression testing, Fourier-transform infrared spectroscopy (FTIR), differential scanni...

  • Article
  • Open Access
36 Citations
8,691 Views
11 Pages

Six-Month Color Stability Assessment of Two Calcium Silicate-Based Cements Used in Regenerative Endodontic Procedures

  • Paulo J. Palma,
  • Joana A. Marques,
  • Rui I. Falacho,
  • Eder Correia,
  • Alexandra Vinagre,
  • João Miguel Santos and
  • João C. Ramos

Aim: The purpose of the present study is to assess the color stability of two calcium silicate-based cements (CSCs) used in regenerative endodontic procedures (REPs). Methods: A total of 40 acrylic single-rooted transparent teeth, with immature apex,...

  • Article
  • Open Access
22 Citations
7,509 Views
16 Pages

Effect of Calcium Precursor on the Bioactivity and Biocompatibility of Sol-Gel-Derived Glasses

  • Alejandra Ruiz-Clavijo,
  • Andrew P. Hurt,
  • Arun K. Kotha and
  • Nichola J. Coleman

This study investigated the impact of different calcium reagents on the morphology, composition, bioactivity and biocompatibility of two-component (CaO-SiO2) glasses produced by the Stöber process with respect to their potential application in g...

  • Article
  • Open Access
19 Citations
8,677 Views
21 Pages

A synthetic technique inspired by the biomineralisation process in nacre has been previously reported to be effective in replicating the nanostructural elements of nacre in 2D chitosan hydrogel films. Here we evaluate the applicability of this synthe...

  • Article
  • Open Access
24 Citations
8,602 Views
12 Pages

Dicalcium phosphate dihydrate (DCPD) is one of the mineral phases indicated as possible precursors of biological apatites and it is widely employed in the preparation of calcium phosphate bone cements. Herein, we investigated the possibility to funct...

  • Feature Paper
  • Review
  • Open Access
11 Citations
7,482 Views
34 Pages

Biomaterial enhanced regeneration (BER) falls mostly under the broad heading of Tissue Engineering: the use of materials (synthetic and natural) usually in conjunction with cells (both native and genetically modified as well as stem cells) and/or bio...

  • Feature Paper
  • Review
  • Open Access
60 Citations
10,976 Views
7 Pages

3D printing of polymers can now be considered as a common processing technology for the development of biomaterials. These can be constituted out of polymeric abiotic material alone or can be co-printed with living cells. However, the adaptive and sh...

  • Retraction
  • Open Access
1 Citations
6,676 Views

Due to human error, the authors included some of the experimental data in this article [...]

  • Feature Paper
  • Article
  • Open Access
19 Citations
7,359 Views
12 Pages

Evaluation of Osteoconduction of Biphasic Calcium Phosphate Ceramic in the Calvaria of Rats: Microscopic and Histometric Analysis

  • Igor de Oliveira Puttini,
  • Pier Paolo Poli,
  • Carlo Maiorana,
  • Igor Rodrigues de Vasconcelos,
  • Luis Eduardo Schmidt,
  • Luara Teixeira Colombo,
  • Henrique Hadad,
  • Gabriel Mulinari dos Santos,
  • Paulo Sergio Perri de Carvalho and
  • Francisley Ávila Souza

(1) Background: Evaluate the osteoconduction capability of a biphasic calcium phosphate (BCP) ceramic composed of hydroxyapatite and β-tricalcium phosphate 60%/40% in a rat model. (2) Methods: In the calvarial bone of 54 adult male rats, 7-mm di...

  • Article
  • Open Access
5 Citations
7,081 Views
14 Pages

Assessment of Dental Implants with Modified Calcium-Phosphate Surface in a Multicenter, Prospective, Non-Interventional Study: Results up to 50 Months of Follow-Up

  • Carles Subirà-Pifarré,
  • Cristina Masuet-Aumatell,
  • Carlos Rodado Alonso,
  • Ricardo Medina Madrid and
  • Cosimo Galletti

Prescription of implant treatments is very widespread at present, mainly due to the low rate of annual loss and, to date, few studies have assessed their survival in the routine clinical practice of dentistry. The purpose of this observational study...

  • Review
  • Open Access
401 Citations
18,281 Views
15 Pages

Biocompatible Polymer Nanoparticles for Drug Delivery Applications in Cancer and Neurodegenerative Disorder Therapies

  • Eleonora Calzoni,
  • Alessio Cesaretti,
  • Alice Polchi,
  • Alessandro Di Michele,
  • Brunella Tancini and
  • Carla Emiliani

Polymer nanoparticles (NPs) represent one of the most innovative non-invasive approaches for drug delivery applications. NPs main objective is to convey the therapeutic molecule be they drugs, proteins, or nucleic acids directly into the target organ...

  • Review
  • Open Access
165 Citations
16,215 Views
36 Pages

Periodontal diseases involve injuries to the supporting structures of the tooth and, if left untreated, can lead to the loss of the tooth. Regenerative periodontal therapies aim, ideally, at healing all the damaged periodontal tissues and represent a...

  • Article
  • Open Access
17 Citations
7,232 Views
12 Pages

Chronic dermal lesions, such as pressure ulcers, are difficult to heal. Degradable tissue scaffold systems can be employed to serve as a provisional matrix for cellular ingrowth and facilitate regenerative healing during degradation. Degradable regen...

  • Review
  • Open Access
26 Citations
8,919 Views
24 Pages

A Critical Review on Selected External Physical Cues and Modulation of Cell Behavior: Magnetic Nanoparticles, Non-thermal Plasma and Lasers

  • Barbora Smolková,
  • Mariia Uzhytchak,
  • Anna Lynnyk,
  • Šárka Kubinová,
  • Alexandr Dejneka and
  • Oleg Lunov

Physics-based biomedical approaches have proved their importance for the advancement of medical sciences and especially in medical diagnostics and treatments. Thus, the expectations regarding development of novel promising physics-based technologies...

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J. Funct. Biomater. - ISSN 2079-4983