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Scientia Pharmaceutica, Volume 88, Issue 2

2020 June - 13 articles

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Articles (13)

  • Review
  • Open Access
28 Citations
18,142 Views
12 Pages

Remdesivir—Bringing Hope for COVID-19 Treatment

  • Naser F. Al-Tannak,
  • Ladislav Novotny and
  • Adel Alhunayan

At the beginning of 2020, the world was swept with a wave of a new coronavirus disease, named COVID-19 by the World Health Organization (WHO 2). The causative agent of this infection is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...

  • Review
  • Open Access
37 Citations
18,835 Views
17 Pages

Contribution of Topical Antioxidants to Maintain Healthy Skin—A Review

  • Tércio Elyan Azevedo Martins,
  • Claudinéia Aparecida Sales de Oliveira Pinto,
  • Andressa Costa de Oliveira,
  • Maria Valéria Robles Velasco,
  • Arilmí Rosa Gorriti Guitiérrez,
  • Martha Francisca Cosquillo Rafael,
  • Jossimar Paúl Huamaní Tarazona and
  • Mónica Guadalupe Retuerto-Figueroa

The skin is constantly exposed to various environmental stresses, in particular to the damage caused by pollution and ultraviolet radiation (UV), and as a consequence, the horny extract can be negatively impacted by the harmful influence of some of i...

  • Article
  • Open Access
19 Citations
9,040 Views
14 Pages

Melatonin Potentiates the Therapeutic Effects of Metformin in Women with Metabolic Syndrome

  • Sattar J. Abood,
  • Waleed K. Abdulsahib,
  • Saad A. Hussain and
  • Sajida H. Ismail

Objective: This study evaluated the effect of melatonin on the response of patients suffering from metabolic syndrome (MEBS) treated with metformin. Design: This study used two-armed groups in a double-blind, randomized controlled clinical trial. Mat...

  • Article
  • Open Access
16 Citations
11,169 Views
13 Pages

Evaluation of Topical Anti-Inflammatory Effects of a Gel Formulation with Plantago Lanceolata, Achillea Millefolium, Aesculus Hippocastanum and Taxodium Distichum

  • Anca Zanfirescu,
  • Georgiana Nitulescu,
  • Gheorghe Stancov,
  • Denise Radulescu,
  • Cosmin Trif,
  • George Mihai Nitulescu,
  • Simona Negres and
  • Octavian Tudorel Olaru

Medicinal plants hold a significant place as alternative treatments available for inflammatory diseases, with many phytoconstituents being frequently tested in vitro for their biological activities. In the current study, we investigated the in vivo a...

  • Communication
  • Open Access
1 Citations
9,893 Views
6 Pages

Medication Safety in Intravenous Therapy: A Compatibility Study and Analysis of Reaction Products of Dihydralazine and Metamizole

  • Anna Katharina Koller,
  • Oliver Fischer,
  • Sabine Krebs,
  • Markus R. Heinrich and
  • Frank Dörje

The pharmacotherapy of critically ill patients is challenging due to the variety of drugs that have to be applied. As the majority of pharmaceuticals must be administered intravenously because of the critical condition of the patients, the compatibil...

  • Article
  • Open Access
11 Citations
8,323 Views
18 Pages

Combined Approach to the Choice of Chromatographic Methods for Routine Determination of Hederacoside C in Ivy Leaf Extracts, Capsules, and Syrup

  • Ivan Bezruk,
  • Alla Kotvitska,
  • Iuliia Korzh,
  • Anna Materiienko,
  • Svitlana Gubar,
  • Liana Budanova,
  • Liudas Ivanauskas,
  • Igor Vyshnevsky and
  • Victoriya Georgiyants

Developed methods for routine analysis of medicines should be considered in terms of analytical efficiency, economic cost, as well as their environmental impact. Different chromatographic methods for the routine quantitative analysis of hederacoside...

  • Article
  • Open Access
16 Citations
10,568 Views
10 Pages

Michelia Essential Oil Inhalation Increases Fast Alpha Wave Activity

  • Phanit Koomhin,
  • Apsorn Sattayakhom,
  • Supaya Chandharakool,
  • Jennarong Sinlapasorn,
  • Sarunnat Suanjan,
  • Sarawoot Palipoch,
  • Prasit Na-ek,
  • Chuchard Punsawad and
  • Narumol Matan

Essential oils are volatile fragrance liquids extracted from plants, and their compound annual growth rate is expected to expand to 8.6% from 2019 to 2025, according to Grand View Research. Essential oils have several domains of application, such as...

  • Communication
  • Open Access
10 Citations
5,746 Views
9 Pages

Is the Botryococcus braunii Dry Biomass an Adjuvant for Anti-UVB Topical Formulations?

  • Maíra Bueno Ariede,
  • Ana Lucia Morocho-Jácome,
  • Thalita Marcílio Candido,
  • Felipe Rebello Lourenço,
  • Edna Tomiko Myiake Kato,
  • Fabiana Vieira Lima,
  • Catarina Rosado,
  • Maria Valéria Robles Velasco,
  • João Carlos Monteiro de Carvalho and
  • André Rolim Baby

Several topical products have been developed to avoid the harmful effects from ultraviolet (UV) radiation, such as sunscreens. Research for actives from natural sources is increasing due to the fact that chemical filters could induce adverse events....

  • Article
  • Open Access
59 Citations
9,420 Views
12 Pages

Improved Solubility and Dissolution Rates in Novel Multicomponent Crystals of Piperine with Succinic Acid

  • Erizal Zaini,
  • Afriyani,
  • Lili Fitriani,
  • Friardi Ismed,
  • Ayano Horikawa and
  • Hidehiro Uekusa

The objectives of this study were to prepare and characterize a novel piperine–succinic acid multicomponent crystal phase and to evaluate the improvement in the solubility and dissolution rate of piperine when prepared in the multicomponent cry...

  • Article
  • Open Access
13 Citations
18,964 Views
13 Pages

Topical Delivery of 3-O-ethyl l-ascorbic Acid from Complex Solvent Systems

  • Fotis Iliopoulos,
  • A. S. M. Monjur Al Hossain,
  • Bruno C. Sil,
  • David J. Moore,
  • Robert A. Lucas and
  • Majella E. Lane

3-O-ethyl l-ascorbic acid (EA), an ether derivative of Vitamin C, is widely used in skincare formulations. Previously, we reported the effects of neat solvents on EA percutaneous absorption and observed that 0.6–7.5% of the applied EA was deliv...

  • Article
  • Open Access
6 Citations
5,545 Views
12 Pages

Biodistribution and Anticancer Characteristics of Les-3833, A Novel 4-thiazolidinone-Based Lead Compound

  • Lesya Kobylinska,
  • Andrii Lozynskii,
  • Roman Lesyk,
  • Rostyslav Stoika and
  • Sandor G. Vari

Recently, we identified the promising anticancer potential of the synthetic 4-thiazolidinone-based anticancer lead compound Les-3833 which demonstrated tumor-suppressing action in vitro and in vivo. Based on the results of previous studies, the aim o...

  • Review
  • Open Access
36 Citations
15,255 Views
24 Pages

Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery possibilities presented by these u...

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Sci. Pharm. - ISSN 2218-0532