The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue

Wang, Qun; Sun, Jiayi; Liu, Mengyu; Zhou, Yaqi; Zhang, Lei; Li, Yanzhang

doi:10.3390/biom11121757

Open AccessReview

The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue

by

Qun Wang

^1,†,

Jiayi Sun

^2,†,

Mengyu Liu

²,

Yaqi Zhou

¹,

Lei Zhang

^1,*

and

Yanzhang Li

^1,*

¹

School of Basic Medical Sciences, Henan University, Kaifeng 475004, China

²

School of Clinical Medicine, Henan University, Kaifeng 475004, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Biomolecules 2021, 11(12), 1757; https://doi.org/10.3390/biom11121757

Submission received: 20 October 2021 / Revised: 21 November 2021 / Accepted: 23 November 2021 / Published: 24 November 2021

(This article belongs to the Topic Compounds with Medicinal Value)

Download

Browse Figures

Review Reports Versions Notes

Abstract

Obesity is characterized by excessive accumulation of fat in the body, which is triggered by a body energy intake larger than body energy consumption. Due to complications such as cardiovascular diseases, type 2 diabetes (T2DM), obstructive pneumonia and arthritis, as well as high mortality, morbidity and economic cost, obesity has become a major health problem. The global prevalence of obesity, and its comorbidities is escalating at alarming rates, demanding the development of additional classes of therapeutics to reduce the burden of disease further. As a central energy sensor, the AMP-activated protein kinase (AMPK) has recently been elucidated to play a paramount role in fat synthesis and catabolism, especially in regulating the energy expenditure of brown/beige adipose tissue and the browning of white adipose tissue (WAT). This review discussed the role of AMPK in fat metabolism in adipose tissue, emphasizing its role in the energy expenditure of brown/beige adipose tissue and browning of WAT. A deeper understanding of the role of AMPK in regulating fat metabolism and energy expenditure can provide new insights into obesity research and treatment.

Keywords: obesity; AMPK; brown/beige adipose tissue; energy expenditure; browning

Share and Cite

MDPI and ACS Style

Wang, Q.; Sun, J.; Liu, M.; Zhou, Y.; Zhang, L.; Li, Y. The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue. Biomolecules 2021, 11, 1757. https://doi.org/10.3390/biom11121757

AMA Style

Wang Q, Sun J, Liu M, Zhou Y, Zhang L, Li Y. The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue. Biomolecules. 2021; 11(12):1757. https://doi.org/10.3390/biom11121757

Chicago/Turabian Style

Wang, Qun, Jiayi Sun, Mengyu Liu, Yaqi Zhou, Lei Zhang, and Yanzhang Li. 2021. "The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue" Biomolecules 11, no. 12: 1757. https://doi.org/10.3390/biom11121757

APA Style

Wang, Q., Sun, J., Liu, M., Zhou, Y., Zhang, L., & Li, Y. (2021). The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue. Biomolecules, 11(12), 1757. https://doi.org/10.3390/biom11121757

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

The New Role of AMP-Activated Protein Kinase in Regulating Fat Metabolism and Energy Expenditure in Adipose Tissue

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI