Next Article in Journal
L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine
Next Article in Special Issue
The Metano Modeling Toolbox MMTB: An Intuitive, Web-Based Toolbox Introduced by Two Use Cases
Previous Article in Journal
Trimethylornithine Membrane Lipids: Discovered in Planctomycetes and Identified in Diverse Environments
Previous Article in Special Issue
Flux Coupling and the Objective Functions’ Length in EFMs
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Metabolites
Volume 11
Issue 1
10.3390/metabo11010050
metabolites-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

In Vivo Metabolism of [1,6-13C2]Glucose Reveals Distinct Neuroenergetic Functionality between Mouse Hippocampus and Hypothalamus

by
Antoine Cherix
1,†,
Rajesh Sonti
1,‡,
Bernard Lanz
1 and
Hongxia Lei
2,3,*,§
1
Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
2
Animal Imaging and Technology (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
3
Faculty of Medicine, University of Geneva, CH-1206 Geneva, Switzerland
*
Author to whom correspondence should be addressed.
†
Current address: Wellcome Centre for Integrative Neuroimaging (WIN), Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
‡
Current address: Department of Pharmaceutical analysis, National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad- NH 65, Hyderabad 500037, India.
§
Current address: Wuhan United Imaging Life Science Instruments Ltd., Wuhan 430206, China.
Metabolites 2021, 11(1), 50; https://doi.org/10.3390/metabo11010050
Submission received: 14 December 2020 / Revised: 6 January 2021 / Accepted: 8 January 2021 / Published: 12 January 2021
(This article belongs to the Special Issue Computational Biology for Metabolic Modelling)
Browse Figures
Review Reports Versions Notes

Abstract

Glucose is a major energy fuel for the brain, however, less is known about specificities of its metabolism in distinct cerebral areas. Here we examined the regional differences in glucose utilization between the hypothalamus and hippocampus using in vivo indirect 13C magnetic resonance spectroscopy (1H-[13C]-MRS) upon infusion of [1,6-13C2]glucose. Using a metabolic flux analysis with a 1-compartment mathematical model of brain metabolism, we report that compared to hippocampus, hypothalamus shows higher levels of aerobic glycolysis associated with a marked gamma-aminobutyric acid-ergic (GABAergic) and astrocytic metabolic dependence. In addition, our analysis suggests a higher rate of ATP production in hypothalamus that is accompanied by an excess of cytosolic nicotinamide adenine dinucleotide (NADH) production that does not fuel mitochondria via the malate-aspartate shuttle (MAS). In conclusion, our results reveal significant metabolic differences, which might be attributable to respective cell populations or functional features of both structures.
Keywords: brain metabolism; in vivo imaging; mathematical modeling; metabolic flux analysis; 13C-MRS brain metabolism; in vivo imaging; mathematical modeling; metabolic flux analysis; 13C-MRS

Share and Cite

MDPI and ACS Style

Cherix, A.; Sonti, R.; Lanz, B.; Lei, H. In Vivo Metabolism of [1,6-13C2]Glucose Reveals Distinct Neuroenergetic Functionality between Mouse Hippocampus and Hypothalamus. Metabolites 2021, 11, 50. https://doi.org/10.3390/metabo11010050

AMA Style

Cherix A, Sonti R, Lanz B, Lei H. In Vivo Metabolism of [1,6-13C2]Glucose Reveals Distinct Neuroenergetic Functionality between Mouse Hippocampus and Hypothalamus. Metabolites. 2021; 11(1):50. https://doi.org/10.3390/metabo11010050

Chicago/Turabian Style

Cherix, Antoine, Rajesh Sonti, Bernard Lanz, and Hongxia Lei. 2021. "In Vivo Metabolism of [1,6-13C2]Glucose Reveals Distinct Neuroenergetic Functionality between Mouse Hippocampus and Hypothalamus" Metabolites 11, no. 1: 50. https://doi.org/10.3390/metabo11010050

APA Style

Cherix, A., Sonti, R., Lanz, B., & Lei, H. (2021). In Vivo Metabolism of [1,6-13C2]Glucose Reveals Distinct Neuroenergetic Functionality between Mouse Hippocampus and Hypothalamus. Metabolites, 11(1), 50. https://doi.org/10.3390/metabo11010050

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop