Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes
Abstract
:1. Introduction
2. Epigenetics of Immune System and Its Role in the Development of Obesity- and T2D-Associated Inflammation
2.1. DNA Methylation
2.1.1. DNA Methylation and Regulation of Immunity
2.1.2. DNA Methylation and the Development of Inflammation in Obesity and T2D
2.2. Histone Modifications
2.2.1. Histone Modifications in Immunity
2.2.2. Histone Marks in Obesity and T2D
2.3. microRNAs
2.3.1. Role of microRNAs in the Immune Response
2.3.2. MicroRNAs and the Development of Inflammation in Metabolic Disorders
2.4. Adipocyte Hypertrophy: A Paradigm of Epigenetic Derangement in Chronic Inflammation
Study Model | Epigenetic Marks | Position | Processes | Medical Condition | Species | Ref |
---|---|---|---|---|---|---|
AT from Diet-induced Obesity model | DNA Hyper-methylation | Hoxa5 | Hox Gene Family, Adipogenesis, AT Macrophage Genes | Obesity, Impaired Glucose Metabolism, AT Inflammation | Mouse | [130] |
AT from Diet-induced Obesity model | - | Hoxa5 | ER Stress Signalling pathways, M2 Macrophage Polarization | Obesity, Impaired Glucose Metabolism, AT Inflammation | Mouse | [131] |
PMCs from Diet-induced Obesity Model | - | Zfp423 | Nf-κb Inflammatory pathway, ATM accumulation, LPS-induced Inflammation | Obesity, AT Inflammation | Mouse | [132] |
AT from Diet-induced Obesity and from Obese subjects | DNA Hyper-methylation | Ankrd26 | Adipocyte pro-inflammatory secretion, Il-8, Mcp-1, Rantes/Pro-inflammatory profile in AT | Obesity, Impaired Glucose Metabolism, Adiposity, AT Inflammation | Mouse | [133] |
3. Epigenetic Changes as Anti-Inflammatory Targets for Treatment of Metabolic Disorders
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Study Model | Epigenetic Marks | Position | Processes | Medical Condition | Species | Ref |
---|---|---|---|---|---|---|
SAT APC and PBL from FDR, PBL from Obese subjects | DNA Hypo-methylation | Global/PTPRD | Inflammation by chemokine and cytokine pathway and Adipogenesis/PTPs | SAT Hypertrophy, Familiarity for T2D, Obesity | Human | [117] |
SAT APC from FDR | DNA Hypo-methylation | ZMAT3 | Pro-Inflammatory markers: IL-6, MCP-1, RANTES, IL-8, MIP1b/Senescence and Aging | SAT Hypertrophy, Familiarity for T2D | Human | [121] |
SAT APC and PBL from FDR, PBL from Obese subjects | DNA Hyper-methylation | HOXA5 | WNT-Signaling Pathway, Adipogenesis | SAT Hypertrophy, Familiarity for T2D, Obesity | Human | [122] |
SAT APC from Human Hypertrophic Obesity | DNA Hyper-methylation | ZNF423 | Adipogenesis | SAT Hypertrophy | Human | [123] |
PBL from Obese Subjects | DNA Hyper-methylation | ANKRD26 | Adipocyte Pro-Inflammatory Markers: IL-1β, IL-6, IL-12, IL-8, IP-10, MIP-1α, MIP-1β, RANTES | Obesity, Cardio- metabolic Risk | Human | [124] |
SAT APC and PBL from FDR | Deregulation of miRNA expression | Mir-23a-5p, mir193a-5p, mir-193b-5p | Pro-inflammatory pathway, adipogenesis, IGF2 signaling | SAT Hypertrophy, Familiarity for T2D | Human | [125] |
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Zatterale, F.; Raciti, G.A.; Prevenzano, I.; Leone, A.; Campitelli, M.; De Rosa, V.; Beguinot, F.; Parrillo, L. Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes. Biomolecules 2022, 12, 982. https://doi.org/10.3390/biom12070982
Zatterale F, Raciti GA, Prevenzano I, Leone A, Campitelli M, De Rosa V, Beguinot F, Parrillo L. Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes. Biomolecules. 2022; 12(7):982. https://doi.org/10.3390/biom12070982
Chicago/Turabian StyleZatterale, Federica, Gregory Alexander Raciti, Immacolata Prevenzano, Alessia Leone, Michele Campitelli, Veronica De Rosa, Francesco Beguinot, and Luca Parrillo. 2022. "Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes" Biomolecules 12, no. 7: 982. https://doi.org/10.3390/biom12070982
APA StyleZatterale, F., Raciti, G. A., Prevenzano, I., Leone, A., Campitelli, M., De Rosa, V., Beguinot, F., & Parrillo, L. (2022). Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes. Biomolecules, 12(7), 982. https://doi.org/10.3390/biom12070982