Alterations in Plasma Lipid Profile before and after Surgical Removal of Soft Tissue Sarcoma
Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsThe paper by Lee et al revealed distinct lipid profile alterations in STS patients after surgical removal of masses. potentially contribute to the elucidation of the pathophysiology of STS
Although the study utilizes several patients n=24, the PC lipids particularly represented in post-operative STS no confirmative data are presented
the discussion should include the role of these lipids which could be also to generate vesicles to transport miRNA or proteins in another body site
favoring metastasis add doi: 10.1038/s41419-021-04069-w.
Lane 53 STS are mesenchymal tumors
Comments on the Quality of English LanguageDear Editor, the paper by Lee et al revealed distinct lipid profile alterations in STS patients after surgical removal of masses. potentially contribute to the elucidation of the pathophysiology of STS
Although the study utilizes several patients n=24, the PC lipids particularly represented in post-operative STS no confirmative data are presented
the discussion should include the role of these lipids which could be also to generate vesicles to transport miRNA or proteins in another body site
favoring metastasis add doi: 10.1038/s41419-021-04069-w.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsThis article addresses a rare and therefore less studied type of cancer. The authors observed significant differences in the plasma metabolome of patients before and after surgery, in relation to lipid content. The main criticisms I would make would be regarding the lack of control samples from healthy subjects and the differences in sample collection time after surgery. It is very difficult to analyze the influence of wound healing in the post- surgery results if time is so variable. However, the authors themselves recognize these limitations in their study. Despite this, I consider that the article has merit and deserves to be published, given the fact that there are few studies on sarcomas. I suggest that the authors include a table (it could be as supplementary data) with information about the post-surgery collection time for each individual, as well as chemotherapy treatment and time when recurrence was detected.
Minor points:
1. There are some repeated sentences such as the ones in lines 28-30, 49-51 and 109-111. The text could be improved by combining these sentences.
2. Line 100, please inform that the plasma was frozen.
3. Lines 110-112. Chemosensitivity to which drugs? Please specify.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Reviewer 3 Report
Comments and Suggestions for AuthorsComments for author File: Comments.pdf
Comments on the Quality of English LanguageNo, thank you!
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Round 2
Reviewer 3 Report
Comments and Suggestions for AuthorsNo further comments on the current version.
Comments on the Quality of English LanguageNo.