Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Data Collection
2.3. Laboratory Methods
2.4. Statistical Methods
3. Results
4. Discussion
4.1. NT-proBNP Levels Progosticate CV Death and MI Beyond hsCRP and hsTnI
4.2. Pathophysiologic Considerations
4.3. Future Perspectives
4.4. Study Limitations
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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SAP | ACS | p-Value | |
---|---|---|---|
n | 1,356 | 837 | |
Age (years) * | 64.0 (56.0, 70.0) | 63.0 (55.0, 70.0) | 0.61 |
Male No. (%) | 1045 (77.1) | 638 (76.2) | 0.69 |
BMI (kg/m2) * | 27.2 (25.0, 30.1) | 27.1 (24.9, 29.7) | 0.23 |
Diabetes No. (%) | 318 (23.5) | 171 (20.4) | 0.11 |
Current smoker No. (%) | 285 (21.0) | 235 (28.1) | <0.001 |
Dyslipidemia No. (%) | 1049 (77.4) | 539 (64.4) | <0.001 |
Hypertension No. (%) | 1108 (81.7) | 574 (68.6) | <0.001 |
NT-proBNP (pg/mL) *# | 178.4 (82.6, 458.7) | 435.2 (165.5, 1426.0) | <0.001 |
hsCRP (mg/L) *# | 2.7 (1.3, 6.0) | 6.2 (2.4, 17.9) | <0.001 |
hsTnI (ng/L) | 5.8 (3.3, 12.6) | 142.8 (10.4, 2754.2) | <0.001 |
Variable | hsTnI | hsCRP | NT-proBNP |
---|---|---|---|
Age | 0.10 (p < 0.001) | 0.08 (p < 0.001) | 0.29 (p < 0.001) |
Male | 0.04 (p = 0.072) | −0.11 (p < 0.001) | −0.13 (p < 0.001) |
BMI | 0.00 (p = 0.850) | 0.10 (p < 0.001) | −0.05 (p = 0230) |
Diabetes | 0.05 (p = 0.020) | 0.05 (p = 0.021) | 0.08 (p < 0.001) |
Smoker | 0.13 (p < 0.001) | 0.13 (p < 0.001) | 0.01 (p = 0.810) |
Dyslipidaemia | −0.10 (p < 0.001) | −0.08 (p < 0.001) | −0.06 (p = 0.084) |
Hypertension | −0.10 (p < 0.001) | −0.04 (p = 0.055) | 0.00 (p = 0.940) |
NT-proBNP | 0.60 (p < 0.001) | 0.39 (p < 0.001) | 1 |
CRP | 0.44 (p < 0.001) | 1 | 0.39 (p < 0.001) |
hsTnI | 1 | 0.44 (p < 0.001) | 0.6 (p < 0.001) |
Model | HR (95% CI) | p-Value | N | N Events | |
---|---|---|---|---|---|
hsTnI | 1 | 1.37 (1.23, 1.53) | <0.001 | 2193 | 231 |
2 | 1.39 (1.24, 1.57) | <0.001 | 2193 | 231 | |
3 | 1.06 (0.90, 1.26) | 0.470 | 2193 | 231 | |
hsCRP | 1 | 1.41 (1.24, 1.60) | <0.001 | 2193 | 231 |
2 | 1.41 (1.24, 1.60) | <0.001 | 2193 | 231 | |
3 | 1.16 (0.99, 1.35) | 0.064 | 2193 | 231 | |
NT-proBNP | 1 | 1.65 (1.40, 1.93) | <0.001 | 2193 | 231 |
2 | 1.64 (1.39, 1.92) | <0.001 | 2193 | 231 | |
3 | 1.47 (1.19, 1.82) | <0.001 | 2193 | 231 |
Model | HR (95% CI) | p-Value | N | N Events | |
---|---|---|---|---|---|
hsTnI | 1 | 1.39 (1.19, 1.61) | <0.001 | 2193 | 123 |
2 | 1.43 (1.22, 1.67) | <0.001 | 2193 | 123 | |
3 | 0.81 (0.65, 1.02) | 0.077 | 2193 | 123 | |
hsCRP | 1 | 1.60 (1.35, 1.89) | <0.001 | 2193 | 123 |
2 | 1.63 (1.38, 1.94) | <0.001 | 2193 | 123 | |
3 | 1.26 (1.02, 1.55) | 0.031 | 2193 | 123 | |
NT-proBNP | 1 | 2.37 (1.92, 2.91) | <0.001 | 2193 | 123 |
2 | 2.39 (1.93, 2.95) | <0.001 | 2193 | 123 | |
3 | 2.42 (1.86, 3.15) | <0.001 | 2193 | 123 |
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Nikorowitsch, J.; Ojeda, F.; Lackner, K.J.; Schnabel, R.B.; Blankenberg, S.; Zeller, T.; Karakas, M. Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease. Biomolecules 2020, 10, 394. https://doi.org/10.3390/biom10030394
Nikorowitsch J, Ojeda F, Lackner KJ, Schnabel RB, Blankenberg S, Zeller T, Karakas M. Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease. Biomolecules. 2020; 10(3):394. https://doi.org/10.3390/biom10030394
Chicago/Turabian StyleNikorowitsch, Julius, Francisco Ojeda, Karl J. Lackner, Renate B. Schnabel, Stefan Blankenberg, Tanja Zeller, and Mahir Karakas. 2020. "Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease" Biomolecules 10, no. 3: 394. https://doi.org/10.3390/biom10030394
APA StyleNikorowitsch, J., Ojeda, F., Lackner, K. J., Schnabel, R. B., Blankenberg, S., Zeller, T., & Karakas, M. (2020). Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, in Coronary Artery Disease. Biomolecules, 10(3), 394. https://doi.org/10.3390/biom10030394