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Biomolecules
Volume 11
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10.3390/biom11101398
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Review

Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment

by
Yanyu Huang
1,
Hsiao-Chi Wang
2,
Junwei Zhao
1,
Ming-Heng Wu
3 and
Tsung-Chieh Shih
1,*
1
Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA
2
Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA
3
Graduate Institute of Translational Medicine and International Ph.D. Program for Translational Medicine, College of Medical Sciences and Technology, Taipei Medical University, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
Biomolecules 2021, 11(10), 1398; https://doi.org/10.3390/biom11101398
Submission received: 30 July 2021 / Revised: 18 September 2021 / Accepted: 19 September 2021 / Published: 23 September 2021
(This article belongs to the Special Issue Galectins: Their Network and Roles in Infection/Immunity/Tumor Growth Control 2021)
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Abstract

Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.
Keywords: Galectin-1; immunotherapy; microenvironment; LLS30 Galectin-1; immunotherapy; microenvironment; LLS30

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MDPI and ACS Style

Huang, Y.; Wang, H.-C.; Zhao, J.; Wu, M.-H.; Shih, T.-C. Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment. Biomolecules 2021, 11, 1398. https://doi.org/10.3390/biom11101398

AMA Style

Huang Y, Wang H-C, Zhao J, Wu M-H, Shih T-C. Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment. Biomolecules. 2021; 11(10):1398. https://doi.org/10.3390/biom11101398

Chicago/Turabian Style

Huang, Yanyu, Hsiao-Chi Wang, Junwei Zhao, Ming-Heng Wu, and Tsung-Chieh Shih. 2021. "Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment" Biomolecules 11, no. 10: 1398. https://doi.org/10.3390/biom11101398

APA Style

Huang, Y., Wang, H.-C., Zhao, J., Wu, M.-H., & Shih, T.-C. (2021). Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment. Biomolecules, 11(10), 1398. https://doi.org/10.3390/biom11101398

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