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Biomolecules
Volume 10
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10.3390/biom10010101
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Article

Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications

by
Tse-Kai Fu
1,2,†,
Ping-Hsueh Kuo
1,†,
Yen-Chang Lu
1,
Hsing-Ni Lin
1,
Lily Hui-Ching Wang
1,3,
Yu-Chun Lin
4,
Yu-Chen Kao
4,
Huey-Min Lai
4,* and
Margaret Dah-Tsyr Chang
1,5,*
1
Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 30013, Taiwan
2
Research and Development Department, Simpson Biotech Co., Ltd., Taoyuan 333, Taiwan
3
Department of Medical Science, National Tsing Hua University, Hsinchu 30013, Taiwan
4
Industrial Technology Research Institute, Hsinchu 30011, Taiwan
5
Department of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2020, 10(1), 101; https://doi.org/10.3390/biom10010101
Submission received: 28 November 2019 / Revised: 26 December 2019 / Accepted: 4 January 2020 / Published: 7 January 2020
(This article belongs to the Special Issue Peptides: Molecular and Biotechnological Aspects)
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Abstract

Cosmeceutical peptides have become an important topic in recent decades in both academic and industrial fields. Many natural or synthetic peptides with different biological functions including anti-ageing, anti-oxidation, anti-infection and anti-pigmentation have been developed and commercialized. Current cosmeceutical peptides have already satisfied most market demand, remaining: “cargos carrying skin penetrating peptide with high safety” still an un-met need. To this aim, a cell-penetrating peptide, CPPAIF, which efficiently transported cargos into epithelial cells was exanimated. CPPAIF was evaluated with cell model and 3D skin model following OECD guidelines without using animal models. As a highly stable peptide, CPPAIF neither irritated nor sensitized skin, also did not disrupt skin barrier. In addition, such high safety peptide had anti-inflammation activity without allergic effect. Moreover, cargo carrying activity of CPPAIF was assayed using HaCaT cell model and rapid CPPAIF penetration was observed within 30 min. Finally, CPPAIF possessed transepidermal activity in water in oil formulation without disruption of skin barrier. All evidences indicated that CPPAIF was an ideal choice for skin penetrating and its anti-inflammatory activity could improve skin condition, which made CPPAIF suitable and attractive for novel cosmeceutical product development.
Keywords: cell-penetrating peptides; cosmeceutical peptides; anti-inflammation cell-penetrating peptides; cosmeceutical peptides; anti-inflammation

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MDPI and ACS Style

Fu, T.-K.; Kuo, P.-H.; Lu, Y.-C.; Lin, H.-N.; Wang, L.H.-C.; Lin, Y.-C.; Kao, Y.-C.; Lai, H.-M.; Chang, M.D.-T. Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications. Biomolecules 2020, 10, 101. https://doi.org/10.3390/biom10010101

AMA Style

Fu T-K, Kuo P-H, Lu Y-C, Lin H-N, Wang LH-C, Lin Y-C, Kao Y-C, Lai H-M, Chang MD-T. Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications. Biomolecules. 2020; 10(1):101. https://doi.org/10.3390/biom10010101

Chicago/Turabian Style

Fu, Tse-Kai, Ping-Hsueh Kuo, Yen-Chang Lu, Hsing-Ni Lin, Lily Hui-Ching Wang, Yu-Chun Lin, Yu-Chen Kao, Huey-Min Lai, and Margaret Dah-Tsyr Chang. 2020. "Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications" Biomolecules 10, no. 1: 101. https://doi.org/10.3390/biom10010101

APA Style

Fu, T.-K., Kuo, P.-H., Lu, Y.-C., Lin, H.-N., Wang, L. H.-C., Lin, Y.-C., Kao, Y.-C., Lai, H.-M., & Chang, M. D.-T. (2020). Cell Penetrating Peptide as a High Safety Anti-Inflammation Ingredient for Cosmetic Applications. Biomolecules, 10(1), 101. https://doi.org/10.3390/biom10010101

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