Preventive Antibiotic Therapy in the Placement of Immediate Implants: A Systematic Review
Abstract
:1. Introduction
2. Material and Methods
2.1. Focused Question
2.2. Clinical Relevance
2.3. Eligibility Criteria
2.3.1. Inclusion Criteria
2.3.2. Exclusion Criteria
2.4. Information Sources and Search Strategy
2.5. Study Records
2.6. Risk of Bias
3. Results
3.1. Study Selection
3.2. Study Characteristics
3.3. Risk of Bias within Studies
4. Discussion
Strengths and Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Component | Description |
---|---|
P (problem/population) | Patients undergoing immediate DI 1 placement, with or without the presence of chronic infection of the tooth to be extracted |
I (intervention) | PAs 2 on the day of surgery and/or extended postoperatively |
C (comparison) | Not prescribing PAs Prescribing a placebo Other antibiotics or antibiotic regimens Same antibiotic with different dosage/duration |
O (outcome) | DI failure Postoperative infection |
PICO question | In patients undergoing immediate implant placement, with or without infection of the tooth to be extracted, does the prescription of PAs decrease early implant failure rates compared to not prescribing them? |
Author(s)/Year | Type of Study | No. 1 Patients/No. Immediate DI 2 | Immediate DI Failure Rate (%) | Follow-Up (Months) | Conclusions |
---|---|---|---|---|---|
Cosyn et al. [26] (2019) | SR 3 and M-A 4 | 232/ 233 | 5.1 | 12–96 | Tendency for lower survival of immediate implants in the absence of PostOp 5 PAs 6 |
French et al. [28] (2016) | Cohort study | UNS 7/ 687 | 1.7 | 120 | The failure rate of immediate DI in SRPA 8 patients prescribed with clindamycin is 10 times higher than in the group prescribed with amoxicillin |
Lee et al. [25] (2015) | SR | UNS/ 89 | UNS | 12–120 | In favour of prescribing PAs in infected sites. It is not possible to recommend a guideline |
Chrcanovic et al. [11] (2013) | SR | 1259/ 1735 | 1.7 | 3–297 | The most frequent pattern was PeriOp 9. It is not possible to draw a conclusion on the use of PAs in cases. |
Álvarez-Camino et al. [24] (2013) | SR | NA 10 | UNS | UNS | In favour of prescribing PA in infected sites. It is not possible to recommend a guideline. |
Lang et al. [22] (2012) | SR | 2073/ 2908 | PreOp 11 PAs = 1.87 PostOp PAs = 0.51 PeriOp PAs = 0.75 | 56 | PreOp prophylaxis is not sufficient, however, for 5–7 days PostOp may help prevent PostOp infections |
Waasdorp et al. [23] (2010) | SR | 186/ 324 | 0–8.0 | 7–72 | They recommend prescribing PAs for immediate implants in infected sites |
Esposito et al. [27] (2010) | RCT 12 | 99/ 136 | 9.0% | 4 | They found no evidence that 2 g amoxicillin 1 h PreOp reduces early failure in immediate implants vs. placebo |
Items | Cosyn et al. [26] (2019) | Lee et al. [25] (2015) | Chrcanovic et al. [11] (2013) | Alvarez-Camino et al. [24] (2013) | Lang et al. [22] (2012) | Waasdorp et al. [23] (2010) |
---|---|---|---|---|---|---|
Section 1: Internal Validity | ||||||
The research question is clearly defined, and the inclusion/exclusion criteria must be listed in the paper | | | | | | |
A comprehensive literature search is carried out | | | | | | |
At least two people should have selected studies | | | | | | |
The status of publication was not used as inclusion criterion | | | | | | |
The excluded studies are listed | | | | | | |
The relevant characteristics of the included studies are provided | | | | | | |
The scientific quality of the included studies was assessed and reported | | | | | | |
Was the scientific quality of the included studies used appropriately? | | | | | | |
Appropriate methods are used to combine the individual study findings | | | | | | |
The likelihood of publication bias was assessed appropriately | | | | | | |
Conflicts of interest are declared | | | | | | |
Section 2: Overall Assessment of the Study | ||||||
Are the results of this study directly applicable to the patient group targeted by this guideline? | | | | | | |
What is your overall assessment of the methodological quality of this review? | High Quality 1 | Acceptable 2 | High Quality | Low Quality 3 | High Quality | Acceptable |
Items | French et al. [28] (2016) | Esposito et al. [27] (2010) |
---|---|---|
1. Was the sample representative of the target population? | | |
2. Were study participants recruited in an appropriate way? | | |
3. Was the sample size adequate? | | |
4. Were the study subjects and setting described in detail? | | |
5. Is the data analysis conducted with sufficient coverage of the identified sample? | | |
6. Were objective, standard criteria used for measurement of the condition? | | |
7. Was the condition measured reliably? | | |
8. Was there appropriate statistical analysis? | | |
9. Are all the important cofounding factors/subgroups/differences identified and accounted for? | | |
10. Were subpopulation identified using objective criteria? | | |
Antibiotic | PreOp 1 Dose (1 h 3 before) | PostOp 2 Dose (5–7 days) | |
---|---|---|---|
Amoxicillin | 2–3 g | 500 mg/8 h | |
Beta-lactam antibiotic allergy | Clindamycin | 600 mg 4 | 300 mg/6 h |
Azithromycin | 500 mg | 250 mg/24 h | |
Clarithromycin | 500 mg | 250 mg/12 h | |
Metronidazole | 1 g 5 | 500 mg/6 h |
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Share and Cite
Salgado-Peralvo, A.-O.; Peña-Cardelles, J.-F.; Kewalramani, N.; Mateos-Moreno, M.-V.; Jiménez-Guerra, Á.; Velasco-Ortega, E.; Uribarri, A.; Moreno-Muñoz, J.; Ortiz-García, I.; Núñez-Márquez, E.; et al. Preventive Antibiotic Therapy in the Placement of Immediate Implants: A Systematic Review. Antibiotics 2022, 11, 5. https://doi.org/10.3390/antibiotics11010005
Salgado-Peralvo A-O, Peña-Cardelles J-F, Kewalramani N, Mateos-Moreno M-V, Jiménez-Guerra Á, Velasco-Ortega E, Uribarri A, Moreno-Muñoz J, Ortiz-García I, Núñez-Márquez E, et al. Preventive Antibiotic Therapy in the Placement of Immediate Implants: A Systematic Review. Antibiotics. 2022; 11(1):5. https://doi.org/10.3390/antibiotics11010005
Chicago/Turabian StyleSalgado-Peralvo, Angel-Orión, Juan-Francisco Peña-Cardelles, Naresh Kewalramani, María-Victoria Mateos-Moreno, Álvaro Jiménez-Guerra, Eugenio Velasco-Ortega, Andrea Uribarri, Jesús Moreno-Muñoz, Iván Ortiz-García, Enrique Núñez-Márquez, and et al. 2022. "Preventive Antibiotic Therapy in the Placement of Immediate Implants: A Systematic Review" Antibiotics 11, no. 1: 5. https://doi.org/10.3390/antibiotics11010005