Synthesis and Anticancer Activity of Dimeric Polyether Ionophores
Abstract
:1. Introduction
2. Materials and Methods
2.1. General Procedures
2.2. Synthesis
2.2.1. Synthesis of N-Propargyl Amide of Lasalocid Acid (Compound 4)
2.2.2. Synthesis of Propargyl Ester of Lasalocid Acid (Compound 5)
2.2.3. Synthesis of Propargyl Carbonate of Betulinic Acid (Compound 10)
2.2.4. General Procedure for Preparation of Triazole-Linked Dimers (Compounds 14–22)
2.2.5. General Procedure for Preparation of Dimeric Conjugates with Hydroxamic Acids (Compounds 23–24)
2.3. In Vitro Biological Studies
2.3.1. Cell Lines and Culture Conditions
2.3.2. Antiproliferative Activity Assay
3. Results
3.1. Precursor Design and Synthesis
3.2. Dimerization of Polyether Ionophores
3.3. Antiproliferative Activity
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Dedication
References
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Sulik, M.; Maj, E.; Wietrzyk, J.; Huczyński, A.; Antoszczak, M. Synthesis and Anticancer Activity of Dimeric Polyether Ionophores. Biomolecules 2020, 10, 1039. https://doi.org/10.3390/biom10071039
Sulik M, Maj E, Wietrzyk J, Huczyński A, Antoszczak M. Synthesis and Anticancer Activity of Dimeric Polyether Ionophores. Biomolecules. 2020; 10(7):1039. https://doi.org/10.3390/biom10071039
Chicago/Turabian StyleSulik, Michał, Ewa Maj, Joanna Wietrzyk, Adam Huczyński, and Michał Antoszczak. 2020. "Synthesis and Anticancer Activity of Dimeric Polyether Ionophores" Biomolecules 10, no. 7: 1039. https://doi.org/10.3390/biom10071039
APA StyleSulik, M., Maj, E., Wietrzyk, J., Huczyński, A., & Antoszczak, M. (2020). Synthesis and Anticancer Activity of Dimeric Polyether Ionophores. Biomolecules, 10(7), 1039. https://doi.org/10.3390/biom10071039