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Biomolecules
Volume 11
Issue 2
10.3390/biom11020254
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Review

Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications

by
Alejandro Olivares-Hernández
1,2,
Luis Figuero-Pérez
1,2,
Juan Jesus Cruz-Hernandez
2,
Rogelio González Sarmiento
2,3,
Ricardo Usategui-Martin
4,5,6 and
José Pablo Miramontes-González
2,5,7,*
1
Department of Medical Oncology, University Hospital of Salamanca, 37007 Salamanca, Spain
2
Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain
3
Department of Medicine, University of Salamanca, 37007 Salamanca, Spain
4
IOBA, Universidad de Valladolid, 47011 Valladolid, Spain
5
Facultad de Medicina, Departamento de Medicina, Universidad de Valladolid, 45005 Valladolid, Spain
6
Red Temática de Investigación Cooperativa en Salud (RETICS), Oftared, Instituto de Salud Carlos III, 47011 Valladolid, Spain
7
Department of Internal Medicine, University Hospital Rio Hortega, 47012 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Biomolecules 2021, 11(2), 254; https://doi.org/10.3390/biom11020254
Submission received: 24 January 2021 / Revised: 5 February 2021 / Accepted: 6 February 2021 / Published: 10 February 2021
(This article belongs to the Special Issue Dopamine Receptor in Health and Diseases)
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Abstract

The dopaminergic system can adapt to the different physiological or pathological situations to which the kidneys are subjected throughout life, maintaining homeostasis of natriuresis, extracellular volume, and blood pressure levels. The role of renal dopamine receptor dysfunction is clearly established in the pathogenesis of essential hypertension. Its associations with other pathological states such as insulin resistance and redox balance have also been associated with dysfunction of the dopaminergic system. The different dopamine receptors (D1–D5) show a protective effect against hypertension and kidney disorders. It is essential to take into account the various interactions of the dopaminergic system with other elements, such as adrenergic receptors. The approach to therapeutic strategies for essential hypertension must go through the blocking of those elements that lead to renal vasoconstriction or the restoration of the normal functioning of dopamine receptors. D1-like receptors are fundamental in this role, and new therapeutic efforts should be directed to the restoration of their functioning in many patients. More studies will be needed to allow the development of drugs that can be targeted to renal dopamine receptors in the treatment of hypertension.
Keywords: dopamine; kidney; hypertension dopamine; kidney; hypertension

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MDPI and ACS Style

Olivares-Hernández, A.; Figuero-Pérez, L.; Cruz-Hernandez, J.J.; González Sarmiento, R.; Usategui-Martin, R.; Miramontes-González, J.P. Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications. Biomolecules 2021, 11, 254. https://doi.org/10.3390/biom11020254

AMA Style

Olivares-Hernández A, Figuero-Pérez L, Cruz-Hernandez JJ, González Sarmiento R, Usategui-Martin R, Miramontes-González JP. Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications. Biomolecules. 2021; 11(2):254. https://doi.org/10.3390/biom11020254

Chicago/Turabian Style

Olivares-Hernández, Alejandro, Luis Figuero-Pérez, Juan Jesus Cruz-Hernandez, Rogelio González Sarmiento, Ricardo Usategui-Martin, and José Pablo Miramontes-González. 2021. "Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications" Biomolecules 11, no. 2: 254. https://doi.org/10.3390/biom11020254

APA Style

Olivares-Hernández, A., Figuero-Pérez, L., Cruz-Hernandez, J. J., González Sarmiento, R., Usategui-Martin, R., & Miramontes-González, J. P. (2021). Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications. Biomolecules, 11(2), 254. https://doi.org/10.3390/biom11020254

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