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Article
Peer-Review Record

Enhancement of Skin Permeation and Penetration of β-Arbutin Fabricated in Chitosan Nanoparticles as the Delivery System

Cosmetics 2022, 9(6), 114; https://doi.org/10.3390/cosmetics9060114
by Shariza Sahudin 1,*, Nursyafiqah Sahrum Ayumi 1 and Norsavina Kaharudin 2
Reviewer 2: Anonymous
Cosmetics 2022, 9(6), 114; https://doi.org/10.3390/cosmetics9060114
Submission received: 23 August 2022 / Revised: 9 September 2022 / Accepted: 15 September 2022 / Published: 3 November 2022
(This article belongs to the Special Issue Nanoparticles for Cosmetic Use and Their Application)

Round 1

Reviewer 1 Report

The study is clear and welldone treating a topic of Great interest for dermatologists and Cosmetic chemists. It will be necessary further studies to verify the eventual topic side effects due to to the arbutin.

Author Response

Yes, I agree with the reviewer. I have added in the conclusion for further studies to ascertain the side effects of the nanoparticles in vivo  using animal studies

Author Response File: Author Response.docx

Reviewer 2 Report

Comment 1

Please specify the category of products (e.i. drugs or cosmetics) for the data given in the first sentence of the Introduction.

Comment 2

For In vitro Permeation study provide the information of the skin origin.

Comment 3

Which statistical program was used for analysis?

 

Author Response

Comment 1: I have specified creams and lotions

Comment 2: I have specified skin of wistar rats

Comment 3: I have specified using the Statistical Package for the Social Sciences (SPSS, Version 26.0 SPSS Inc., Chicago, IL, USA) for statistical analysis. 

Author Response File: Author Response.docx

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