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Article

Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants

by
Marijana R. Pantović Pavlović
1,2,*,
Nenad L. Ignjatović
3,
Vladimir V. Panić
1,2,4,
Ivana I. Mirkov
5,
Jelena B. Kulaš
5,
Anastasija Lj. Malešević
5 and
Miroslav M. Pavlović
1,2,*
1
Department of Electrochemistry, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia
2
Center of Excellence in Chemistry and Environmental Engineering—ICTM, University of Belgrade, 11000 Belgrade, Serbia
3
Institute of Technical Science of the Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia
4
Department of Chemical-Technological Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia
5
Immunotoxicology Group, Department of Ecology, Institute for Biological Research “Sinisa Stankovic”—National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2023, 14(4), 227; https://doi.org/10.3390/jfb14040227
Submission received: 28 March 2023 / Revised: 11 April 2023 / Accepted: 16 April 2023 / Published: 18 April 2023
(This article belongs to the Section Dental Biomaterials)
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Abstract

The aim of this work is in situ anodization/anaphoretic deposition of a nano amorphous calcium phosphate (ACP)/chitosan oligosaccharide lactate (ChOL) multifunctional hybrid coating decorated with selenium (Se) on a titanium substrate and in vivo investigation of its immunomodulatory and anti-inflammatory effect. Investigating phenomena at the implant–tissue interface of interest for controlled inflammation and immunomodulation was also the aim of the research. In our earlier research, we designed coatings based on ACP and ChOL on titanium with anticorrosive, antibacterial and biocompatible properties, while in the presented results we show that selenium addition makes this coating an immunomodulator. The immunomodulatory effect of the novel hybrid coating is characterized by the examination of the functional aspects in the tissue around the implant (in vivo): proinflammatory cytokines’ gene expression, M1 (iNOS) and M2 (Arg1) macrophages, fibrous capsule formation (TGF-β) and vascularization (VEGF). The EDS, FTIR and XRD analyses prove the formation of a ACP/ChOL/Se multifunctional hybrid coating on Ti and the presence of Se. A higher M2/M1 macrophage ratio in the ACP/ChOL/Se-coated implants compared to pure titanium implants (a higher level of Arg1 expression) is noted at all time points examined (after 7, 14 and 28 days). Lower inflammation measured by gene expression of proinflammatory cytokines IL-1β and TNF, lower expression of TGF-β in the surrounding tissue and higher IL-6 expression (solely at day 7 post-implantation) is noted in presence of the ACP/ChOL/Se-coated implants.
Keywords: deposition; hybrid coating; immunomodulation; implants; inflammatory mediators; nano calcium phosphate deposition; hybrid coating; immunomodulation; implants; inflammatory mediators; nano calcium phosphate
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MDPI and ACS Style

Pantović Pavlović, M.R.; Ignjatović, N.L.; Panić, V.V.; Mirkov, I.I.; Kulaš, J.B.; Malešević, A.L.; Pavlović, M.M. Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants. J. Funct. Biomater. 2023, 14, 227. https://doi.org/10.3390/jfb14040227

AMA Style

Pantović Pavlović MR, Ignjatović NL, Panić VV, Mirkov II, Kulaš JB, Malešević AL, Pavlović MM. Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants. Journal of Functional Biomaterials. 2023; 14(4):227. https://doi.org/10.3390/jfb14040227

Chicago/Turabian Style

Pantović Pavlović, Marijana R., Nenad L. Ignjatović, Vladimir V. Panić, Ivana I. Mirkov, Jelena B. Kulaš, Anastasija Lj. Malešević, and Miroslav M. Pavlović. 2023. "Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants" Journal of Functional Biomaterials 14, no. 4: 227. https://doi.org/10.3390/jfb14040227

APA Style

Pantović Pavlović, M. R., Ignjatović, N. L., Panić, V. V., Mirkov, I. I., Kulaš, J. B., Malešević, A. L., & Pavlović, M. M. (2023). Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants. Journal of Functional Biomaterials, 14(4), 227. https://doi.org/10.3390/jfb14040227

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